General Endocrinology

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Metabolic Syndrome and Gout: What's the Link?

Metabolic Syndrome and Gout: What's the Link?

Michael Pillinger, MD, professor of medicine at New York University School of Medicine, spoke with Rheumatology Advisor about his team's recent review of gout and metabolic syndrome.

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Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Serum intact parathyroid hormone levels may be an early marker to predict postthyroidectomy hypocalcemia.

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

Investigators examined the effect of progestin-only contraceptive on cardiometabolic outcomes, including stroke, MI, hypertension, diabetes, and VTE.

Hypoparathyroidism Treatment Granted Orphan Drug Designation

Hypoparathyroidism Treatment Granted Orphan Drug Designation

TransCon PTH is a long-acting prodrug of parathyroid hormone designed to restore PTH to physiologic levels, normalizing blood and urinary calcium levels, serum phosphate levels and bone turnover.

Worse Survival for BRCA Germline Mutation Carriers in Pancreatic CA

Worse Survival for BRCA Germline Mutation Carriers in Pancreatic CA

BRCA1/BRCA2 germline mutation carriers with pancreatic ductal adenocarcinoma have worse survival after resection.

Factors Associated With Decision Regret After Elective Oocyte Cryopreservation

Factors Associated With Decision Regret After Elective Oocyte Cryopreservation

Researchers identified factors associated with regret following elective oocyte cryopreservation among 201 women undergoing fertility preservation between 2012 and 2016.

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.

Long-Term Efficacy, Safety of Metreleptin for Generalized Lipodystrophy

Long-Term Efficacy, Safety of Metreleptin for Generalized Lipodystrophy

Investigators examined the safety and efficacy of metreleptin in patients with congenital or acquired generalized lipodystrophy.

Low Glycemic Index/Glycemic Load Decreases IGF-1 Levels in Adults With Acne

Low Glycemic Index/Glycemic Load Decreases IGF-1 Levels in Adults With Acne

Medical nutrition therapy may be a practical treatment option for patients with acne, based on the diet-induced endocrine effects on acne-promoting pathways described in this study.

Asthma Risk Increased for Premenopausal Women Using Oral Contraceptives

Asthma Risk Increased for Premenopausal Women Using Oral Contraceptives

Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.

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