CV Autonomic Neuropathy Predicts Urological Issues
CV Autonomic Neuropathy Predicts Urological Issues in Type 1 Diabetes
(HealthDay News) — For men with type 1 diabetes, cardiovascular (CV) autonomic neuropathy is associated with erectile dysfunction and/or lower urinary tract symptoms, according to a study published in The Journal of Urology.
Rodica Pop-Busui, MD, PhD, from the University of Michigan in Ann Arbor, and colleagues examined the correlation between CV autonomic neuropathy and erectile dysfunction and/or lower urinary tract symptoms.
Data were obtained for 635 men in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) with type 1 diabetes. Analyses were adjusted for time-weighted glycemic control, blood pressure, age and other covariates.
The researchers found that, compared with men without erectile dysfunction or lower urinary tract symptoms, those with erectile dysfunction and/or lower urinary tract symptoms had significantly lower respiratory rate variation and Valsalva ratio at DCCT closeout and EDIC year 16/17.
The odds of erectile dysfunction and lower urinary tract symptoms were increased 2.65-fold among participants with CV autonomic neuropathy, in adjusted analysis.
"These data suggest that cardiovascular autonomic neuropathy predicts the development of urological complications in men with long-standing type 1 diabetes," the researchers wrote. "Studies evaluating the mechanisms contributing to these interactions are warranted for targeting effective prevention or treatment."
One author disclosed financial ties to the medical device industry.