High-resolution peripheral quantitative computed tomography (HR-pQCT) indices improve prediction of fracture beyond bone mineral density and Fracture Risk Assessment Tool (FRAX) scores in older adults.
Statin use is associated with better cortical bone characteristics in older women with osteoporosis, but results are dependent upon the potency of the statins.
The use of lateral spine imaging to detect asymptomatic vertebral fractures in older women may improve osteoporosis identification.
There is a slight association between maternal gestational weight gain and offspring bone mineralization in under/normal weight women, but not in overweight/obese women.
Insulin resistance may play an intermediary role in the relationship between adiposity and lumbar spine bone mass in adolescents.
Tibia lead levels are associated with resistant-hypertension.
Children who are consistent sport participators have greater bone mineral content (BMC) at age 20 years.
There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.
A growing body of research highlights the important role of bone in glucose metabolism.
The risk for fragility fractures is significantly lower in women with osteopenia who receive zoledronate than in those who receive placebo.
Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.
Roux-en-Y gastric bypass is associated with bone density and skeletal microarchitecture deterioration, leading to substantial cumulative bone loss.
Glucocorticoid therapy was linked to significant bone deficits across multiple axial sites, regardless of disease activity.
MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of FractureOctober 01, 2018
Findings suggest potential pathomechanistic links between miRNAs and cortical porosity. .
Investigators sought to determine the effects of vitamin D3 supplementation in postmenopausal women with low serum 25(OH)D and high parathyroid hormone levels.
Early life exposures, such as maternal smoking and breastfeeding, may have effects on bone mineral density in young adulthood.
Bisphosphonate holidays of 3 to 5 years have been recommended as a means of achieving the antifracture benefit of the medication.
Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.
Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.
Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.
Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.
Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.
Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.
Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.
A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.
Investigators compared biomarkers in patients who eventually developed radiographic osteolytic lesions to those who did not.
Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.
Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.
Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.
Screening with bone measurement is recommended for women. Younger women are at more risk.
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