ECG Measures May Improve CV Death Prediction in CKD
Using ECG may improve prediction of cardiovascular death in chronic kidney disease.
(HealthDay News) — Certain electrocardiographic (ECG) measures may improve prediction of cardiovascular (CV) death in patients with chronic kidney disease (CKD), according to research published in the Journal of the American Society of Nephrology.
Rajat Deo, MD, of the University of Pennsylvania in Philadelphia, and colleagues analyzed data for a prospective cohort of 3,939 participants with CKD to assess whether common ECG parameters are independent predictors of mortality risk.
ECG metrics were independent markers for risk for CV death, including PR interval ≥200 ms (HR=1.62; 95% CI, 1.19-2.19); QRS interval 100 ms to 119 ms (HR=1.64; 95% CI, 1.20-2.25) and ≥120 ms (HR=1.75; 95% CI, 1.17-2.62); corrected QT interval ≥450 ms in men or ≥460 ms in women (HR=1.72; 95% CI, 1.19-2.49); and heart rate ≥90 beats per minute (HR=2.35; 95% CI, 1.03-5.33).
Most ECG metrics were stronger markers of risk for CV death than for non-CV death or all-cause mortality. Adding these markers to a comprehensive model of cardiorenal risk factors significantly increased the C-statistic for CV death from 0.77 to 0.81.
"These data suggest common ECG metrics are independent risk factors for cardiovascular death and enhance the ability to predict death events in a population with CKD," the researchers wrote.