Cardiovascular and Metabolic Disorders

Metabolically Healthy Obese Children, Adolescents at Higher Risk for CVD

Metabolically Healthy Obese Children, Adolescents at Higher Risk for CVD

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Children and adolescents with metabolically healthy obesity had higher carotid intima-media thickness compared with metabolically healthy individuals who were a normal weight.

Elevated Triglyceride Levels Affect Glycemic Control in Type 2 Diabetes

Elevated Triglyceride Levels Affect Glycemic Control in Type 2 Diabetes

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Reducing triglyceride levels in patients with type 2 diabetes may help them attain more optimal glycemic control.

Plasma Acylcarnitines May Indicate Risk for Type 2 Diabetes

Plasma Acylcarnitines May Indicate Risk for Type 2 Diabetes

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Among individuals at a high risk for cardiovascular disease, a panel of short- and long-chain acylcarnitines was significantly associated with the incidence of type 2 diabetes.

Ezetimibe Plus Statin Therapy Reduces Ischemic Risk in Polyvascular Disease, T2D

Ezetimibe Plus Statin Therapy Reduces Ischemic Risk in Polyvascular Disease, T2D

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The addition of ezetimibe to simvastatin reduced ischemic risk compared with placebo, with consistent relative risk reductions in patients with and without polyvascular disease.

ACC Releases Recommendations for Treatment of Patients With T2D and ASCVD

ACC Releases Recommendations for Treatment of Patients With T2D and ASCVD

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The American College of Cardiology published an expert consensus statement regarding decision considerations for novel cardiovascular risk reduction therapies in patients with type 2 diabetes and atherosclerotic cardiovascular disease.

Coronary Bypass Grafting Superior to Percutaneous Coronary Intervention With Drug-Eluting Stents for Reducing Mortality in Diabetes

Coronary Bypass Grafting Superior to Percutaneous Coronary Intervention With Drug-Eluting Stents for Reducing Mortality in Diabetes

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Coronary artery bypass grafting may be a superior revascularization strategy in patients with diabetes and multivessel disease.

Omega-3 Fatty Acids Reduce Major CV Events in Mild Hypertriglyceridemia

Omega-3 Fatty Acids Reduce Major CV Events in Mild Hypertriglyceridemia

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In high-risk patients with mild hypertriglyceridemia, omega-3 fatty acids improved triglyceride levels and reduced major adverse cardiovascular events, according to a new meta-analysis.

Alirocumab Well Tolerated and Effective in Patients With Statin Intolerance

Alirocumab Well Tolerated and Effective in Patients With Statin Intolerance

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Researcher observed a much lower rate of discontinuations due to skeletal muscle events with alirocumab in the open-label extension trial compared with the double-blind parent study (3.2% vs 15.9%).

Simvastatin Improves Inflammation, Platelet Activation Markers in Primary Hypercholesterolemia

Simvastatin Improves Inflammation, Platelet Activation Markers in Primary Hypercholesterolemia

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In patients with primary hypercholesterolemia, short-term treatment with simvastatin improved the lipid profile and exerted a beneficial effect on a wide range of proatherogenic and prothrombotic parameters.

Icosapent Ethyl Reduces Ischemic Event Risk in Patients With Hypertriglyceridemia Despite Statin Use

Icosapent Ethyl Reduces Ischemic Event Risk in Patients With Hypertriglyceridemia Despite Statin Use

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The risk for the primary composite endpoint was significantly lowered by 25% among patients who received 2g of icosapent ethyl twice daily vs those who received placebo.

Consensus Guidelines Reinforce Healthy Living for Lowering Cholesterol

Consensus Guidelines Reinforce Healthy Living for Lowering Cholesterol

A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course.

Long-Term Evolocumab Safe and Effective for Treating Hypercholesterolemia

Long-Term Evolocumab Safe and Effective for Treating Hypercholesterolemia

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Evolocumab consistently reduced LDL-C with no increase in adverse events over a 5-year study period.

