Leukemias, lymphomas, and other hematologic cancers:
Indications for CAMPATH:
B-cell chronic lymphocytic leukemia (B-CLL).
Premedicate with antihistamine and acetaminophen before 1st dose, and at dose escalations. Give by IV infusion over 2hrs. Initially 3mg daily until infusion reactions are ≤ grade 2, then increase to 10mg daily until infusion reactions are ≤ grade 2, then to maintenance 30mg/day three times per week (on alternate days); duration of therapy (including escalation): 12 weeks. Do not exceed max single dose 30mg/dose or 90mg/week. Give PCP and herpes viral prophylaxis during treatment and for at least 2 months after completion or until CD4+ count ≥200cells/µL, whichever occurs later. Dose adjustments for neutropenia and thrombocytopenia: see full labeling. Retitrate if therapy interrupted for ≥7 days.
Cytopenias. Infusion reactions. Infections.
Withhold dose for severe cytopenias (except lymphopenia); discontinue if autoimmune or recurrent/persistent severe cytopenias (except lymphopenia) develop. Monitor for infusion reactions; withhold dose if grade 3 or 4. Monitor for CMV infection during and for at least 2 months after completion. Withhold dose for serious infections and during antiviral treatment for CMV infection or confirmed CMV viremia. Obtain CBCs, platelet counts weekly, assess CD4+ counts after treatment until recovery to ≥200cells/µL. Pregnancy: exclude status prior to initiation. Advise females of reproductive potential to use effective contraception during and for at least 3 months after the last dose. Nursing mothers: not recommended (during and for at least 3 months after the last dose).
Monoclonal antibody, CD52 (recombinant, humanized).
Avoid live virus vaccines (after recent alemtuzumab therapy) to patients or infants born to patients receiving treatment. May interfere with tests using antibodies. Irradiate any blood products given (GVHD may occur).
Infusion reactions, cytopenias (eg, neutropenia, lymphopenia, thrombocytopenia, anemia), infections (eg, CMV), nausea, emesis, diarrhea, insomnia, anxiety.
Mean half-life: 11 hours (after the first dose); 6 days (after the last dose).
Single-use vial—1, 3