Cardiovascular and Metabolic Disorders Archive
Postmenopausal women with edentulism are at an increased risk for developing hypertension.
Providers should maximize women's health during the interpregnancy period, continuing care beyond the immediate postpartum period.
Hypercholesterolemic patients who tolerate only lowest-dose statin or non-statin lipid lowering therapy can achieve LDL-C reduction with alirocumab.
Knitting is both process- and product-oriented, encompassing repetitive tasks that can exercise physical and cognitive skills
Very few U.S. adults are metabolically healthy.
Adherent patients receiving high-intensity statin and/or ezetimibe therapy have the lowest cardiovascular risk.
Abdominal fatness in adolescence was associated with cardiometabolic dysfunction and BMI was found to be a beneficial tool for predicting effects of abdominal fat over time.
Metabolic syndrome and psoriatic arthritis were highly prevalent comorbidities in patients with plaque psoriasis.
Guidelines should incorporate using higher 10-year risk thresholds when recommending statins for the purpose of primary CVD prevention.
SYNTAX Score: A Predictive Scale for Adverse CV Events in Patients With Diabetes, CAD Undergoing PCI
SYNTAX score, a validated prediction score used to estimate risk with PCI, is modestly correlated with hard cardiovascular events and is significantly correlated with major adverse cardiac and cerebrovascular events
Ezetimibe combined with statin therapy showed modest or moderate benefits in reducing major CVD event risk.
Fresenius Kabi announced the availability of Omegaven (fish oil triglycerides) injectable emulsion as a source of calories and fatty acids for pediatric patients with parenteral nutrition-associated cholestasis.
The data showed a <0.1% risk of statin-induced muscle injury, including rhabdomyolysis, and a ~0.001% risk of serious hepatotoxicity. Statin-induced newly diagnosed diabetes mellitus was a ~0.2% risk per year of treatment, depending on baseline risk in the patients studied.
Postpartum women with an elevated BMI score and a history of hypertensive disorders during pregnancy have an increased risk of developing type 2 diabetes.
Children and adolescents with metabolically healthy obesity had higher carotid intima-media thickness compared with metabolically healthy individuals who were a normal weight.
Among individuals at a high risk for cardiovascular disease, a panel of short- and long-chain acylcarnitines was significantly associated with the incidence of type 2 diabetes.
Reducing triglyceride levels in patients with type 2 diabetes may help them attain more optimal glycemic control.
Statin use is associated with better cortical bone characteristics in older women with osteoporosis, but results are dependent upon the potency of the statins.
The addition of ezetimibe to simvastatin reduced ischemic risk compared with placebo, with consistent relative risk reductions in patients with and without polyvascular disease.
Socioeconomically challenged patients with obesity and elevated cardiovascular risk may benefit from digital obesity treatment combined with health system resources.
The American College of Cardiology published an expert consensus statement regarding decision considerations for novel cardiovascular risk reduction therapies in patients with type 2 diabetes and atherosclerotic cardiovascular disease.
Coronary Bypass Grafting Superior to Percutaneous Coronary Intervention With Drug-Eluting Stents for Reducing Mortality in Diabetes
Coronary artery bypass grafting may be a superior revascularization strategy in patients with diabetes and multivessel disease.
A 12-month interdisciplinary lifestyle intervention program for prediabetic and obese patients was found to significantly reduce the risk for development of diabetes and metabolic syndrome.
In high-risk patients with mild hypertriglyceridemia, omega-3 fatty acids improved triglyceride levels and reduced major adverse cardiovascular events, according to a new meta-analysis.
In patients with primary hypercholesterolemia, short-term treatment with simvastatin improved the lipid profile and exerted a beneficial effect on a wide range of proatherogenic and prothrombotic parameters.
Researcher observed a much lower rate of discontinuations due to skeletal muscle events with alirocumab in the open-label extension trial compared with the double-blind parent study (3.2% vs 15.9%).
A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course.
Icosapent Ethyl Reduces Ischemic Event Risk in Patients With Hypertriglyceridemia Despite Statin Use
The risk for the primary composite endpoint was significantly lowered by 25% among patients who received 2g of icosapent ethyl twice daily vs those who received placebo.