Nonadherence, Discontinuation High in First Year of Statin Therapy

Nonadherence, Discontinuation High in First Year of Statin Therapy

First-year nonadherence and discontinuation are high among older adults prescribed statins.

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Treatment Examined

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Treatment Examined

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The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.

Cardiometabolic Disease Patterns Related to Race, Ethnicity in Midlife Women

Cardiometabolic Disease Patterns Related to Race, Ethnicity in Midlife Women

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Women entering menopause had patterns of cardiometabolic risk components related to race/ethnicity.

Lipidome Profiles Stratify Risk for Type 2 Diabetes

Lipidome Profiles Stratify Risk for Type 2 Diabetes

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Early detection of lipidome characteristics could help identify the early onset of type 2 diabetes.

Skin Disease and Metabolic Syndrome: Early Warning Signs of a Greater Problem

Skin Disease and Metabolic Syndrome: Early Warning Signs of a Greater Problem

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Skin disorders, particularly those with known inflammatory mechanisms, may be considered potential early markers for the development of insulin resistance leading to metabolic syndrome, type 2 diabetes, and cardiovascular disease.

Lack of Evidence for Noncardiovascular Outcomes With Statin Use

Lack of Evidence for Noncardiovascular Outcomes With Statin Use

There is a lack of convincing evidence for an association between statin use and noncardiovascular disease outcomes.

Statin-Induced Myalgia Unrelated to Muscle Coenzyme Q10 Level

Statin-Induced Myalgia Unrelated to Muscle Coenzyme Q10 Level

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Statin therapy is associated with reduced mitochondrial complex II-linked respiration, and statin-induced myalgia is coupled to an increased intrinsic mitochondrial respiratory function, while intramuscular [coenzyme Q10] levels are unaltered.

Therapeutic Lifestyle Intervention in Church Helpful for Reducing Systolic BP

Therapeutic Lifestyle Intervention in Church Helpful for Reducing Systolic BP

A therapeutic lifestyle change (TLC) intervention plus motivational interviewing (MINT) sessions delivered in churches can reduce systolic blood pressure (BP) among blacks compared with health education (HE) alone.

Diet and Physical Activity Factors in Metabolic Syndrome With Depression

Diet and Physical Activity Factors in Metabolic Syndrome With Depression

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Investigators examine the association between depression and metabolic syndrome, factoring in diet and physical activity.

Canagliflozin Approved to Reduce Risk for Cardiovascular Events in T2D

Canagliflozin Approved to Reduce Risk for Cardiovascular Events in T2D

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The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia lead levels are associated with resistant-hypertension.

Type 2 Diabetes an Independent Risk Factor for Coronary Artery Disease

Type 2 Diabetes an Independent Risk Factor for Coronary Artery Disease

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Type 2 diabetes is an independent risk factor for sudden cardiac arrest and death in patients with coronary artery disease with preserved ejection fraction.

Oral Health Linked to Blood Pressure Profile, Treatment Success During Antihypertensive Therapy

Oral Health Linked to Blood Pressure Profile, Treatment Success During Antihypertensive Therapy

For adults with treated hypertension, periodontitis is associated with higher mean systolic blood pressure and with increased odds of unsuccessful hypertensive treatment.

Saxenda Labeling Updated With Cardiovascular Safety Data

Saxenda Labeling Updated With Cardiovascular Safety Data

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The randomized, double-blind, placebo-controlled, parallel-group study (N = 9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

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Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.

Bariatric Surgery Reduces Macrovascular Complications in Obesity, T2D

Bariatric Surgery Reduces Macrovascular Complications in Obesity, T2D

For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery.

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

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Supplementation with coenzyme Q10 may be an effective approach for managing statin-induced myopathy.

Cardiovascular Disease Risk Persists Years After Treatment of Thyrotoxicosis

Cardiovascular Disease Risk Persists Years After Treatment of Thyrotoxicosis

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Excess cardiovascular disease mortality persisted for many years after thyroid-ablative treatment in patients who received radioactive iodine who did not become hypothyroid.

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