Hyperacidity, GERD, and ulcers:

Indications for ZEGERID for ORAL SUSPENSION:

Short-term treatment of active benign gastric ulcer, active duodenal ulcer, erosive esophagitis (EE). Symptomatic GERD. Maintenance of healing of EE. To reduce risk of upper GI bleed in critically ill patients (40mg oral susp only).


Take on empty stomach. Caps: swallow whole with water only. Susp: mix in 15–30mL water only; drink immediately; refill cup with water and drink; or, may give via NG/OG tube (see full labeling). Due to sodium bicarbonate component, two 20mg packets or caps are not equivalent to one 40mg packet or cap. ≥18yrs: Active duodenal ulcer: 20mg once daily for 4 weeks; may continue 4 more weeks. Gastric ulcer: 40mg once daily for 4–8 weeks. GERD (no esophageal lesions): 20mg once daily for up to 4 weeks. EE with GERD symptoms: 20mg once daily for 4–8 weeks. Maintenance of healing of EE: 20mg once daily. GI bleed risk reduction: Day 1: initially 40mg susp once then 40mg susp 6–8hrs later, then 40mg susp once daily for up to 14 days. Hepatic impairment or Asian: consider reduced dose.


<18yrs: not established.


Symptomatic response does not preclude gastric malignancy. Discontinue if acute interstitial nephritis, cutaneous/systemic lupus erythematosus occurs. Bartter's syndrome. Sodium-restricted diets. Hypokalemia. Hypocalcemia. Acid-base abnormalities. Long-term therapy (eg, >3yrs) may lead to malabsorption/deficiency of Vit. B12. Monitor magnesium levels during prolonged therapy. Increased risk of fundic gland polyps with long-term use (esp. >1yr) or osteoporosis-related fractures (hip, wrist or spine) with long-term (>1yr) and multiple daily dose PPI therapy. Use lowest dose for shortest duration appropriate to condition. Pregnancy (Cat.C). Nursing mothers: not recommended.

See Also:

Pharmacologic Class:

Proton pump inhibitor + antacid.


Avoid concomitant clopidogrel, St. John's Wort, rifampin. May potentiate diazepam, phenytoin, warfarin (monitor INR/PT), tacrolimus, saquinavir, clarithromycin, methotrexate (esp. high-dose). Potentiated by voriconazole, clarithromycin. May alter absorption of pH-dependent drugs (eg, ketoconazole, erlotinib, mycophenolate mofetil, ampicillin, iron, digoxin). May antagonize atazanavir, nelfinavir: not recommended. Monitor drugs metabolized by CYP450 (eg, cyclosporine, disulfiram, benzodiazepines). Long-term use with calcium or milk may cause milk-alkali syndrome. Concomitant digoxin, diuretics may predispose patients to hypomagnesemia. May interfere with neuroendocrine diagnostic tests.

Adverse Reactions:

Headache, abdominal pain, nausea, diarrhea, vomiting, flatulence; bone fracture; possible C. difficile associated diarrhea; rare: hypomagnesemia.


Hepatic. 95% protein bound.


Renal (major), fecal, biliary.

Generic Availability:

Caps (YES); susp (NO)

How Supplied:

Caps—30; Susp—30 packets/box