Electrolyte disturbances:

Indications for PHOXILLUM:

Replacement solution for patients on continuous renal replacement therapy (CRRT), to replace plasma volume removed by ultrafiltration and correct electrolyte and acid-base imbalances. To remove dialyzable toxins associated with drug poisoning treated by CRRT.

Adults and Children:

Administer only under the direction of a physician trained in intensive care treatment including CRRT: see full labeling. Individualize; determine mode of therapy, solute formulation, flow rates, and duration based on patient’s clinical condition and electrolyte, acid-base, and glucose balances. Administer into extracorporeal circuit before (pre-dilution) and/or after (post-dilution) the hemofilter or hemodiafilter.

Warnings/Precautions:

Use aseptic technique. Monitor fluid, hemodynamic, electrolyte, and acid-base imbalances; correct as needed. Increased risk of metabolic acidosis. Monitor blood glucose levels; initiate or modify antidiabetic therapy as needed. Pregnancy, nursing mothers: monitor.

Pharmacologic Class:

Fluid & electrolyte replacement.

Interactions:

May antagonize dialyzable drugs: monitor. Concomitant citrate (as anticoagulant) may reduce plasma calcium; select appropriate Phoxillum formulation. May add drugs to bag via injection connector; administer non-phosphate drugs through different access line.

Adverse Reactions:

Metabolic acidosis, hypotension, acid-base disorders, electrolyte and fluid imbalance.

Generic Availability:

NO

How Supplied:

2-compartment bag (5000mL)—1