Gestational Diabetes May Indicate Future Subclinical Renal Issues

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When adjusting for prepregnancy body mass index and hypertension, among other potential confounders, gestational diabetes without subsequent diabetes was not related to UACR.
When adjusting for prepregnancy body mass index and hypertension, among other potential confounders, gestational diabetes without subsequent diabetes was not related to UACR.

HealthDay News — Gestational diabetes (GD) may be an early indicator of subsequent subclinical renal dysfunction, according to a study published in Diabetes Care.

Shristi Rawal, Ph.D., from the National Institutes of Health in Bethesda, Md., and colleagues used data from the Diabetes & Women's Health study (2012 to 2016) to examine the independent and joint associations of GD and subsequent diabetes with long-term renal function among 607 women and 619 women without GD participating in the Danish National Birth Cohort (1996 to 2002).

The researchers found that, compared with women without GD or subsequent diabetes, women with a history of GD had significantly higher estimated glomerular filtration rate, even if they had not subsequently developed diabetes.

Women with a GD history who later developed diabetes (183 women) also had a significantly higher urinary albumin-to-creatinine ratio (UACR) and an increased risk of elevated UACR (adjusted relative risk, 2.3) versus women with neither. When adjusting for prepregnancy body mass index and hypertension, among other potential confounders, GD without subsequent diabetes was not related to UACR.

"These findings suggest that women with GD-complicated pregnancies may represent a high-risk group that could benefit from regular monitoring for early-stage renal damage, timely detection of which may help clinicians initiate treatment to prevent or delay further disease progression," the authors write.

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