Cardiovascular and Metabolic Disorders Archive

Simvastatin Improves Inflammation, Platelet Activation Markers in Primary Hypercholesterolemia

Simvastatin Improves Inflammation, Platelet Activation Markers in Primary Hypercholesterolemia

In patients with primary hypercholesterolemia, short-term treatment with simvastatin improved the lipid profile and exerted a beneficial effect on a wide range of proatherogenic and prothrombotic parameters.

Alirocumab Well Tolerated and Effective in Patients With Statin Intolerance

Alirocumab Well Tolerated and Effective in Patients With Statin Intolerance

Researcher observed a much lower rate of discontinuations due to skeletal muscle events with alirocumab in the open-label extension trial compared with the double-blind parent study (3.2% vs 15.9%).

Consensus Guidelines Reinforce Healthy Living for Lowering Cholesterol

Consensus Guidelines Reinforce Healthy Living for Lowering Cholesterol

A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course.

Icosapent Ethyl Reduces Ischemic Event Risk in Patients With Hypertriglyceridemia Despite Statin Use

Icosapent Ethyl Reduces Ischemic Event Risk in Patients With Hypertriglyceridemia Despite Statin Use

The risk for the primary composite endpoint was significantly lowered by 25% among patients who received 2g of icosapent ethyl twice daily vs those who received placebo.

Long-Term Evolocumab Safe and Effective for Treating Hypercholesterolemia

Long-Term Evolocumab Safe and Effective for Treating Hypercholesterolemia

Evolocumab consistently reduced LDL-C with no increase in adverse events over a 5-year study period.

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Treatment Examined

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Treatment Examined

The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.

Nonadherence, Discontinuation High in First Year of Statin Therapy

Nonadherence, Discontinuation High in First Year of Statin Therapy

First-year nonadherence and discontinuation are high among older adults prescribed statins.

Cardiometabolic Disease Patterns Related to Race, Ethnicity in Midlife Women

Cardiometabolic Disease Patterns Related to Race, Ethnicity in Midlife Women

Women entering menopause had patterns of cardiometabolic risk components related to race/ethnicity.

Lipidome Profiles Stratify Risk for Type 2 Diabetes

Lipidome Profiles Stratify Risk for Type 2 Diabetes

Early detection of lipidome characteristics could help identify the early onset of type 2 diabetes.

Another Antihypertensive Recalled Due to Potentially Carcinogenic Impurity

Another Antihypertensive Recalled Due to Potentially Carcinogenic Impurity

The impurity was identified following laboratory testing conducted by the Food and Drug Administration (FDA); this is the first non-valsartan product that the Agency has found to contain NDEA.

Statin-Induced Myalgia Unrelated to Muscle Coenzyme Q10 Level

Statin-Induced Myalgia Unrelated to Muscle Coenzyme Q10 Level

Statin therapy is associated with reduced mitochondrial complex II-linked respiration, and statin-induced myalgia is coupled to an increased intrinsic mitochondrial respiratory function, while intramuscular [coenzyme Q10] levels are unaltered.

Lack of Evidence for Noncardiovascular Outcomes With Statin Use

Lack of Evidence for Noncardiovascular Outcomes With Statin Use

There is a lack of convincing evidence for an association between statin use and noncardiovascular disease outcomes.

Diet and Physical Activity Factors in Metabolic Syndrome With Depression

Diet and Physical Activity Factors in Metabolic Syndrome With Depression

Investigators examine the association between depression and metabolic syndrome, factoring in diet and physical activity.

Therapeutic Lifestyle Intervention in Church Helpful for Reducing Systolic BP

Therapeutic Lifestyle Intervention in Church Helpful for Reducing Systolic BP

A therapeutic lifestyle change (TLC) intervention plus motivational interviewing (MINT) sessions delivered in churches can reduce systolic blood pressure (BP) among blacks compared with health education (HE) alone.

Canagliflozin Approved to Reduce Risk for Cardiovascular Events in T2D

Canagliflozin Approved to Reduce Risk for Cardiovascular Events in T2D

The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.

