Pulse Pressure Associated With Multiple Adverse Cardiovascular Outcomes

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Pulse pressure is linked to multiple adverse cardiovascular outcomes.
Pulse pressure is linked to multiple adverse cardiovascular outcomes.

(HealthDay News) — Pulse pressure is associated with multiple adverse cardiovascular outcomes, according to a study published in the Journal of the American College of Cardiology.

Senthil Selvaraj, MD, from the Brigham and Women's Hospital Heart and Vascular Center in Boston, and colleagues examined whether pulse pressure is associated with major adverse cardiovascular outcomes in participants from the international Reduction of Atherothrombosis for Continued Health (REACH) registry. 

Data were included for 45 087 participants, excluding those with incomplete 4-year follow-up or pulse pressure data.

The researchers found that the mean blood pressure was 138 ±19/79 ± 11 mm Hg, for a mean pulse pressure of 49 ± 16 mm Hg. Increasing pulse pressure quartile correlated with worse outcomes on univariate analysis (P<.05 for all comparisons). Pulse pressure quartile was still associated with all outcomes except all stroke and cardiovascular death after adjustment for sex, age, current smoking status, history of hypercholesterolemia, history of diabetes, aspirin use, statin use, blood pressure medication use, and mean arterial pressure (P<.05 for all comparisons).

"In an international cohort of high-risk subjects, [pulse presure], a readily available hemodynamic parameter, is associated with multiple adverse cardiovascular outcomes and provides prognostic utility beyond that of mean arterial pressure," the researchers wrote.

Several authors disclosed financial ties to biopharmaceutical companies, including Sanofi and Bristol-Myers Squibb, which sponsored the REACH registry.


  1. Selvaraj S, Steg G, Elbez Y, et al. Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis: From the REACH Registry. J Am Coll Cardiol. 2016;67(4):392-403. doi:10.1016/j.jacc.2015.10.084.
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