Insulin Resistance Higher With Long-Term Exposure to Air Pollution

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Long-term exposure to air pollution is associated with insulin resistance.
Long-term exposure to air pollution is associated with insulin resistance.

HealthDay News -- Long-term exposure to air pollution is associated with insulin resistance among the general population, according to a study published online September 7 in Diabetes.

Kathrin Wolf, PhD, from the Institute of Epidemiology in Neuherberg, Germany, and colleagues examined the correlation between long-term exposure to air pollution at residence and biomarkers related to insulin resistance, subclinical inflammation, and adipokines. Data were included for 2944 participants of the study.

The researchers found that a 7.9 µg/m³ increment in particulate matter <10 µm correlated with higher homeostatic model assessment of insulin resistance (HOMA-IR) and insulin among all participants. There were correlations for nitrogen dioxide with HOMA-IR, glucose, insulin, and leptin. For individuals with prediabetes, the effect estimates were much larger and highly significant, while weak associations were seen for those without diabetes and with diabetes. There was no correlation seen for glycated hemoglobin.

"Our results suggested an association between long-term exposure to air pollution and insulin resistance in the general population mainly attributable to prediabetic individuals," the researchers wrote.

Reference

  1. Wolf K, Popp A, Schneider A, et al; for the KORA-Study Group. Association between long-term exposure to air pollution and biomarkers related to insulin resistance, subclinical inflammation and adipokines. Diabetes. 2016. doi:10.2337/db15-1567.
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