Type 2 Diabetes an Independent Risk Factor for Coronary Artery Disease

Type 2 Diabetes an Independent Risk Factor for Coronary Artery Disease

Type 2 diabetes is an independent risk factor for sudden cardiac arrest and death in patients with coronary artery disease with preserved ejection fraction.

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia lead levels are associated with resistant-hypertension.

Saxenda Labeling Updated With Cardiovascular Safety Data

Saxenda Labeling Updated With Cardiovascular Safety Data

The randomized, double-blind, placebo-controlled, parallel-group study (N = 9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.

Oral Health Linked to Blood Pressure Profile, Treatment Success During Antihypertensive Therapy

Oral Health Linked to Blood Pressure Profile, Treatment Success During Antihypertensive Therapy

For adults with treated hypertension, periodontitis is associated with higher mean systolic blood pressure and with increased odds of unsuccessful hypertensive treatment.

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.

Bariatric Surgery Reduces Macrovascular Complications in Obesity, T2D

Bariatric Surgery Reduces Macrovascular Complications in Obesity, T2D

For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery.

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

Supplementation with coenzyme Q10 may be an effective approach for managing statin-induced myopathy.

Cardiovascular Disease Risk Persists Years After Treatment of Thyrotoxicosis

Cardiovascular Disease Risk Persists Years After Treatment of Thyrotoxicosis

Excess cardiovascular disease mortality persisted for many years after thyroid-ablative treatment in patients who received radioactive iodine who did not become hypothyroid.

Sexual Harassment, Assault Tied to Women's Health Issues

Sexual Harassment, Assault Tied to Women's Health Issues

Sexual harassment and sexual assault among midlife women are associated with poorer physical and mental health.

Shared Financial Incentives Cost-Effective for Controlling LDL-C Levels

Shared Financial Incentives Cost-Effective for Controlling LDL-C Levels

Implementing shared financial incentives between physicians and patients is a cost-effective intervention strategy for controlling LDL-C levels among high-risk patients.

Lorcaserin Facilitates Weight Loss in Patients Who Are Overweight, Obese

Lorcaserin Facilitates Weight Loss in Patients Who Are Overweight, Obese

Lorcaserin facilitates sustained weight loss without increasing the rate of major cardiovascular events among overweight or obese patients.

LVAD in Heart Failure Linked to Improved Glycemic Control

LVAD in Heart Failure Linked to Improved Glycemic Control

HbA1c levels following left ventricular assist device implantation were statistically significantly lower than before surgery.

Characteristics of Acquired Partial Lipodystrophy With Metabolic Abnormalities

Characteristics of Acquired Partial Lipodystrophy With Metabolic Abnormalities

Investigators analyze characteristics of participants with acquired partial lipodystrophy who developed severe metabolic abnormalities.

Genetic Testing Recommended for Familial Hypercholesterolemia

Genetic Testing Recommended for Familial Hypercholesterolemia

Genetic testing should become the standard of care for patients with definite or probable familial hypercholesterolemia.

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.

Widespread Statin Use Not Recommended in Old, Very Old

Widespread Statin Use Not Recommended in Old, Very Old

Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

Trends in Cardiovascular Deaths for US Adults With and Without Diabetes

Trends in Cardiovascular Deaths for US Adults With and Without Diabetes

Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.

Excess Cardiac Risk Varies With Age of Onset of Type 1 Diabetes

Excess Cardiac Risk Varies With Age of Onset of Type 1 Diabetes

Excess cardiovascular risk varies with age at diagnosis of type 1 diabetes.

High LDL in Young, Healthy Adults Leaves Them Vulnerable to CVD

High LDL in Young, Healthy Adults Leaves Them Vulnerable to CVD

Low-density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) ≥160 mg/dL are independently associated with increased relative risk of cardiovascular disease (CVD) mortality in a low-risk cohort.

Akcea and Ionis Receive Complete Response Letter for WAYLIVRA from FDA

Akcea and Ionis Receive Complete Response Letter for WAYLIVRA from FDA

"We are extremely disappointed with the FDA's decision. We continue to feel strongly that Waylivra demonstrates a favorable benefit/risk profile in people with FCS," said Akcea CEO, Paula Soteropoulos.

