• Constipation and bowel cleansers

Constipation and bowel cleansers:

Indications for PLENVU:

Bowel cleansing before colonoscopy.

Adult:

No solid food from start of prep. No clear liquids at least 2hrs before colonoscopy. Two-day regimen: start the evening before colonoscopy, drink 480mL over 30mins, follow with 480mL of clear liquids over next 30mins; in the AM, drink 480mL over 30mins, then drink 480mL of clear liquids over next 30mins. Consume additional water or clear liquids up to 2hrs before colonoscopy. One-day regimen: start the morning of colonoscopy, drink 480mL over 30mins, follow with 480mL of clear liquids over next 30mins. At minimum of 2hrs after first dose, drink 480mL over 30mins, follow with 480mL of clear liquids over next 30mins. Consume additional water or clear liquids up to 2hrs before colonoscopy.

Children:

Not established.

Contraindications:

GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic megacolon.

Warnings/Precautions:

Correct fluid/electrolyte abnormalities before use. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, cardiomyopathy, or electrolyte imbalance: increased risk of arrhythmias; consider pre-dose and post-colonoscopy ECGs. History or risk of seizures. Renal impairment; perform baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. G6PD deficiency. Phenylketonuria. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Osmotic laxative.

Interactions:

Caution with drugs that increase risk of fluid/electrolyte abnormalities, renal impairment, seizures, arrhythmias, or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Concomitant stimulant laxatives: not recommended; may increase risk of mucosal ulceration, ischemic colitis. Oral drugs administered within 1hr of start of Plenvu may not be absorbed.

Adverse Reactions:

Nausea, vomiting, dehydration, abdominal pain/discomfort, fatigue, headache; hypersensitivity reactions; rare: arrhythmias, tonic-clonic seizures.

Generic Availability:

NO

How Supplied:

Carton—1 (disposable container w. 3 pouches)