Diabetes Complications

Noninferior CV Outcomes for Linagliptin in T2D With High CV, Renal Risk

Noninferior CV Outcomes for Linagliptin in T2D With High CV, Renal Risk

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Linagliptin added to usual care compared with placebo added to usual care resulted in a noninferior risk for a composite cardiovascular or renal outcome over a median 2.2 years.

Dapagliflozin Lowers Heart Failure Hospitalization Rates in High-Risk Patients With Diabetes

Dapagliflozin Lowers Heart Failure Hospitalization Rates in High-Risk Patients With Diabetes

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Dapagliflozin was not associated with either a higher or lower rate of MACE compared with placebo in patients with type 2 diabetes who had or were at risk for atherosclerotic cardiovascular disease.

Empagliflozin Effectively Reduces Risk for Heart Failure Hospitalization in T2D

Empagliflozin Effectively Reduces Risk for Heart Failure Hospitalization in T2D

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Approximately 50% of deaths in people with type 2 diabetes worldwide, and approximately two-thirds of deaths in people with type 2 diabetes in the US are caused by cardiovascular disease.

Acute and Persistent Prothrombic Effects Observed With Antecedent Hypoglycemia in T2D

Acute and Persistent Prothrombic Effects Observed With Antecedent Hypoglycemia in T2D

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Hypoglycemia was associated with early and late prothrombotic changes in the fibrin network in individuals with type 2 diabetes.

Extra-Glycemic Effects May Explain Different CV Outcomes With Dapagliflozin, Vildagliptin

Extra-Glycemic Effects May Explain Different CV Outcomes With Dapagliflozin, Vildagliptin

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Dapaglifozin and vildagliptin impact cardio-metabolic processes differently.

Measuring Time in Range During CGM May Be Useful Outcome Metric for Clinical Trials

Measuring Time in Range During CGM May Be Useful Outcome Metric for Clinical Trials

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TIR is strongly associated with the risk of microvascular complications and should be an acceptable end point for clinical trials.

Patients With T2D and Sickle-Cell Trait at Higher Risk for Complications

Patients With T2D and Sickle-Cell Trait at Higher Risk for Complications

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Diabetic complications were more prevalent in patients with both sickle-cell trait and T2D than in patients with T2D alone.

AHA, ADA Announce Joint Education Initiative to Reduce CVD Deaths in T2D

AHA, ADA Announce Joint Education Initiative to Reduce CVD Deaths in T2D

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The ADA and the AHA launch a long-term awareness and education initiative for the prevention of deaths due to cardiovascular complications in patients with T2D.

Diabetes Education Week 2018: Patient Resources for Your Practice

Diabetes Education Week 2018: Patient Resources for Your Practice

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In recognition of National Diabetes Education Week, Endocrinology Advisor compiled a list of resources to assist clinicians when educating patients with diabetes about their condition.

Intensive BP, Lipid Control in T2D May Increase Risk for Adverse Kidney Events

Intensive BP, Lipid Control in T2D May Increase Risk for Adverse Kidney Events

Intensive BP control and fenofibrate use in patients with T2D who are at high risk for CVD may increase the risk for adverse kidney events.

Bardoxolone Methyl Leads to Weight Loss in T2D with Concurrent Chronic Kidney Disease

Bardoxolone Methyl Leads to Weight Loss in T2D with Concurrent Chronic Kidney Disease

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Treatment with bardoxolone methyl resulted in significant weight loss and showed no evidence of muscle wasting in patients with type 2 diabetes and stage IV chronic kidney disease.

Dose-Dependent Relationship Between Smoking and Cardiovascular Complications in T1D

Dose-Dependent Relationship Between Smoking and Cardiovascular Complications in T1D

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There is a dose-dependent association between smoking and coronary heart disease in patients with type 1 diabetes.

Severity of Metabolic Syndrome Indicates Risk for T2D, CVD in Prediabetes Treatment

Severity of Metabolic Syndrome Indicates Risk for T2D, CVD in Prediabetes Treatment

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Researchers analyzed how improvements in metabolic syndrome may impact the risk of developing type 2 diabetes and cardiovascular disease in patients with prediabetes.