Low Rates of Increasing Statin Doses After MI in Diabetes

Low Rates of Increasing Statin Doses After MI in Diabetes

Up-titration to a high-intensity statin occurred in only 37.7% of patients with diabetes after an acute myocardial infarction.

Assessing the Evidence of Aspirin for Primary Prevention in Diabetes

Assessing the Evidence of Aspirin for Primary Prevention in Diabetes

The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.

Antipsychotics Adversely Affect Adiposity and Insulin Sensitivity in Youths

Antipsychotics Adversely Affect Adiposity and Insulin Sensitivity in Youths

While antipsychotic treatments can improve behavioral symptoms, risk of hyperglycemia and weight gain should inform careful consideration of antipsychotic use in young patients.

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Investigators assessed the effect of exercise modality during dietary-induced on bone health.

Vitamin D Independently, Inversely Tied to Total, HDL, LDL Cholesterol in Children

Vitamin D Independently, Inversely Tied to Total, HDL, LDL Cholesterol in Children

Serum 25-hydroxyvitamin D [25(OH)D] is independently and inversely associated with total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol in children.

Nutraceuticals May Benefit Patients Who Are Statin Intolerant

Nutraceuticals May Benefit Patients Who Are Statin Intolerant

Nutraceuticals may offer a solution to patients who cannot tolerate statins because of severe muscle pain.

In Teens, Young Adults, High BMI May Hurt Cardiovascular Health

In Teens, Young Adults, High BMI May Hurt Cardiovascular Health

Higher body mass index is likely to cause worse cardiovascular health in youth.

Nonfunctioning Adrenal Incidentaloma Associated With Metabolic Syndrome

Nonfunctioning Adrenal Incidentaloma Associated With Metabolic Syndrome

Investigators sought to determine the frequency of metabolic syndrome in patients with nonfunctioning adrenal incidentalomas.

Diabetes Screening Rates Suboptimal Among Patients With Rheumatoid Arthritis

Diabetes Screening Rates Suboptimal Among Patients With Rheumatoid Arthritis

Compliance with general population guidelines for diabetes screening was suboptimal among patients with rheumatoid arthritis.

'Good' Cholesterol May Not Be Good in Postmenopausal Women

'Good' Cholesterol May Not Be Good in Postmenopausal Women

High total HDL cholesterol in postmenopausal women may mask heart disease risk.

High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents

High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents

The association between albumin-to-creatinine ratio and risk for diabetic nephropathy and CVD was examined over 2 to 4 years.

The Association Between Skin Diseases and Metabolic Syndrome

The Association Between Skin Diseases and Metabolic Syndrome

Investigators examine the association between various skin conditions and metabolic syndrome.

Second-Line Sulfonylurea Therapy Linked to Cardiovascular Events in Type 2 Diabetes

Second-Line Sulfonylurea Therapy Linked to Cardiovascular Events in Type 2 Diabetes

Researchers assessed whether adding or switching to sulfonylureas is linked to increased risk for myocardial infarction, ischemic stroke, hypoglycemia, and all-cause mortality.

CDC: More People With High Cholesterol Taking Medications

CDC: More People With High Cholesterol Taking Medications

There has been a substantial increase in the percentage of patients with high cholesterol over age 60 years taking lipid-lowering medications from 2005 to 2016, but such increases have not been seen among younger patients with high cholesterol.

CVD Risk Independently Predicted by Poor Lifestyle Factors

CVD Risk Independently Predicted by Poor Lifestyle Factors

High BMI, low physical activity levels, and frequent smoking and high genetic risk increased the risk for atrial fibrillation, coronary artery disease, hypertension, stroke, and diabetes.

Statin Use and Cardiovascular Risk Perception Varies Among Races

Statin Use and Cardiovascular Risk Perception Varies Among Races

African American patients were less likely than white patients to be treated with any statin and at the guideline-recommended intensity.

Cardiovascular Disease Risk Lower in Women With Type 2 Diabetes

Cardiovascular Disease Risk Lower in Women With Type 2 Diabetes

Investigators examined gender differences in baseline characteristics and outcomes in patients with t2d and ASCVD.

