Indications for: ENTEREG
To accelerate the time to upper and lower gastrointestinal recovery following surgeries that include partial bowel resection surgery with primary anastomosis.
Give 12mg 30mins to 5hrs before surgery, then 12mg twice daily starting on 1st post-op day until hospital discharge for up to 7 days; max 15 doses.
Opioid use, at therapeutic doses, for >7 consecutive days prior.
Potential risk of MI with long-term use: for short-term hospital use only.
For short-term hospital use only. Potential risk of MI with long-term use. Severe hepatic impairment, ESRD, complete GI obstruction, pancreatic or gastric anastomosis: not recommended. Mild to severe renal impairment or mild to moderate hepatic impairment: monitor closely; discontinue if adverse reactions occur. Recent (within week prior to surgery) use of >3 doses of opioids; monitor for GI events. Japanese patients (monitor). Pregnancy. Nursing mothers.
Opioid antagonist (peripheral).
Available only to hospitals that enroll in the Alvimopan REMS Program. For more information, and to enroll, call (800) 278-0340.