• Hyperlipoproteinemias

Hyperlipoproteinemias:

Indications for FENOGLIDE:

Adjunct to diet in severe hypertriglyceridemia and to reduce elevated LDL-C, total-C, TG, and apo B, and to increase HDL-C, in primary hyperlipidemia or mixed dyslipidemia.

Limitations of Use:

Not shown to reduce coronary heart disease morbidity and mortality in patients with type 2 diabetes.

Adult:

Take with food. Hypertriglyceridemia: 40–120mg/day; adjust at 4–8 week intervals; max 120mg/day. Hyperlipidemia, dyslipidemia: initially 120mg/day. Mild to moderately renal impairment: initially 40mg/day.

Children:

Not established.

Contraindications:

Severe renal impairment (including dialysis). Active liver disease. Unexplained persistent liver function abnormalities. Primary biliary cirrhosis. Gallbladder disease. Nursing mothers (during and for 5 days after last dose).

Warnings/Precautions:

Mild to moderate renal impairment; monitor. Monitor CBCs and liver function; discontinue if ALT (SGPT) levels >3xULN persist. Discontinue if markedly elevated CPK levels, myopathy, gallstones, hypersensitivity reactions, or paradoxical decreases in HDL occur. Elderly. Pregnancy.

Pharmacologic Class:

Fibrate.

Interactions:

Avoid statins. Potentiates oral anticoagulants (monitor). Allow at least 1 hour before or 4–6 hours after bile acid sequestrants. Caution with colchicine, immunosuppressants (eg, cyclosporine), other nephrotoxic drugs.

Adverse Reactions:

Abnormal liver function tests, increased AST, ALT, CPK, rhinitis; respiratory or GI effects, myopathy, cholelithiasis, pancreatitis, increased serum creatinine, rash, hypersensitivity reactions (may be severe); rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias.

Generic Availability:

YES

How Supplied:

Tabs—90

Pricing for FENOGLIDE

120mg tablet (Qty: 30)
Appx. price $290
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