Improving Sleep Quality May Reduce Cardiovascular Risk in Bipolar Disorder

Improving Sleep Quality May Reduce Cardiovascular Risk in Bipolar Disorder

The relationship between circadian rhythm and sleep measures and components of metabolic syndrome in patients with bipolar disorder.

Depression May Be Associated With Metabolic Syndrome in Older Adults

Depression May Be Associated With Metabolic Syndrome in Older Adults

Older adults with metabolic syndrome experienced higher rates of depressive symptoms compared with older adults without metabolic syndrome.

Revised Pooled Cohort Equations for CVD Risk Improve Accuracy of Estimates

Revised Pooled Cohort Equations for CVD Risk Improve Accuracy of Estimates

Investigators revised pooled cohort equations to improve clinical accuracy to predict risk for cardiovascular disease.

Cardiovascular Outcomes in Patients With ACS, Diabetes Using Alirocumab

Cardiovascular Outcomes in Patients With ACS, Diabetes Using Alirocumab

Investigators examine the effects of the PCSK9 inhibitor alirocumab in patients with recent acute coronary syndrome and diabetes.

Metabolic Health Predicative of Cognitive Development in Children

Metabolic Health Predicative of Cognitive Development in Children

Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.

Elevated Triglycerides, Diabetes May Be Predictors of Major Cardiovascular Events

Elevated Triglycerides, Diabetes May Be Predictors of Major Cardiovascular Events

Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.

Emotional Hyper-Reactivity and Cardiometabolic Risk in Remitted Bipolar Disorder

Emotional Hyper-Reactivity and Cardiometabolic Risk in Remitted Bipolar Disorder

Patients with remitted bipolar disorder and emotional hyper-reactivity also have significantly higher levels of low-grade inflammation, hypertension, and impaired glucose metabolism, indicating a higher risk for cardiometabolic dysfunction.

SGLT2 Inhibitor Use Linked to Lower Risk for Heart Failure, Death in Type 2 Diabetes

SGLT2 Inhibitor Use Linked to Lower Risk for Heart Failure, Death in Type 2 Diabetes

Regardless of presence of preexisting cardiovascular disease, SGLT2 inhibitors were associated with lower risk for death and heart failure.

Good Sleep Tied to Better Cardiometabolic Health in Youths

Good Sleep Tied to Better Cardiometabolic Health in Youths

These results support the need to assess the role of sleep quantity and quality interventions as strategies for improving cardiovascular risk profiles of adolescents.

Fenofibrate Improves Cholesterol Levels in Type 2 Diabetes

Fenofibrate Improves Cholesterol Levels in Type 2 Diabetes

To understand the mechanism underlying the benefit of fenofibrate on vascular complications in patients with type 2 diabetes, investigators assessed carotid intima thickness as a marker of subclinical atherosclerosis.

Sex Hormone Levels May Affect Postmenopausal Heart Disease Risk

Sex Hormone Levels May Affect Postmenopausal Heart Disease Risk

Researchers assessed the effect of testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin levels on coronary heart disease, heart failure, and cardiovascular disease in postmenopausal women.

USPSTF Does Not Recommend Electrocardiography Screening in Low-Risk CVD

USPSTF Does Not Recommend Electrocardiography Screening in Low-Risk CVD

The United States Preventive Services Task Force does not recommend screening with resting or exercise electrocardiography in asymptomatic individuals at low risk for cardiovascular disease events.

Depression, C-Reactive Protein, and Osteoprotegerin May Affect Dyslipidemia

Depression, C-Reactive Protein, and Osteoprotegerin May Affect Dyslipidemia

Investigators sought to determine whether serum lipid levels were associated with depression in patients with psychotic disorders.

Thyroid Cancer Survivors at Higher Risk for Cardiovascular Disease

Thyroid Cancer Survivors at Higher Risk for Cardiovascular Disease

Investigators sought to assess the link between treatment for thyroid cancer and subsequent cardiac and vascular complications.

Metabolic Health Maintenance Key to Preventing Cardiovascular Disease

Metabolic Health Maintenance Key to Preventing Cardiovascular Disease

Regardless of long-term metabolic health maintenance, obesity remains a risk factor for cardiovascular disease.

