Miscellaneous urogenital disorders:
Indications for THIOLA:
In combination with high fluid intake, alkali and diet modification, to prevent cystine stone formation in patients with severe homozygous cystinuria who are not responsive to these measures alone.
Adult Dosage:
Give in 3 divided doses at least 1hr before or 2hrs after meals. EC tabs: swallow whole. Initially 800mg/day; usual dose 1000mg/day. Measure urinary cystine at 1 month after initiation, and every 3 months thereafter. Adjust dose to maintain urinary cystine levels <250mg/L. Severe toxicity to d-penicillamine: may start with lower dose.
Children Dosage:
<20kg: not established. ≥20kg: Give in 3 divided doses at least 1hr before or 2hrs after meals. EC tabs: swallow whole. Initially 15mg/kg/day. Avoid doses >50mg/kg per day (increased risk of proteinuria). Measure urinary cystine at 1 month after initiation, and every 3 months thereafter. Adjust dose to maintain urinary cystine levels <250mg/L. Severe toxicity to d-penicillamine: may start with lower dose.
THIOLA Warnings/Precautions:
Monitor urinary protein prior to initiation, then every 3 to 6 months during treatment; discontinue if proteinuria occurs. Monitor renal function. Elderly. Pregnancy. Nursing mothers: not recommended.
See Also:
THIOLA Classification:
Reducing agent.
THIOLA Interactions:
EC tabs: avoid alcohol 2hrs before and 3hrs after dose.
Adverse Reactions:
Nausea, diarrhea or soft stools, oral ulcers, rash, fatigue, fever, arthralgia, proteinuria, emesis; hypersensitivity reactions, hypogeusia.
Generic Drug Availability:
NO
How Supplied:
Tabs—100; EC tabs 100mg—300; 300mg—90
