General Endocrinology Archive
From 2005 through 2014, an estimated 14,178 metabolic and bariatric surgery (MBS) procedures were performed among pediatric patients aged 20 years and younger with severe obesity.
High childhood body mass index is strongly correlated with slipped capital femoral epiphysis.
The Endocrine Society has expressed concern regarding the FDA's position on use of BPA in commercial products.
Guidelines have been updated to support the health care transition from adolescence to adulthood.
Researchers described signs and symptoms in the years prior to acromegaly diagnosis and reported on differences between men and women in their clinical manifestations.
Thyroid stimulating hormone levels at diagnosis and the L-thyroxine dose through treatment may distinguish between permanent and transient congenital hypothyroidism.
Diazoxide treatment in children with congenital hyperinsulinism is associated most commonly with neutropenia, but also carries a risk for pulmonary hypertension.
Breastfeeding is inversely associated with body mass index z scores measured at 12 months, and the association is attenuated with formula supplementation by six months.
Primary cancer rates and mortality risk were no higher for pediatric patients treated with growth hormone therapy.
The Company is investigating the treatment as a combination with nab-paclitaxel (Abraxane; Celgene) for pancreatic cancers and other solid tumors.
One-third of the women enrolled in Michigan's Medicaid expansion program reported improved access to birth control and family planning services.
There is a reduction in ovarian cancer risk associated with use of contemporary combined hormonal contraceptives.
Following an educational intervention, residents from pediatrics and med-ped residency programs have an increase in total emotional intelligence.
The upper level of vitamin D recommended by the Endocrine Society can result in frequent hypercalciuria.
The guideline highlights shared decision making among patients, their families, and physicians for the management of congenital adrenal hyperplasia.
To understand the associations between exposure to gestational diabetes and the risk for maternal glucose metabolism and childhood adiposity, researchers followed a cohort of mothers and children for a median of 11.4 years.
Total thyroxine in newborns was measured by heel-stick blood spot test.
The AAP recommends that youth who identify as TGD have access to comprehensive, gender affirming, and developmentally appropriate health care.
Altered serum levels of nicotinamide phosphoribosyltransferase, omentin-1, and caspase-cleaved cytokeratin 18 fragment M30 in children with type 1 diabetes may signify metabolic differences that do not stabilize with insulin treatment.
First-phase and glucose-potentiation of arginine-induced insulin secretion as assessed by acute C-peptide responses improved after the initiation of ivacaftor in children with cystic fibrosis.
Investigators examined the reliability of the clonidine test in children with short stature who had been evaluated for suspected growth hormone deficiency.
Individuals with higher executive function performance at baseline experienced slower increases in HbA1c.
From 2013 to 2016 there was an increase in children's participation in Medicaid and the Children's Health Insurance Program.
Increases in use of one or more contraceptive methods, dual-method use, long-acting reversibles.
The risk for meningioma was not significantly higher in patients who did not receive radiotherapy.
1 in 3 women of reproductive age report better ability to access birth control, family planning services.
Investigators sought to determine the effect of birth weight, weight gain from 0 to 2 years, and adiposity on insulin resistance and sensitivity in early adolescence.
The prenatal sex steroid theory hypothesizes that women with PCOS would have heightened autistic traits and an increased rate of autism among their children.
Investigators sought to improve growth-monitoring programs by examining existing algorithms and examined the effect of using WHO vs national growth charts on algorithm performance.
New-onset adult diabetes mellitus appears to be both a risk factor for and a sequelae of pancreatic cancer.
Sleep apnea is common in patients with acromegaly and is often diagnosed before the diagnosis of acromegaly.
Experts in the management of acromegaly provide new recommendations on the medical management of acromegaly since the last published update in 2014.
Monthly pasireotide injections may benefit patients with acromegaly who are resistant to first-generation somatostatin analogs.
Serum 25-hydroxyvitamin D [25(OH)D] is independently and inversely associated with total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol in children.
Investigators observed an increased rate of obsessive compulsive disorder and somatization in women with polycystic ovary syndrome.
Counseling about impaired fertility and sexual function for at-risk pediatric populations in developmentally appropriate ways is essential.