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

Injectable Progestin-Only Contraceptives May Increase Risk for VTE

Investigators examined the effect of progestin-only contraceptive on cardiometabolic outcomes, including stroke, MI, hypertension, diabetes, and VTE.

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.

Fewer Major Adverse Cardiovascular Events With New Antihyperglycemic Drugs With Lower Hypoglycemic Risk

Fewer Major Adverse Cardiovascular Events With New Antihyperglycemic Drugs With Lower Hypoglycemic Risk

Investigators proposed that reduction in MACE may be proportional to the magnitude of HbA1c reduction seen with newer antihyperglycemic agents.

Metabolic Syndrome Linked to Reduced Neurocognitive Function in Midlife

Metabolic Syndrome Linked to Reduced Neurocognitive Function in Midlife

Researchers found that metabolic syndrome was associated with lower neurocognitive function, particularly among middle-aged adults.

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).

Eplerenone May Improve Cardiovascular Disease Risk in HIV

Eplerenone May Improve Cardiovascular Disease Risk in HIV

Researchers investigated effects of eplerenone on insulin sensitivity, inflammatory indices, and other metabolic parameters in HIV.

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

Younger patients treated with antipsychotics after experiencing a first episode of psychosis are at an increased risk for metabolic syndrome and cardiovascular disease.

Aortic Stiffness, Concentric LV Remodeling Linked in Type 2 Diabetes

Aortic Stiffness, Concentric LV Remodeling Linked in Type 2 Diabetes

Researchers used multiparametric cardiovascular magnetic resonance imaging to examine the correlation between aortic stiffness and LV geometry in younger adults with type 2 diabetes.

In LVSD, Diabetes Tied to Higher Risk of Heart Failure

In LVSD, Diabetes Tied to Higher Risk of Heart Failure

In patients with asymptomatic left ventricular systolic dysfunction, diabetes is associated with an increased risk of developing heart failure.

Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus

Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus

The frequency of metabolic syndrome among patients with SLE was approximately 45%.

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Using both public and private health insurance claims data, investigators conducted a retrospective cohort study to assess cardiovascular risk in the setting of diabetes and rheumatoid arthritis.

Metabolic Syndrome Associated With Higher ALT Levels in Chronic Hepatitis B

Metabolic Syndrome Associated With Higher ALT Levels in Chronic Hepatitis B

Findings highlight the importance of screening for metabolic syndrome (MS) and the potential for MS to influence alanine aminotransferase and its interpretation in the context of HBV treatment decisions.

Young Adults With Type 1 Diabetes Show Muscle Metabolic Deficiencies

Young Adults With Type 1 Diabetes Show Muscle Metabolic Deficiencies

Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle.

Increased Risk for Mortality in People With Diabetes, CHD Taking Beta-Blockers

Increased Risk for Mortality in People With Diabetes, CHD Taking Beta-Blockers

Further studies are needed to assess whether beta-blockers are effective in reducing mortality and coronary events in patients with diabetes receiving optimal medical treatment.

Sacubitril/Valsartan May Help Preserve Kidney Function in Patients With HFrEF

Sacubitril/Valsartan May Help Preserve Kidney Function in Patients With HFrEF

Compared with the enalapril-treated group, those treated with sacubitril/valsartan were found to have significantly slower kidney decline.

Soluble Klotho Levels Predictive of Kidney Failure in Type 2 Diabetes

Soluble Klotho Levels Predictive of Kidney Failure in Type 2 Diabetes

In patients with type 2 diabetes and with relatively preserved estimated glomerular filtration rate, reduced levels of soluble Klotho predict renal function decline independent of traditional risk markers.

ADA Updates Guidelines for Cardiovascular Risk Management in Diabetes

ADA Updates Guidelines for Cardiovascular Risk Management in Diabetes

The American Diabetes Association has updated its Clinical Standards of Medical Care guidelines for identifying and managing cardiovascular risk factors in diabetes.

FT3 Level Associated With the Development of Metabolic Syndrome

FT3 Level Associated With the Development of Metabolic Syndrome

Researchers designed a cohort study to examine whether serum thyroid hormone levels within the reference range are predictive factors for developing metabolic syndrome in adults.

