Hepatic Fat, Glycogen Stores Increased With High Glycemic Index Diet

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A high glycemic index diet increased hepatic fat and glycogen stores.
A high glycemic index diet increased hepatic fat and glycogen stores.

HealthDay News -- A 1-week high glycemic index diet increases hepatic fat and glycogen stores in healthy adults compared with a low glycemic index diet, according to a study published online September 4 in Diabetes, Obesity and Metabolism.

Stephen Bawden, PhD, from the University of Nottingham in the United Kingdom, and colleagues examined the acute and long-term effects of low glycemic index and high glycemic index diets in healthy volunteers. Eight healthy males underwent testing before and after a 7-day macronutrient and energy matched high glycemic index or low glycemic index diet, followed by a minimum 4-week washout period, and repetition of the intervention with the alternative diet.

The researchers found that following the high glycemic index vs low glycemic index test meal, there were significantly greater plasma glucose and insulin peak values and area under the curve. Following the high glycemic index test meal, there was a greater increase in hepatic glycogen concentrations (P<.05); compared with the beginning of the intervention, peak levels were significantly greater after 7 days of high glycemic index dietary intervention (P<.05). There was a significant increase in liver fat fractions after the high glycemic index vs low glycemic index intervention.

"Compared to an low glycemic index diet, a 1-week high glycemic index diet increased hepatic fat and glycogen stores," the researchers wrote. "This may have important clinical relevance for dietary interventions in the prevention and management of nonalcoholic fatty liver disease."

Disclosure: Several authors disclosed financial ties to Unilever.

Reference

  1. Bawden S, Stephenson M, Falcone Y, et al. Increased liver fat and glycogen stores following high compared with low glycaemic index food: a randomized cross over study. Diabetes Obes Metab. 2016. doi:10.1111/dom.12784.
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