Indications for Oxybutynin Chloride:
Symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (eg, urinary urgency, frequency, leakage, urge incontinence, dysuria).
5mg 2–3 times a day; max 20mg/day.
<5yrs: not recommended. ≥5yrs: 5mg twice daily; max 15mg/day.
Oxybutynin Chloride Contraindications:
Uncontrolled glaucoma. GI obstruction. Paralytic ileus. Intestinal atony in elderly or debilitated. Severe colitis. Myasthenia gravis. Megacolon. Toxic megacolon in ulcerative colitis. Obstructive uropathies. Unstable cardiovascular status in acute hemorrhage.
Oxybutynin Chloride Warnings/Precautions:
Activities requiring mental alertness. Diarrhea. Hepatic or renal disease. Autonomic neuropathy. Hyperthyroidism. Cardiovascular disease. Hiatal hernia. GI or GU obstruction. Ulcerative colitis. Exposure to extreme heat. Elderly. Pregnancy (Cat.B). Nursing mothers.
Oxybutynin Chloride Classification:
Oxybutynin Chloride Interactions:
Potentiates drowsiness with alcohol, other CNS depressants. Additive anticholinergic effects with other anticholinergics. May be potentiated by CYP3A4 inhibitors. Decreases GI motility, possibly affecting absorption of other drugs.
Dry mouth, constipation, somnolence, headache, diarrhea, nausea, tachycardia, blurred vision, dry eyes, other anticholinergic effects.
Formerly known under the brand name Ditropan.