General Endocrinology

Reduced Mortality for Women Undergoing Assisted Reproduction Likely Due to "Healthy Patient Effect"

Reduced Mortality for Women Undergoing Assisted Reproduction Likely Due to "Healthy Patient Effect"

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Researchers sought to determine whether the reduced mortality seen in women receiving reproductive assistance occurred as a result of improved general health in this population.

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

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Serum intact parathyroid hormone levels may be an early marker to predict postthyroidectomy hypocalcemia.

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

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Investigators examined the effect of progestin-only contraceptive on cardiometabolic outcomes, including stroke, MI, hypertension, diabetes, and VTE.

Hypoparathyroidism Treatment Granted Orphan Drug Designation

Hypoparathyroidism Treatment Granted Orphan Drug Designation

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TransCon PTH is a long-acting prodrug of parathyroid hormone designed to restore PTH to physiologic levels, normalizing blood and urinary calcium levels, serum phosphate levels and bone turnover.

Worse Survival for <i>BRCA</i> Germline Mutation Carriers in Pancreatic CA

Worse Survival for BRCA Germline Mutation Carriers in Pancreatic CA

BRCA1/BRCA2 germline mutation carriers with pancreatic ductal adenocarcinoma have worse survival after resection.

Factors Associated With Decision Regret After Elective Oocyte Cryopreservation

Factors Associated With Decision Regret After Elective Oocyte Cryopreservation

Researchers identified factors associated with regret following elective oocyte cryopreservation among 201 women undergoing fertility preservation between 2012 and 2016.

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

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For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

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The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.

Long-Term Efficacy, Safety of Metreleptin for Generalized Lipodystrophy

Long-Term Efficacy, Safety of Metreleptin for Generalized Lipodystrophy

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Investigators examined the safety and efficacy of metreleptin in patients with congenital or acquired generalized lipodystrophy.

Low Glycemic Index/Glycemic Load Decreases IGF-1 Levels in Adults With Acne

Low Glycemic Index/Glycemic Load Decreases IGF-1 Levels in Adults With Acne

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Medical nutrition therapy may be a practical treatment option for patients with acne, based on the diet-induced endocrine effects on acne-promoting pathways described in this study.

Asthma Risk Increased for Premenopausal Women Using Oral Contraceptives

Asthma Risk Increased for Premenopausal Women Using Oral Contraceptives

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Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.

Certain Foods May Impact Timing of Menopause

Certain Foods May Impact Timing of Menopause

Researchers studied women aged 40 to 65 years participating in the UK Women's Cohort Study, who had experienced natural menopause and responded to a food frequency questionnaire.

Hormonal Antiandrogen Therapy for Acne May Help Reduce Antibiotic Use

Hormonal Antiandrogen Therapy for Acne May Help Reduce Antibiotic Use

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Recognizing the increased need for antibiotic stewardship, the researchers consider HAAT to be a useful alternative to systemic antibiotic therapy that is effective and well tolerated among women with inflammatory acne.

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

One-hour plasma glucose is a useful predictor of retinopathy risk, has a predictive value similar to that of 2-hour plasma glucose, and may be considered as an alternative glucose time point during an oral glucose tolerance test.

Hormonal Contraceptives May Adversely Affect Psychological Health in Adolescent Girls

Hormonal Contraceptives May Adversely Affect Psychological Health in Adolescent Girls

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This finding suggests an adverse effect of hormonal contraception on psychological health in adolescent girls.

Reproductive Goals Vary After Spontaneous Abortion

Reproductive Goals Vary After Spontaneous Abortion

Health care providers should offer family planning counseling to all women after spontaneous abortion, remaining responsive to individual patient needs.

DPP-4 Inhibitors Not Tied to Increased Risk for Acute Pancreatitis in Seniors

DPP-4 Inhibitors Not Tied to Increased Risk for Acute Pancreatitis in Seniors

Study provides evidence that DPP-4 inhibitors are not associated with an increased risk of acute pancreatitis in older adults overall. The positive association observed in patients with CVD could be due to chance or bias but merits further investigation.

FDA Puts New Restrictions on Permanent Birth Control Implant Essure

FDA Puts New Restrictions on Permanent Birth Control Implant Essure

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The new Essure labeling restricts the sale and distribution of the device to only health care providers and facilities that provide information to patients about the risks and benefits of this device.

Eylea Meets Endpoint in Non-Proliferative Diabetic Retinopathy Trial

Eylea Meets Endpoint in Non-Proliferative Diabetic Retinopathy Trial

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Results so far (at week 24) show more than half of patients who received Eylea experienced a 2-step or greater improvement from baseline on the DRSS vs. patients who received a sham injection (58% vs 6%; P<0.0001).

Common Plant-Derived Oils May Contain Endocrine-Disrupting Chemicals

Common Plant-Derived Oils May Contain Endocrine-Disrupting Chemicals

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To investigate the potential association between male gynecomastia and essential oils, study authors from the National Institute of Environmental Health Sciences analyzed 8 common components included in lavender and tea tree oils.

Red Meat Consumption Linked to Insulin Resistance and Steatohepatitis

Red Meat Consumption Linked to Insulin Resistance and Steatohepatitis

Researchers used a food frequency questionnaire and a detailed meat questionnaire to measure meat type and cooking method.

Oral Micronized Progesterone May Decrease Perimenopausal Vasomotor Symptoms

Oral Micronized Progesterone May Decrease Perimenopausal Vasomotor Symptoms

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Oral micronized progesterone may diminish hot flushes and night sweats in perimenopausal women, according to research presented at ENDO 2018.

Lipid Metabolism Imbalance and Pathophysiology of Bipolar Disease

Lipid Metabolism Imbalance and Pathophysiology of Bipolar Disease

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Abnormal ratios of omega-6 to omega-3 fatty acids were associated with the presence of bipolar disorder and the severity and duration of major depressive disorder.

Weight Regain More Likely With Perfluoroalkyl Substances

Weight Regain More Likely With Perfluoroalkyl Substances

Higher concentrations of perfluoroalkyl substances are associated with greater weight regain in a diet-induced weight-loss setting.

Sudden Sensorineural Hearing Loss Recovery Lower With Metabolic Syndrome

Sudden Sensorineural Hearing Loss Recovery Lower With Metabolic Syndrome

Patients with metabolic syndrome have a lower rate of recovery from sudden sensorineural hearing loss than those without.

Little Effect on Metabolic Risk Factors With Addition of SSRIs to Antipsychotics

Little Effect on Metabolic Risk Factors With Addition of SSRIs to Antipsychotics

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A combination of selective serotonin reuptake inhibitors and antipsychotics does not lead to further deterioration of metabolic variables; however, metabolic monitoring should be performed.

Metabolic Syndrome and Gout: What's the Link?

Metabolic Syndrome and Gout: What's the Link?

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Michael Pillinger, MD, professor of medicine at New York University School of Medicine, spoke with Rheumatology Advisor about his team's recent review of gout and metabolic syndrome.

New Recommendations for High Blood Pressure Management, Prevention

New Recommendations for High Blood Pressure Management, Prevention

New recommendations have been developed for the prevention, detection, evaluation, and management of high blood pressure.

Modern Contraceptive Use Increasing in Developing Nations

Modern Contraceptive Use Increasing in Developing Nations

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Researchers used the Family Planning Estimation Tool to evaluate the performance of 68 of the 69 countries involved in the Family Planning 2020 initiative.

Spinal Cord Stimulation Reduces Pain in Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain in Diabetic Polyneuropathy

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As many as one-quarter of individuals with diabetes will experience painful neuropathic symptoms for which treatment is limited.

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