Low-Grade Inflammatory Markers May Help Differentiate Diabetes Diagnoses in Adults
Latent autoimmune diabetes in adults vs classic adult-onset type 1 diabetes was independently related to soluble tumor necrosis factor-a receptor 2 and high-sensitivity C-reactive protein levels.
Serum concentrations of adiposity-related low-grade inflammatory mediators may help to differentiate the diagnosis of latent autoimmune diabetes in adults (LADA) from that of classic adult-onset type 1 diabetes and type 2 diabetes, according to a cross-sectional study published in Diabetes Care.1
"If the performance of these models is externally validated in independent populations, they may have potential clinical utility to identify individuals with higher odds of having LADA than classic adult-onset type 1 diabetes or type 2 diabetes, along with islet autoantibody positivity," recommended the authors.1
- Castelblanco E, Hernández M, Castelblanco A, et al. Low-grade inflammatory marker profile may help to differentiate patients with LADA, classic adult-onset type 1 and type 2 diabetes. Diabetes Care. 2018;41:dc171662.
- Naik RG, Brooks-Worrell BM, Palmer JP. Latent autoimmune diabetes in adults. J Clin Endocrinol Metab. 2009;94:4635-4644.
- Mollo A, Hernandez M, Marsal JR, et al; Action LADA 8. Latent autoimmune diabetes in adults is perched between type 1 and type 2: evidence from adults in one region of Spain [published correction appears in Diabetes Metab Res Rev. 2013;29:693]. Diabetes Metab Res Rev. 2013;29:446-451.