Cardiovascular & Metabolic Disorders

Long-Term Evolocumab Safe and Effective for Treating Hypercholesterolemia

Long-Term Evolocumab Safe and Effective for Treating Hypercholesterolemia

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Evolocumab consistently reduced LDL-C with no increase in adverse events over a 5-year study period.

Nonadherence, Discontinuation High in First Year of Statin Therapy

Nonadherence, Discontinuation High in First Year of Statin Therapy

First-year nonadherence and discontinuation are high among older adults prescribed statins.

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Treatment Examined

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Treatment Examined

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The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.

Cardiometabolic Disease Patterns Related to Race, Ethnicity in Midlife Women

Cardiometabolic Disease Patterns Related to Race, Ethnicity in Midlife Women

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Women entering menopause had patterns of cardiometabolic risk components related to race/ethnicity.

Lipidome Profiles Stratify Risk for Type 2 Diabetes

Lipidome Profiles Stratify Risk for Type 2 Diabetes

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Early detection of lipidome characteristics could help identify the early onset of type 2 diabetes.

Skin Disease and Metabolic Syndrome: Early Warning Signs of a Greater Problem

Skin Disease and Metabolic Syndrome: Early Warning Signs of a Greater Problem

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Skin disorders, particularly those with known inflammatory mechanisms, may be considered potential early markers for the development of insulin resistance leading to metabolic syndrome, type 2 diabetes, and cardiovascular disease.

Lack of Evidence for Noncardiovascular Outcomes With Statin Use

Lack of Evidence for Noncardiovascular Outcomes With Statin Use

There is a lack of convincing evidence for an association between statin use and noncardiovascular disease outcomes.

Statin-Induced Myalgia Unrelated to Muscle Coenzyme Q10 Level

Statin-Induced Myalgia Unrelated to Muscle Coenzyme Q10 Level

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Statin therapy is associated with reduced mitochondrial complex II-linked respiration, and statin-induced myalgia is coupled to an increased intrinsic mitochondrial respiratory function, while intramuscular [coenzyme Q10] levels are unaltered.

Diet and Physical Activity Factors in Metabolic Syndrome With Depression

Diet and Physical Activity Factors in Metabolic Syndrome With Depression

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Investigators examine the association between depression and metabolic syndrome, factoring in diet and physical activity.

Therapeutic Lifestyle Intervention in Church Helpful for Reducing Systolic BP

Therapeutic Lifestyle Intervention in Church Helpful for Reducing Systolic BP

A therapeutic lifestyle change (TLC) intervention plus motivational interviewing (MINT) sessions delivered in churches can reduce systolic blood pressure (BP) among blacks compared with health education (HE) alone.

Canagliflozin Approved to Reduce Risk for Cardiovascular Events in T2D

Canagliflozin Approved to Reduce Risk for Cardiovascular Events in T2D

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The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia lead levels are associated with resistant-hypertension.

Type 2 Diabetes an Independent Risk Factor for Coronary Artery Disease

Type 2 Diabetes an Independent Risk Factor for Coronary Artery Disease

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Type 2 diabetes is an independent risk factor for sudden cardiac arrest and death in patients with coronary artery disease with preserved ejection fraction.

Oral Health Linked to Blood Pressure Profile, Treatment Success During Antihypertensive Therapy

Oral Health Linked to Blood Pressure Profile, Treatment Success During Antihypertensive Therapy

For adults with treated hypertension, periodontitis is associated with higher mean systolic blood pressure and with increased odds of unsuccessful hypertensive treatment.

Saxenda Labeling Updated With Cardiovascular Safety Data

Saxenda Labeling Updated With Cardiovascular Safety Data

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The randomized, double-blind, placebo-controlled, parallel-group study (N = 9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

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Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.

Bariatric Surgery Reduces Macrovascular Complications in Obesity, T2D

Bariatric Surgery Reduces Macrovascular Complications in Obesity, T2D

For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery.

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

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Supplementation with coenzyme Q10 may be an effective approach for managing statin-induced myopathy.

Cardiovascular Disease Risk Persists Years After Treatment of Thyrotoxicosis

Cardiovascular Disease Risk Persists Years After Treatment of Thyrotoxicosis

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Excess cardiovascular disease mortality persisted for many years after thyroid-ablative treatment in patients who received radioactive iodine who did not become hypothyroid.

Shared Financial Incentives Cost-Effective for Controlling LDL-C Levels

Shared Financial Incentives Cost-Effective for Controlling LDL-C Levels

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Implementing shared financial incentives between physicians and patients is a cost-effective intervention strategy for controlling LDL-C levels among high-risk patients.

Lorcaserin Facilitates Weight Loss in Patients Who Are Overweight, Obese

Lorcaserin Facilitates Weight Loss in Patients Who Are Overweight, Obese

Lorcaserin facilitates sustained weight loss without increasing the rate of major cardiovascular events among overweight or obese patients.

Investigating the Link Between Atrial Fibrillation and Type 2 Diabetes

Investigating the Link Between Atrial Fibrillation and Type 2 Diabetes

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Compared with the general population, patients with type 2 diabetes are at a 35% to 60% greater risk for atrial fibrillation.

LVAD in Heart Failure Linked to Improved Glycemic Control

LVAD in Heart Failure Linked to Improved Glycemic Control

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HbA1c levels following left ventricular assist device implantation were statistically significantly lower than before surgery.

Genetic Testing Recommended for Familial Hypercholesterolemia

Genetic Testing Recommended for Familial Hypercholesterolemia

Genetic testing should become the standard of care for patients with definite or probable familial hypercholesterolemia.

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.

Widespread Statin Use Not Recommended in Old, Very Old

Widespread Statin Use Not Recommended in Old, Very Old

Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

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A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

Trends in Cardiovascular Deaths for US Adults With and Without Diabetes

Trends in Cardiovascular Deaths for US Adults With and Without Diabetes

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Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.

Low Rates of Increasing Statin Doses After MI in Diabetes

Low Rates of Increasing Statin Doses After MI in Diabetes

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Up-titration to a high-intensity statin occurred in only 37.7% of patients with diabetes after an acute myocardial infarction.

High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents

High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents

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The association between albumin-to-creatinine ratio and risk for diabetic nephropathy and CVD was examined over 2 to 4 years.

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