Cardiovascular Disease Risk Up in Newly Diagnosed Psoriatic Arthritis
Patients with psoriatic arthritis experience a higher risk for cardiovascular disease.
(HealthDay News) — Many newly diagnosed psoriatic arthritis patients have an increased risk for future cardiovascular disease (CVD), according to a study published in Arthritis Care and Research.
Floranne C. Ernste, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined the prevalence of CVD risk factors at initial onset of psoriatic arthritis and compared the observed incidence of CVD events with that predicted by the Framingham Risk Score (FRS).
Data were included for a cohort of 158 patients with psoriatic arthritis who fulfilled Classification of Psoriatic Arthritis criteria for psoriatic arthritis in 1989 to 2008 (mean age, 43.4 years; 61% men; 44% obese).
At psoriatic arthritis incidence, 34% of patients presented with two or more CVD risk factors, according to the researchers. Of the 126 patients aged at least 30 years at psoriatic arthritis incidence and without prior history of CVD, 33% had a FRS of at least 10%, and 11% had an FRS of at least 20%.
In the first 10 years of disease duration, 18 patients experienced a CVD event. For CVD events, the 10-year cumulative incidence was 17%, significantly higher than the predicted incidence based on the FRS (standardized incidence ratio, 1.80; P= 0.012).
"In summary, our findings demonstrate that patients with newly diagnosed [psoriatic arthritis] have an increased risk for CVD, and the FRS underestimates the magnitude of this risk," the researchers wrote.
The study was funded by Amgen.