Diabetes

Semaglutide vs Dulaglutide for HbA1c, Body Weight Reduction in T2D

Semaglutide vs Dulaglutide for HbA1c, Body Weight Reduction in T2D

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Semaglutide was associated with HbA1c and body weight reductions compared with patients taking dulaglutide.

High-Intensity Statins Do Not Worsen Glucose Homeostasis in Type 2 Diabetes

High-Intensity Statins Do Not Worsen Glucose Homeostasis in Type 2 Diabetes

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The effect of high-intensity statins compared with low-intensity statins on glycemic control was examined.

Exenatide Shows Efficacy in Improving Renal Outcomes in T2D

Exenatide Shows Efficacy in Improving Renal Outcomes in T2D

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Investigators examined the effect of exenatide on estimated glomerular filtration rate, new macroalbuminuria, and 2 renal composites.

Empagliflozin Reduces Risk for Nephropathy Regardless of Blood Pressure, LDL Cholesterol, HbA1c

Empagliflozin Reduces Risk for Nephropathy Regardless of Blood Pressure, LDL Cholesterol, HbA1c

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Investigators examined renal outcomes when controlling cardiovascular risk factors, such as blood pressure, LDL-C, and HbA1c.

Continuous Glucose Monitoring Controls Hypoglycemia Better Than Glucometer

Continuous Glucose Monitoring Controls Hypoglycemia Better Than Glucometer

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Participants completed surveys for fear of hypoglycemia, hypoglycemia unawareness, and problem areas in diabetes questionnaire.

Elevated Triglycerides, Diabetes May Be Predictors Major Cardiovascular Events

Elevated Triglycerides, Diabetes May Be Predictors Major Cardiovascular Events

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Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.

Implantable Continuous Glucose Monitoring Device Safe, Effective for Adolescents

Implantable Continuous Glucose Monitoring Device Safe, Effective for Adolescents

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The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.

Treatment for Necrobiosis Lipoidica Gets Orphan Drug Designation

Treatment for Necrobiosis Lipoidica Gets Orphan Drug Designation

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The FDA has granted Orphan Drug Designation to PCS499 (Processa Pharmaceuticals) for the treatment of necrobiosis lipoidica.

First CGM System With Implantable Glucose Sensor Approved

First CGM System With Implantable Glucose Sensor Approved

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The sensor is coated with a fluorescent chemical which produces a small amount of light when exposed to blood glucose.

Increased Risk for Parkinson Disease in Individuals With Type 2 Diabetes

Increased Risk for Parkinson Disease in Individuals With Type 2 Diabetes

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A retrospective cohort study was conducted to determine whether individuals with preexisting type 2 diabetes are at increased risk of developing Parkinson disease.

Information-Motivation-Behavioral Skills Model Identifies Barriers to Diabetes Medication Adherence

Information-Motivation-Behavioral Skills Model Identifies Barriers to Diabetes Medication Adherence

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Investigators used the Information-Motivation-Behavioral skills model of adherence to examine associations between patient characteristics and barriers to adherence to treatment for type 2 diabetes.

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

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In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.

Empagliflozin, Linagliptin Combination Therapy vs Linagliptin Monotherapy for Type 2 Diabetes

Empagliflozin, Linagliptin Combination Therapy vs Linagliptin Monotherapy for Type 2 Diabetes

Investigators examined the safety and efficacy of empagliflozin 10mg and linagliptin 5 mg in patients uncontrolled on linagliptin.

Kidney Function Decline Occurs Nearly Twice as Fast in Diabetes

Kidney Function Decline Occurs Nearly Twice as Fast in Diabetes

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Long-term kidney disease trajectories were examined in patients with and without diabetes.

Emotional Hyper-Reactivity and Cardiometabolic Risk in Remitted Bipolar Disorder

Emotional Hyper-Reactivity and Cardiometabolic Risk in Remitted Bipolar Disorder

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Patients with remitted bipolar disorder and emotional hyper-reactivity also have significantly higher levels of low-grade inflammation, hypertension, and impaired glucose metabolism, indicating a higher risk for cardiometabolic dysfunction.