The American Society for Metabolic and Bariatric Surgery Pediatric Committee has updated their 2012 evidence-based guidelines.
The algorithm was designed to account for sperm survival, variation in cycle length, ovulation day, temperature fluctuations and the length of the follicular and luteal phases of the menstrual cycle.
Although patients reach clinical and biochemical remission, patients exposed to hypercortisolism do not show functional remission.
The safety and efficacy of Annovera was evaluated in 3 open-label clinical trials involving healthy women (ages 18 to 40).
The lifestyle physical activity program included weight education, control, self-monitoring, behavioral change techniques, and maintenance of behavior change.
There are 14 states that perform a routine second screening in infants at approximately 2 weeks of age.
It is critical for us to remember that children are not little adults. Pediatric-onset diabetes is different from adult-onset diabetes due to its distinct epidemiology, pathophysiology, developmental considerations, and response to therapy.
In patients with hypotonic polyuria, the direct measurement of hypertonic saline-stimulated plasma copeptin has better diagnostic accuracy than the water-deprivation test.
The treatment goals for Cushing syndrome are to normalize cortisol levels, reverse clinical symptoms, and if possible to remove the secreting neoplasm.
International evidence-based guidelines include 166 recommendations and practice points to improve health outcomes of women with PCOS.
Investigators examine the association between various skin conditions and metabolic syndrome.
Investigators assessed the association of hepatitis B infection and pancreatic cancer, along with predictors of pancreatic cancer and mortality.
Men with migraines were found to have increased levels of estradiol and to be more likely to have relative androgen deficiency compared with men without migraines.
Adolescent and young adult cancer survivors have a 73 percent higher risk of endocrine diseases.
The association between preconception Vitamin D levels and pregnancy outcomes in women with previous pregnancy losses was examined.
Investigators aimed to assess biochemical predictors of renal calcifications in patients with primary hyperparathyroidism.
The utility of IGF-I and IGFBP-3 for growth hormone testing in childhood cancer survivors was examined.
Investigators examine the onset of puberty and testicular function in prepubertal boys treated with oxandrolone.
The current study sought to compare the incidence of acute cardiovascular events among transgender persons.
Serum prolactin level 6 to 12 months after dopamine agonist withdrawal may be a useful predictor for clinical outcomes in patients with prolactinoma.
Investigators examined whether primary conservative monitoring is a safe strategy in patients with non-functioning pituitary adenomas.
These data suggest that aripiprazole can be safely used in premenopausal women to treat elevated prolactin levels and prolactin-related adverse effects.
Data from a prospective cohort study were used to determine the effect of estradiol levels on all-cause and cause-specific mortality in men aged ≥65 years.
For this study, the authors aimed to quantify this effect by conducting a systematic review of various databases to identify studies that included a placebo arm and used Female Sexual Function Index as a clinical outcome.
ISPAD recommends adjustments for fluid management regarding rehydration rates in children and adolescents with diabetes ketoacidosis.
Investigators revised pooled cohort equations to improve clinical accuracy to predict risk for cardiovascular disease.
Half of meds ID'd in expanded access programs treat cancer; others for metabolic, endocrine diseases
Investigators examined the frequency of comorbidity screening and the frequency of comorbidities in patients with acromegaly.
Researchers examined unplanned pregnancies and contraceptive use among HIV-positive women in a cross-sectional study.
The MiniMed 670G system measures glucose levels every 5 minutes and automatically adjusts insulin delivery to avoid highs and lows.
In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.
Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.
Researchers assessed the effect of formula supplementation vs breastfeeding on the gut microbiome and risk of infant overweight.
Researchers sought to determine whether the reduced mortality seen in women receiving reproductive assistance occurred as a result of improved general health in this population.
Serum intact parathyroid hormone levels may be an early marker to predict postthyroidectomy hypocalcemia.
Investigators examined the effect of progestin-only contraceptive on cardiometabolic outcomes, including stroke, MI, hypertension, diabetes, and VTE.
TransCon PTH is a long-acting prodrug of parathyroid hormone designed to restore PTH to physiologic levels, normalizing blood and urinary calcium levels, serum phosphate levels and bone turnover.
