Leukemias, lymphomas, and other hematologic cancers:
Indications for ASPARLAS:
Treatment of acute lymphoblastic leukemia as a component of a multi-agent chemotherapeutic regimen.
Adults and Children:
<1month: not established. 1month–21yrs: Give by IV infusion over 1hr. 2500 Units/m2 no more frequently than every 21 days. Dose modifications: see full labeling.
History of serious thrombosis, pancreatitis, or hemorrhagic events with prior L-asparaginase therapy. Severe hepatic impairment.
Have resuscitation equipment available and observe patient for 1hr post-dose. Assess serum amylase and/or lipase levels. Discontinue if serious hypersensitivity reactions, thrombotic events, or pancreatitis occur. Evaluate for hemorrhage with coagulation parameters. Evaluate LFTs at least weekly, during and for ≥6 weeks after last dose. Discontinue and treat if hepatotoxicity occurs. Pregnancy: avoid; exclude status prior to initiation. Advise females of reproductive potential to use effective non-oral contraception (including barrier method) during and for ≥3 months after last dose. Nursing mothers: not recommended (during and for 3 months after last dose).
Avoid concomitant oral contraceptives.
Elevated transaminases, increased bilirubin, pancreatitis, abnormal clotting, diarrhea, hypersensitivity, embolic/thrombotic events, sepsis, dyspnea, hemorrhages.
Single-dose vial (5mL)—1