Evolocumab consistently reduced LDL-C with no increase in adverse events over a 5-year study period.
The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.
First-year nonadherence and discontinuation are high among older adults prescribed statins.
Women entering menopause had patterns of cardiometabolic risk components related to race/ethnicity.
Early detection of lipidome characteristics could help identify the early onset of type 2 diabetes.
The impurity was identified following laboratory testing conducted by the Food and Drug Administration (FDA); this is the first non-valsartan product that the Agency has found to contain NDEA.
Statin therapy is associated with reduced mitochondrial complex II-linked respiration, and statin-induced myalgia is coupled to an increased intrinsic mitochondrial respiratory function, while intramuscular [coenzyme Q10] levels are unaltered.
There is a lack of convincing evidence for an association between statin use and noncardiovascular disease outcomes.
Investigators examine the association between depression and metabolic syndrome, factoring in diet and physical activity.
A therapeutic lifestyle change (TLC) intervention plus motivational interviewing (MINT) sessions delivered in churches can reduce systolic blood pressure (BP) among blacks compared with health education (HE) alone.
The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.
Type 2 diabetes is an independent risk factor for sudden cardiac arrest and death in patients with coronary artery disease with preserved ejection fraction.
Tibia lead levels are associated with resistant-hypertension.
The randomized, double-blind, placebo-controlled, parallel-group study (N = 9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.
For adults with treated hypertension, periodontitis is associated with higher mean systolic blood pressure and with increased odds of unsuccessful hypertensive treatment.
Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.
For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery.
Supplementation with coenzyme Q10 may be an effective approach for managing statin-induced myopathy.
Excess cardiovascular disease mortality persisted for many years after thyroid-ablative treatment in patients who received radioactive iodine who did not become hypothyroid.
Sexual harassment and sexual assault among midlife women are associated with poorer physical and mental health.
Implementing shared financial incentives between physicians and patients is a cost-effective intervention strategy for controlling LDL-C levels among high-risk patients.
Lorcaserin facilitates sustained weight loss without increasing the rate of major cardiovascular events among overweight or obese patients.
HbA1c levels following left ventricular assist device implantation were statistically significantly lower than before surgery.
Investigators analyze characteristics of participants with acquired partial lipodystrophy who developed severe metabolic abnormalities.
Genetic testing should become the standard of care for patients with definite or probable familial hypercholesterolemia.
Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.
Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes.
A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.
Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.
Excess cardiovascular risk varies with age at diagnosis of type 1 diabetes.
Low-density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) ≥160 mg/dL are independently associated with increased relative risk of cardiovascular disease (CVD) mortality in a low-risk cohort.
"We are extremely disappointed with the FDA's decision. We continue to feel strongly that Waylivra demonstrates a favorable benefit/risk profile in people with FCS," said Akcea CEO, Paula Soteropoulos.
Up-titration to a high-intensity statin occurred in only 37.7% of patients with diabetes after an acute myocardial infarction.
The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.
While antipsychotic treatments can improve behavioral symptoms, risk of hyperglycemia and weight gain should inform careful consideration of antipsychotic use in young patients.
Investigators assessed the effect of exercise modality during dietary-induced on bone health.
Serum 25-hydroxyvitamin D [25(OH)D] is independently and inversely associated with total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol in children.
Nutraceuticals may offer a solution to patients who cannot tolerate statins because of severe muscle pain.
Higher body mass index is likely to cause worse cardiovascular health in youth.
Investigators sought to determine the frequency of metabolic syndrome in patients with nonfunctioning adrenal incidentalomas.
Compliance with general population guidelines for diabetes screening was suboptimal among patients with rheumatoid arthritis.
High total HDL cholesterol in postmenopausal women may mask heart disease risk.
High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents
The association between albumin-to-creatinine ratio and risk for diabetic nephropathy and CVD was examined over 2 to 4 years.
Investigators examine the association between various skin conditions and metabolic syndrome.
Researchers assessed whether adding or switching to sulfonylureas is linked to increased risk for myocardial infarction, ischemic stroke, hypoglycemia, and all-cause mortality.
There has been a substantial increase in the percentage of patients with high cholesterol over age 60 years taking lipid-lowering medications from 2005 to 2016, but such increases have not been seen among younger patients with high cholesterol.
