Vitamin D May Be Beneficial in Asthma
Vitamin D may reduce the risk for sever asthma exacerbations and health care use.
HealthDay News -- For patients with asthma, vitamin D appears to reduce the risk of severe asthma exacerbations and health care use, according to a review published online September 5, 2016, in the Cochrane Database of Systematic Reviews. The research was published to coincide with the annual European Respiratory Society International Congress in London.
Adrian R. Martineau, MBBS, PhD, from the Queen Mary University, London, United Kingdom, and colleagues examined the efficacy of administration of vitamin D and its hydroxylated metabolites in reducing the risk of severe asthma exacerbations and improving symptom control. Data were included for 7 trials involving 435 children and 2 trials involving 658 adults.
The researchers found that vitamin D administration reduced the rate of exacerbations requiring systemic corticosteroids (rate ratio, 0.63; 3 studies) and the risk of having 1 or more exacerbations necessitating an emergency department visit, hospitalization, or both (odds ratio, 0.39; 7 studies). Vitamin D had no effect on the percentage predicted forced expiratory volume in 1 second or Asthma Control Test scores. Vitamin D administration also had no effect on the risk of serious adverse events.
"Meta-analysis of a modest number of trials in people with predominantly mild to moderate asthma suggests that vitamin D is likely to reduce both the risk of severe asthma exacerbation and health care use," the researchers wrote. "It is as yet unclear whether these effects are confined to people with lower baseline vitamin D status; further research, including individual patient data meta-analysis of existing datasets, is needed to clarify this issue."