Deep Learning Algorithm Efficiently Detects Vision-Threatening Diabetic Retinopathy

Deep Learning Algorithm Efficiently Detects Vision-Threatening Diabetic Retinopathy

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The artificial intelligence-based deep learning algorithm shows robust performance in the detection of vision-threatening referable diabetic retinopathy.

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

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Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.

Empagliflozin Treatment Positively Impacts Life Expectancy in T2D With CVD

Empagliflozin Treatment Positively Impacts Life Expectancy in T2D With CVD

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For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.

Elevated HbA1c After Onset of T1D Predicts Psychiatric Comorbidity

Elevated HbA1c After Onset of T1D Predicts Psychiatric Comorbidity

High average glycated hemoglobin levels during the first two years after type 1 diabetes onset predict higher risk for psychiatric diagnoses.

SGLT2 Inhibitors Associated With Increased Risk for Genital Infections

SGLT2 Inhibitors Associated With Increased Risk for Genital Infections

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SGLT2 inhibitors were associated with an approximately 3-fold higher risk for developing genital infections.

CPAP Therapy for Sleep Apnea Does Not Improve Diabetic Macular Edema in T2D

CPAP Therapy for Sleep Apnea Does Not Improve Diabetic Macular Edema in T2D

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Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.

Time in Range According to CGM Associated With Diabetic Retinopathy

Time in Range According to CGM Associated With Diabetic Retinopathy

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Investigators assessed the time in range according to a continuous glucose monitor and the risk for diabetic retinopathy.

Bullous Pemphigoid Risk in Patients With Diabetes Treated With DPP-4 Inhibitors

Bullous Pemphigoid Risk in Patients With Diabetes Treated With DPP-4 Inhibitors

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The association between DPP-4 inhibitor use and the risk for developing bullous pemphigoid was examined.

Update on the T2D-Dementia Link: Interview With Experts

Update on the T2D-Dementia Link: Interview With Experts

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Endocrinology Advisor interviewed experts to explore mechanisms, clinical implications, and research needs pertaining to the diabetes-dementia link.

Association Between Urine Complement Proteins and Kidney Disease, Mortality in T2D

Association Between Urine Complement Proteins and Kidney Disease, Mortality in T2D

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Researchers suggest complement pathway activation plays a role in diabetic kidney disease progression in people with proteinuria.

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

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Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.

FDA to Review Eylea for the Treatment of Non-Proliferative Diabetic Retinopathy

FDA to Review Eylea for the Treatment of Non-Proliferative Diabetic Retinopathy

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The sBLA includes results from the Phase 3 PANORAMA trial, which enrolled 402 patients with NPDR.

Diabetic Retinopathy Risk Not Increased With GLP-1 Receptor Agonist Use in T2D

Diabetic Retinopathy Risk Not Increased With GLP-1 Receptor Agonist Use in T2D

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Investigators examined whether the use of glucagon-like peptide-1 receptor agonists is associated with an increased risk for incident diabetic retinopathy.

Concurrent Risk Factors and Microvascular Complications in Type 1 Diabetes

Concurrent Risk Factors and Microvascular Complications in Type 1 Diabetes

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Investigators assessed the effect of complication burden and concurrent risk factors level on the risk of developing further microvascular complication.

Bariatric Surgery Reduces Incidence of Microvascular Disease in Type 2 Diabetes

Bariatric Surgery Reduces Incidence of Microvascular Disease in Type 2 Diabetes

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Investigators examined the effect of bariatric surgery and the incidence of microvascular complications in type 2 diabetes.

Treating Painful Diabetic Peripheral Neuropathy With Electroacupuncture

Treating Painful Diabetic Peripheral Neuropathy With Electroacupuncture

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Investigators sought to determine the safety and efficacy of electroacupuncture for painful diabetic peripheral neuropathy.

Estimating Risk Factors and Trajectories for Diabetic Polyneuropathy

Estimating Risk Factors and Trajectories for Diabetic Polyneuropathy

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Investigators examined cardiometabolic risk factor trajectories in patients diagnosed with type 2 diabetes over the course of 13 years preceding diabetic polyneuropathy.

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