Indications for Famciclovir:
In immunocompetent adults: treatment of recurrent herpes labialis, treatment of recurrent episodes of genital herpes, chronic suppressive therapy of recurrent episodes of genital herpes, treatment of herpes zoster. In HIV-infected adults: treatment of recurrent episodes of orolabial or genital herpes. Limitations of use: not established for patients with 1st episode of genital herpes or ophthalmic zoster, immunocompromised patients other than for treatment of recurrent orolabial or genital herpes in HIV-infected patients, Black and African American patients with recurrent genital herpes.
≥18yrs: Herpes zoster: start as soon as herpes zoster is diagnosed (within 72hrs of onset of rash); treat for 7 days; 500mg every 8hrs. CrCl 40–59mL/min: 500mg every 12hrs; CrCl 20–39mL/min: 500mg every 24hrs; CrCl <20mL/min: 250mg every 24hrs; hemodialysis (HD): 250mg after each dialysis. Treatment of recurrent genital herpes: begin therapy at first sign or symptom (within 6hrs); 1000mg every 12hrs for 1 day; CrCl 40–59mL/min: 500mg every 12hrs for 1 day; CrCl 20–39mL/min: 500mg single dose; CrCl <20mL/min: 250mg single dose; HD: 250mg after dialysis. Suppression of recurrent genital herpes: 250mg every 12hrs (for up to 1yr). CrCl 20–39mL/min: 125mg every 12hrs; CrCl <20mL/min: 125mg every 24hrs; HD: 125mg after each dialysis. Recurrent herpes labialis: start at first sign or symptom of cold sore: treat with single dose: 1500mg. CrCl 40–59mL/min: 750mg; CrCl 20–39mL/min: 500mg; CrCl <20mL/min: 250mg; HD: 250mg following dialysis. Orolabial or genital herpes simplex in HIV patients: treat for 7 days: 500mg every 12hrs; CrCl 20–39mL/min: 500mg every 24hrs; CrCl <20mL/min: 250mg every 24hrs; HD: 250mg after each dialysis.
<18yrs: not established.
Allergic to penciclovir cream.
Renal dysfunction. Pregnancy. Nursing mothers.
Probenecid, others eliminated by active tubular secretion may increase penciclovir concentrations. May be affected by drugs metabolized by aldehyde oxidase.
Headache, nausea, fatigue, paresthesia, pruritus.
Formerly known under the brand name Famvir.