Canagliflozin May Improve Renal Outcomes in Patients With Type 2 Diabetes

Canagliflozin May Improve Renal Outcomes in Patients With Type 2 Diabetes

The renal protective benefit was seen in patients with both reduced (eGFR <60mL/min/1.73m2) and preserved (eGFR ≥60mL/min/1.73m2) renal function.

Menopause Symptom Severity May Predict Heart Disease

Menopause Symptom Severity May Predict Heart Disease

Researchers examined whether menopausal symptoms, quality of life, and depression are related to arterial stiffness, a risk factor for cardiovascular disease.

Eating Pecans May Cut Risk for Cardiovascular Disease, Diabetes

Eating Pecans May Cut Risk for Cardiovascular Disease, Diabetes

Changes in serum insulin and homeostatic model assessment of insulin resistance and beta cell function were significantly greater compared to the control diet

BMI As Predictor of CVD Risk May Be More Susceptible to Bias

BMI As Predictor of CVD Risk May Be More Susceptible to Bias

The J-shaped correlation seen for body mass index with cardiovascular disease risk is susceptible to confounding due to pre-existing comorbidities.

Noninvasive CAD Screening May Reduce Cardiac Events in Individuals With Asymptomatic Diabetes

Noninvasive CAD Screening May Reduce Cardiac Events in Individuals With Asymptomatic Diabetes

Compared with standard care, noninvasive coronary artery disease screening reduced cardiac events by 27% in individuals with asymptomatic diabetes. Results justify larger, appropriately powered trials to potentially revisit current recommendations.

Risk for Cardiovascular Disease Higher in Survivors of Testicular Cancer

Risk for Cardiovascular Disease Higher in Survivors of Testicular Cancer

Results from the ongoing Platinum Study revealed the prevalence of risk factors for CVD among survivors of testicular cancer who received chemotherapy for their cancer.

Risk Factors for Cardiovascular Disease in Youth With Type 1 Diabetes

Risk Factors for Cardiovascular Disease in Youth With Type 1 Diabetes

Early treatment of cardiovascular disease risk factors such as dyslipidemia and hypertension will have long-term benefits with low risk and cost and should be more widely used in pediatric type 1 diabetes care.

Only Half of Adults With Familial Hypercholesterolemia on Statins

Only Half of Adults With Familial Hypercholesterolemia on Statins

Only about 50% of adults with familial hypercholesterolemia are on statin therapy, and approximately 30% of those are taking high-intensity statins.

Change in BMI During Puberty Tied to Later Heart Failure Risk in Men

Change in BMI During Puberty Tied to Later Heart Failure Risk in Men

Change in body mass index to overweight during puberty significantly increases men's risk of heart failure later in life.

Negative Symptoms Increase Cardiovascular Risk in Schizophrenia

Negative Symptoms Increase Cardiovascular Risk in Schizophrenia

Although various clinical and psychosocial factors were associated with unhealthy lifestyle factors and higher risk for CVD, the strongest associations were with negative symptoms.

Cardiovascular Outcomes of SGLT-2i vs Other Glucose-Lowering Drugs in T2D

Cardiovascular Outcomes of SGLT-2i vs Other Glucose-Lowering Drugs in T2D

A recent study evaluated the effects of SGLT-2i and other glucose-lowering drugs on cardiovascular event outcomes in patients with type 2 diabetes from 6 countries in 3 world regions.

Canakinumab Does Not Appear to Prevent Diabetes Onset

Canakinumab Does Not Appear to Prevent Diabetes Onset

The new analysis focuses on the remaining 4960 patients, who had prediabetes at the start of the trial.

Effect of Menopausal Hormone Therapy on Cardiac Structure, Function

Effect of Menopausal Hormone Therapy on Cardiac Structure, Function

Researchers examined the effect of menopausal hormone therapy on left ventricular and left atrial chamber structure and function changes, which are markers of subclinical cardiovascular disease.

Tresiba Label Updated With Data on Severe Hypoglycemia, CV Outcomes

Tresiba Label Updated With Data on Severe Hypoglycemia, CV Outcomes

The Tresiba label was updated to reflect safety outcomes from the DEVOTE trial.

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