Single Blood Sample Highly Predictive for Subsequent Diabetes Diagnosis

Single Blood Sample Highly Predictive for Subsequent Diabetes Diagnosis

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A recent study supports the clinical use of a combination of fasting glucose and HbA1c levels from a single blood sample to identify undiagnosed diabetes.

LV Strain, Hypertrophy Predict Heart Failure in Asymptomatic T2D

LV Strain, Hypertrophy Predict Heart Failure in Asymptomatic T2D

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Impaired global longitudinal strain and left ventricular hypertrophy may be predictive of incident heart failure in patients with asymptomatic type 2 diabetes.

AMA: Federal Government Must Tackle Rising Insulin Prices

AMA: Federal Government Must Tackle Rising Insulin Prices

U.S. officials need to take action to control spiking insulin prices, the American Medical Association says.

IV Fluid Infusion Rates Do Not Affect Pediatric DKA Neurologic Outcomes

IV Fluid Infusion Rates Do Not Affect Pediatric DKA Neurologic Outcomes

Neurologic outcomes in children with diabetic ketoacidosis are similar regardless of the rate of administration or the sodium chloride content of intravenous fluids.

Cancer Development Linked to Increased Diabetes Risk

Cancer Development Linked to Increased Diabetes Risk

Researchers examined whether development of cancer is associated with an increased risk of subsequent diabetes in a nationally representative sample of the Korean population.

Diabetes Exposure in Utero and Risk of Developing T2D in Offspring

Diabetes Exposure in Utero and Risk of Developing T2D in Offspring

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This study demonstrated the importance of early screening and diagnosis of type 2 diabetes in mothers and their offspring.

Pre-Pregnancy Programs May Improve Outcomes in Women With Type 2 Diabetes

Pre-Pregnancy Programs May Improve Outcomes in Women With Type 2 Diabetes

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Investigators developed a community-based pre-pregnancy care program to improve pregnancy outcomes.

FDA Clears Omnipod DASH System for Diabetes Management

FDA Clears Omnipod DASH System for Diabetes Management

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The Omnipod DASH system consists of a discreet, tubeless, waterproof Pod which is worn on the body, and the Personal Diabetes Manager (PDM), a handheld wireless device used to control the Pod.

Cardiovascular Mortality in Individuals With Early-, Late-Onset Prediabetes

Cardiovascular Mortality in Individuals With Early-, Late-Onset Prediabetes

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Investigators examined the frequency of cardiovascular vs noncardiovascular deaths in individuals who developed prediabetes that did not progress to diabetes.

Tailored Letter May Improve Gestational Weight Gain in Gestational Diabetes

Tailored Letter May Improve Gestational Weight Gain in Gestational Diabetes

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A tailored electronic health record letter may improve gestational weight gain and reduce postpartum weight retention.

Elevated HbA1c Usually Leads to Prompt Treatment Stratification, Intensification

Elevated HbA1c Usually Leads to Prompt Treatment Stratification, Intensification

Most patients are newly initiated on antidiabetic therapy or have antidiabetic therapy intensified within six months of hemoglobin A1c elevation.

Blood Glucose Levels Unaffected by Non-Nutritive Sweeteners

Blood Glucose Levels Unaffected by Non-Nutritive Sweeteners

Researchers analyzed 29 randomized controlled trials with 741 participants to quantitatively synthesize evidence on the glycemic impact of NNSs.

2003 to 2014 Saw Rise in Diabetic Ketoacidosis Admissions

2003 to 2014 Saw Rise in Diabetic Ketoacidosis Admissions

Researchers examined the incidence and costs of hospital admissions associated with diabetic ketoacidosis admissions.

Gestational Diabetes May Indicate Future Subclinical Renal Issues

Gestational Diabetes May Indicate Future Subclinical Renal Issues

The researchers found that, compared with women without gestational diabetes or subsequent diabetes, women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate.

Findings Do Not Support Glyburide as First-Line Treatment for Gestational Diabetes

Findings Do Not Support Glyburide as First-Line Treatment for Gestational Diabetes

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Findings do not support noninferiority of glyburide for prevention of perinatal complications of gestational diabetes.

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