Hyperacidity, GERD, and ulcers:

Indications for PEPCID:

Active duodenal ulcer. Maintenance of healed duodenal ulcer. Active benign gastric ulcer. Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome, multiple endocrine adenomas). Gastroesophageal reflux disease (GERD). Esophagitis due to GERD.

Adult:

Duodenal ulcer: 40mg once daily at bedtime or 20mg twice daily for 4–8 weeks. Maintenance: 20mg once daily at bedtime. Benign gastric ulcer: 40mg once daily at bedtime for up to 8 weeks. Hypersecretory conditions: Initially 20mg every 6hrs; individualize. GERD symptoms: 20mg twice daily for up to 6 weeks. Esophagitis: 20–40mg twice daily for up to 12 wks (see full labeling).

Children:

Individualize; adjust based on response. <1yr: not recommended. 1–16yrs: Peptic ulcer: Initially 0.5mg/kg per day at bedtime or in 2 divided doses; max 40mg/day. GERD: Initially 1mg/kg per day divided in 2 doses; max 40mg twice daily.

Contraindications:

History of serious hypersensitivity reactions to H2 receptor antagonists.

Warnings/Precautions:

Symptomatic response does not preclude gastric malignancy; evaluate prior to initiation. Moderate to severe renal impairment (CrCl <50mL/min): reduce to ½ the dose or prolong dosing interval to 36–48hrs. Elderly: use low doses. Pregnancy. Nursing mothers.

Pharmacologic Class:

H2 blocker.

Interactions:

Concomitant dasatinib, delavirdine mesylate, cefditoren, fosamprenavir: not recommended. May alter absorption of pH-dependent drugs (eg, atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, rilpivirine). May potentiate CYP1A2 substrates (eg, tizanidine); avoid; if necessary, monitor for hypotension, bradycardia, drowsiness. May give antacids concomitantly.

Adverse Reactions:

Headache, dizziness, constipation, diarrhea, inj site reactions; rare: CNS reactions, prolonged QT interval in renal impairment (moderate and severe).

Note:

Formerly known under the brand name Pepcid Injection.

How Supplied:

Tabs—30, 100; Susp—50mL; Inj—contact supplier

Pricing for PEPCID

20mg tablet (Qty: 60)
Appx. price $11
GoodRx