Recent-Onset Diabetes Tied to Increased Pancreatic Cancer Risk
Latinos, African-Americans with recent-onset disease have higher risk than those with long-term disease
HealthDay News -- Recent-onset diabetes is associated with more than a two-fold greater increase in risk of pancreatic cancer (PC) than long-standing diabetes in African-Americans and Latinos, according to a study published online June 18 in the Journal of the National Cancer Institute.
Veronica Wendy Setiawan, Ph.D., from the University of Southern California in Los Angeles, and colleagues examined the relationships between recent-onset diabetes and PC incidence in 48,995 African-Americans and Latinos in the Multiethnic Cohort (baseline 1993 to 1996).
The researchers found that 32.3 percent of participants developed diabetes between baseline and 2013, and 408 incident PC cases were identified during follow-up. Diabetes was associated with PC (hazard ratio [HR] at age 75 years, 2.39). For individuals with onset of diabetes within three years of PC diagnosis, there was greater risk compared with those with long-term diabetes across all ages. At age 75 years, the HR for recent-onset diabetes was 4.08 in Latinos and 3.38 in African-Americans.
"Our findings support the hypothesis that recent-onset diabetes is a manifestation of PC and that long-standing diabetes is a risk factor for this malignancy," the authors write.