Viral infections:

Indications for PIFELTRO:

In combination with other antiretroviral agents for HIV-1 infection in antiretroviral treatment-naïve adult patients.

Adult:

≥18yrs: 100mg once daily. Concomitant rifabutin: 100mg twice daily (approx. 12hrs apart).

Children:

<18yrs: not established.

Contraindications:

Concomitant strong CYP3A inducers (eg, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, enzalutamide, rifampin, rifapentine, mitotane, St. John's wort): discontinue for ≥4wks prior to starting Pifeltro.

Warnings/Precautions:

Immune reconstitution syndrome. ESRD or dialysis: not studied. Severe hepatic impairment (Child-Pugh C): not studied. Elderly. Pregnancy. Nursing mothers: not recommended.

Pharmacologic Class:

Non-nucleoside reverse transcriptase inhibitor.

Interactions:

Concomitant efavirenz, etravirine, nevirapine: not recommended. May be antagonized by CYP3A inducers (see Contraindications). May be potentiated by CYP3A inhibitors.

Adverse Reactions:

Nausea, dizziness, headache, fatigue, diarrhea, abdominal pain, abnormal dreams.

Note:

To register pregnant patients to the Antiretroviral Pregnancy Registry, call (800) 258–4263.

Generic Availability:

NO

How Supplied:

Tabs—30

Pricing for PIFELTRO

100mg tablet (Qty: 30)
Appx. price $1375
GoodRx