High BMI, low physical activity levels, and frequent smoking and high genetic risk increased the risk for atrial fibrillation, coronary artery disease, hypertension, stroke, and diabetes.
African American patients were less likely than white patients to be treated with any statin and at the guideline-recommended intensity.
Investigators examined gender differences in baseline characteristics and outcomes in patients with t2d and ASCVD.
The relationship between circadian rhythm and sleep measures and components of metabolic syndrome in patients with bipolar disorder.
Older adults with metabolic syndrome experienced higher rates of depressive symptoms compared with older adults without metabolic syndrome.
Investigators revised pooled cohort equations to improve clinical accuracy to predict risk for cardiovascular disease.
Investigators examine the effects of the PCSK9 inhibitor alirocumab in patients with recent acute coronary syndrome and diabetes.
Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.
Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.
Patients with remitted bipolar disorder and emotional hyper-reactivity also have significantly higher levels of low-grade inflammation, hypertension, and impaired glucose metabolism, indicating a higher risk for cardiometabolic dysfunction.
Regardless of presence of preexisting cardiovascular disease, SGLT2 inhibitors were associated with lower risk for death and heart failure.
These results support the need to assess the role of sleep quantity and quality interventions as strategies for improving cardiovascular risk profiles of adolescents.
To understand the mechanism underlying the benefit of fenofibrate on vascular complications in patients with type 2 diabetes, investigators assessed carotid intima thickness as a marker of subclinical atherosclerosis.
Researchers assessed the effect of testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin levels on coronary heart disease, heart failure, and cardiovascular disease in postmenopausal women.
The United States Preventive Services Task Force does not recommend screening with resting or exercise electrocardiography in asymptomatic individuals at low risk for cardiovascular disease events.
Investigators sought to determine whether serum lipid levels were associated with depression in patients with psychotic disorders.
Investigators sought to assess the link between treatment for thyroid cancer and subsequent cardiac and vascular complications.
Regardless of long-term metabolic health maintenance, obesity remains a risk factor for cardiovascular disease.
Investigators examined the effect of progestin-only contraceptive on cardiometabolic outcomes, including stroke, MI, hypertension, diabetes, and VTE.
For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.
Fewer Major Adverse Cardiovascular Events With New Antihyperglycemic Drugs With Lower Hypoglycemic Risk
Investigators proposed that reduction in MACE may be proportional to the magnitude of HbA1c reduction seen with newer antihyperglycemic agents.
Researchers found that metabolic syndrome was associated with lower neurocognitive function, particularly among middle-aged adults.
The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).
Researchers investigated effects of eplerenone on insulin sensitivity, inflammatory indices, and other metabolic parameters in HIV.
Younger patients treated with antipsychotics after experiencing a first episode of psychosis are at an increased risk for metabolic syndrome and cardiovascular disease.
Researchers used multiparametric cardiovascular magnetic resonance imaging to examine the correlation between aortic stiffness and LV geometry in younger adults with type 2 diabetes.
Endocrinology Advisor Articles
- Testosterone Use Remains High Among Men With Coronary Artery Disease
- Insulin Analogs vs Regular Human Insulin for Type 2 Diabetes
- Primary Characteristics of PCOS Predictive of Obstetric Complications
- Trends in Bisphosphonate Use and Hip Fracture Rates in Denmark
- Maternal Thyroid Function in Pregnancy Linked to Childhood Risk for Disease
- ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care
- Sleep Habits Affect Insulin Sensitivity in Adolescents With Overweight, Obesity
- Levothyroxine Associated With Increased Mortality in Patients With Heart Failure
- Head-to-Head Comparison of Professional vs Personal CGM Systems in T1D
- Dual vs Triple Therapy for Metformin Treatment Intensification in Type 2 Diabetes
- Risk for Congenital Heart Defects in Offspring of Mothers With Obesity
- Is the MiniMed 670G System Safe for Children With Type 1 Diabetes?
- Gender-Affirming Hormonal Treatment and Long-Term Bone Safety
- Obesity Linked to Lower Gray Matter Brain Volume
- No Evidence for Health Benefits of Nonsugar Sweeteners