Cardiovascular and Metabolic Disorders
Children and adolescents with metabolically healthy obesity had higher carotid intima-media thickness compared with metabolically healthy individuals who were a normal weight.
Reducing triglyceride levels in patients with type 2 diabetes may help them attain more optimal glycemic control.
Among individuals at a high risk for cardiovascular disease, a panel of short- and long-chain acylcarnitines was significantly associated with the incidence of type 2 diabetes.
The addition of ezetimibe to simvastatin reduced ischemic risk compared with placebo, with consistent relative risk reductions in patients with and without polyvascular disease.
The American College of Cardiology published an expert consensus statement regarding decision considerations for novel cardiovascular risk reduction therapies in patients with type 2 diabetes and atherosclerotic cardiovascular disease.
Coronary Bypass Grafting Superior to Percutaneous Coronary Intervention With Drug-Eluting Stents for Reducing Mortality in DiabetesNovember 27, 2018
Coronary artery bypass grafting may be a superior revascularization strategy in patients with diabetes and multivessel disease.
In high-risk patients with mild hypertriglyceridemia, omega-3 fatty acids improved triglyceride levels and reduced major adverse cardiovascular events, according to a new meta-analysis.
Researcher observed a much lower rate of discontinuations due to skeletal muscle events with alirocumab in the open-label extension trial compared with the double-blind parent study (3.2% vs 15.9%).
In patients with primary hypercholesterolemia, short-term treatment with simvastatin improved the lipid profile and exerted a beneficial effect on a wide range of proatherogenic and prothrombotic parameters.
Icosapent Ethyl Reduces Ischemic Event Risk in Patients With Hypertriglyceridemia Despite Statin UseNovember 16, 2018
The risk for the primary composite endpoint was significantly lowered by 25% among patients who received 2g of icosapent ethyl twice daily vs those who received placebo.
A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course.
Evolocumab consistently reduced LDL-C with no increase in adverse events over a 5-year study period.
First-year nonadherence and discontinuation are high among older adults prescribed statins.
The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.
Women entering menopause had patterns of cardiometabolic risk components related to race/ethnicity.
Early detection of lipidome characteristics could help identify the early onset of type 2 diabetes.
Skin disorders, particularly those with known inflammatory mechanisms, may be considered potential early markers for the development of insulin resistance leading to metabolic syndrome, type 2 diabetes, and cardiovascular disease.
There is a lack of convincing evidence for an association between statin use and noncardiovascular disease outcomes.
Statin therapy is associated with reduced mitochondrial complex II-linked respiration, and statin-induced myalgia is coupled to an increased intrinsic mitochondrial respiratory function, while intramuscular [coenzyme Q10] levels are unaltered.
A therapeutic lifestyle change (TLC) intervention plus motivational interviewing (MINT) sessions delivered in churches can reduce systolic blood pressure (BP) among blacks compared with health education (HE) alone.
Investigators examine the association between depression and metabolic syndrome, factoring in diet and physical activity.
The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.
Tibia lead levels are associated with resistant-hypertension.
Type 2 diabetes is an independent risk factor for sudden cardiac arrest and death in patients with coronary artery disease with preserved ejection fraction.
For adults with treated hypertension, periodontitis is associated with higher mean systolic blood pressure and with increased odds of unsuccessful hypertensive treatment.
The randomized, double-blind, placebo-controlled, parallel-group study (N = 9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.
Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.
For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery.
Supplementation with coenzyme Q10 may be an effective approach for managing statin-induced myopathy.
Excess cardiovascular disease mortality persisted for many years after thyroid-ablative treatment in patients who received radioactive iodine who did not become hypothyroid.
Endocrinology Advisor Articles
- Diet Quality and Glycemic Control in Women With Gestational Diabetes
- Most Foods Containing Fructose Do Not Have Harmful Effect on Glycemic Control
- Effects of a Low-Carbohydrate Diet on Weight Loss Maintenance
- Sleep Quality in Women With Surgical vs Natural Menopause
- Unhealthy Lifestyle and Rotating Night Shifts Put Nurses at Higher Risk for T2D
- Serious Adverse Events Linked to SGLT2 Inhibitors
- Endocrine-Disrupting Chemicals in Personal Care Products Linked to Early Puberty
- History of Partner Violence Tied to Menopause Symptoms
- Patients Commonly Withhold Medically Relevant Information From Clinicians
- "Gender Panic" in Clinical Settings: Protecting Public Accommodations Access for Transgender Individuals