SPRINT Update: Positive CVD Outcomes With Intensive Blood Pressure Management in Prediabetes
The effects of intensive vs standard blood pressure treatment were examined in patients with prediabetes.
HealthDay News — The beneficial effects of intensive systolic blood pressure (SBP) treatment are similar among those with prediabetes and fasting normoglycemia, according to a study published online in Diabetes Care.
Adam P. Bress, PharmD, from the University of Utah in Salt Lake City, and colleagues conducted a post hoc analysis of data from the Systolic Blood Pressure Intervention Trial (SPRINT; ClincialTrials.gov identifier NCT01206062). The study assessed the effects of intensive (<120 mmHg) compared with standard (<140 mmHg) SBP treatment among 3898 patients with prediabetes (fasting serum glucose ≥100 mg/dL) vs 5425 patients with fasting normoglycemia (fasting serum glucose <100 mg/dL) at baseline.
The researchers found that over a median 3.26 years of follow-up, the hazard ratio for the primary outcome of composite cardiovascular disease (CVD) outcomes (myocardial infarction [MI], acute coronary syndrome not resulting in MI, stroke, acute decompensated heart failure, or death from CVD causes) was 0.69 (95% CI, 0.53-0.89) among those with prediabetes and 0.83 (95% CI, 0.66-1.03) in those with normoglycemia (P for interaction =.3). The hazard ratio for all-cause mortality with intensive SBP treatment was 0.77 (95% CI, 0.55-1.06) for prediabetes and 0.71 (95% CI, 0.54-0.94) for normoglycemia (P for interaction =.74). The effects of intensive vs standard SBP treatment were not significant for prespecified renal outcomes and serious adverse events.
"The current SPRINT analysis demonstrates that the beneficial effects of intensive SBP treatment on CVD events and all-cause mortality extend to patients with prediabetes," the authors write.
Disclosures: Several authors disclosed financial ties to pharmaceutical companies, including Takeda, which provided study medications.
Bress AP, King JB, Kreider KE, et al; for the SPRINT research group. Effect of intensive versus standard blood pressure treatment according to baseline prediabetes status: a post hoc analysis of a randomized trial [published online August 2017]. Diabetes Care. doi:10.2337/dc17-0885