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FLAGYL ER
Vaginal infections
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Drug Name:

FLAGYL ER Rx

Generic Name and Formulations:
Metronidazole 750mg; ext rel tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for FLAGYL ER:

Bacterial vaginosis in non-pregnant women.

Adult:

Swallow whole. Take 1hr before or 2hrs after meals. 750mg once daily for 7 days. Severe hepatic impairment: not recommended. Hemodialysis: consider dose supplementation after session.

Children:

Premenarche: not established.

Contraindications:

Pregnancy (1st trimester for trichomoniasis). Within 2 weeks of disulfiram (possible psychotic reactions). Concomitant alcohol or propylene glycol containing-products during or at least 3 days after treatment.

Warnings/Precautions:

Discontinue if abnormal neurological symptoms occur. Candidiasis. History of blood dyscrasias. Monitor for leukopenia; do CBCs before, during and after therapy. Risk of severe/fatal hepatotoxicity in Cockayne Syndrome; obtain LFTs (at baseline, within first 2–3 days after initiation, frequently during therapy, and after completion); discontinue if elevated. Hepatic or renal impairment; monitor. Elderly: monitor serum levels. Pregnancy. Nursing mothers: not recommended.

See Also:

FLAGYL

FLAGYL 375

Pharmacological Class:

Antiprotozoal/antibacterial.

Interactions:

See Contraindications. May potentiate oral anticoagulants, lithium; monitor. Avoid concomitant busulfan; if needed, adjust busulfan dose and monitor. May be antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. May be potentiated by cimetidine, other hepatic enzyme inhibitors. IV: may potentiate 5-FU, vecuronium, CYP3A4 substrates (eg, amiodarone, tacrolimus, cyclosporine,carbamazepine, phenytoin, quinidine); monitor. May interfere with serum chemistry tests.

Adverse Reactions:

Nausea, headache, anorexia, vomiting, diarrhea, epigastric distress, abdominal cramping, constipation, metallic taste, dysuria, cystitis; seizures, encephalopathy, optic/peripheral neuropathy, aseptic meningitis.

How Supplied:

Tabs—50, 100; ER—30; Caps 375mg—50

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