BRCA1/BRCA2 germline mutation carriers with pancreatic ductal adenocarcinoma have worse survival after resection.
Researchers identified factors associated with regret following elective oocyte cryopreservation among 201 women undergoing fertility preservation between 2012 and 2016.
For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.
The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.
Investigators examined the safety and efficacy of metreleptin in patients with congenital or acquired generalized lipodystrophy.
Subcutaneous burosumab decreases mean Thacher rickets severity total score from dosing every two weeks or every four weeks.
Medical nutrition therapy may be a practical treatment option for patients with acne, based on the diet-induced endocrine effects on acne-promoting pathways described in this study.
These findings can inform clinical practice in that type 2 diabetes should be considered in ADHD even in the absence of other known risk factors.
Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.
Investigators examined changes in weight from childhood to early adulthood and the risk for developing type 2 diabetes.
Investigators examined glycemic control variations in 8 high-income countries from multicenter registries in children with type 1 diabetes.
Researchers studied women aged 40 to 65 years participating in the UK Women's Cohort Study, who had experienced natural menopause and responded to a food frequency questionnaire.
Maternal caffeine intake >200 mg/day during pregnancy was associated with high weight gain velocity beginning from the first months of life and higher BMI throughout childhood.
For children and adults with type 1 diabetes, consuming a very low-carbohydrate diet is associated with exceptional glycemic control.
Recognizing the increased need for antibiotic stewardship, the researchers consider HAAT to be a useful alternative to systemic antibiotic therapy that is effective and well tolerated among women with inflammatory acne.
Routine screening for neonatal hypoglycemia after pregnancies complicated by gestational diabetes (GD) reveals high incidence of both mild and severe hypoglycemia for both diet-controlled and insulin-treated GD and across the full range of birth weight centiles.
The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.
Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D
The study highlights mitochondrial and autophagic differences in the muscles of young adults with type 1 diabetes with moderate glycemic control who exceed recommended activity levels.
Study is the first to reveal a higher prevalence of iodine deficiency and hypothyroidism in children receiving chronic parenteral nutrition.
Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.
Further clinical trials are needed to explore the potential beneficial effect of vitamin D supplementation, via fortified foods and/or dietary supplements, on insulin resistance, and possibly on weight management.
Ethnicity,race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver.
One-hour plasma glucose is a useful predictor of retinopathy risk, has a predictive value similar to that of 2-hour plasma glucose, and may be considered as an alternative glucose time point during an oral glucose tolerance test.
Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle.
Awareness of ASD and its manifestations and comorbidities remain imperative in the treatment of T1D, as both conditions require long-term medical follow-up to continue improving diabetes care and metabolic control outcomes.
This finding suggests an adverse effect of hormonal contraception on psychological health in adolescent girls.
Researchers examined the relationship between early to mid-childhood adiposity measures and mid-childhood alanine aminotransferase levels.
Endocrinology Advisor Articles
- Testosterone Use Remains High Among Men With Coronary Artery Disease
- Insulin Analogs vs Regular Human Insulin for Type 2 Diabetes
- Primary Characteristics of PCOS Predictive of Obstetric Complications
- Trends in Bisphosphonate Use and Hip Fracture Rates in Denmark
- Maternal Thyroid Function in Pregnancy Linked to Childhood Risk for Disease
- ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care
- Sleep Habits Affect Insulin Sensitivity in Adolescents With Overweight, Obesity
- Levothyroxine Associated With Increased Mortality in Patients With Heart Failure
- Head-to-Head Comparison of Professional vs Personal CGM Systems in T1D
- Dual vs Triple Therapy for Metformin Treatment Intensification in Type 2 Diabetes
- Risk for Congenital Heart Defects in Offspring of Mothers With Obesity
- Is the MiniMed 670G System Safe for Children With Type 1 Diabetes?
- Gender-Affirming Hormonal Treatment and Long-Term Bone Safety
- Obesity Linked to Lower Gray Matter Brain Volume
- No Evidence for Health Benefits of Nonsugar Sweeteners