Bone Metabolism

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

By

The USPSTF has released recommendations for vitamin D and calcium supplementation for the primary prevention of fractures in community-dwelling adults.

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

By

Crysvita is an antibody that blocks fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses active vitamin D production by the kidney.

More Adverse Events and Higher Costs for Patients With RA on High-Dose Glucocorticoids

More Adverse Events and Higher Costs for Patients With RA on High-Dose Glucocorticoids

Investigators assessed the association between the cumulative dose of oral glucocorticoid treatment and expense associated with adverse events in patients with rheumatoid arthritis.

Thiazide Diuretic Use May Reduce Risk for Bone Fracture

Thiazide Diuretic Use May Reduce Risk for Bone Fracture

By

Thiazide diuretic use may convey a decreased risk of fracture and as such, the protective effect of this class of medicine should be considered when prescribing thiazide diuretics in clinical practice.

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

By

Researchers sought to identify associations of female reproductive factors with incidence of total knee arthroplasty in osteoarthritis.

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

By

Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.

SSRIs Associated With Reduced Bone Mass Density in Older Patients

SSRIs Associated With Reduced Bone Mass Density in Older Patients

By

One reason selective serotonin reuptake inhibitors may affect the likelihood of osteoporosis is that the drug antagonizes the serotonin transporter, 5-HTT.

Bone Mineral Density Response Rates With Abaloparatide in Postmenopausal Women

Bone Mineral Density Response Rates With Abaloparatide in Postmenopausal Women

By

At the 43-month endpoint, a total of 60.7% (307/506) of the abaloparatide followed by alendronate group had ≥3% increase in bone mass at all 3 sites (P<0.0001) vs. 24% (121/505) of the placebo followed by alendronate group.

Glucocorticoid Use in COPD Does Not Increase Fracture Risk

Glucocorticoid Use in COPD Does Not Increase Fracture Risk

By

Intermittent use of high-dose glucocorticoids did not increase the risk for any, osteoporotic, hip, or clinically symptomatic vertebral fractures in patients with chronic obstructive pulmonary disease.

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

By

Researchers have determined that treatment for osteoporosis with teriparatide is associated with greater bone formation than treatment with zoledronic acid.

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

By

Researchers investigated the effects of growth hormone vs placebo, as well as the effects of sex steroid replacement therapy on bone mineral density in growth hormone-treated young adults with Prader-Willi syndrome who had attained adult height.

Vitamin D Associated With Improved Bone Health in Epilepsy

Vitamin D Associated With Improved Bone Health in Epilepsy

By

In this review, 2 independent investigators searched clinical trial databases for studies that evaluated the link between vitamin D supplements and bone health in adult patients with epilepsy.

Abatacept May Improve Femoral Neck Bone Mineral Density in Rheumatoid Arthritis

Abatacept May Improve Femoral Neck Bone Mineral Density in Rheumatoid Arthritis

By

Abatacept was superior at increasing bone mineral density in the femoral neck compared with other biologic disease-modifying antirheumatic drugs, and may offer good efficacy for improving BMD in rheumatoid arthritis.

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

By

Researchers showed that decreased L1 trabecular attenuation is associated with increased risk for future osteoporotic fractures in adult patients aged ≥65 years undergoing abdominopelvic CT scans for other indications.

COX-2 Inhibitors Plus Metformin Lower Joint Replacement Rates in Osteoarthritis With T2D

COX-2 Inhibitors Plus Metformin Lower Joint Replacement Rates in Osteoarthritis With T2D

By

Researchers compared the effects of combined metformin and COX-2 inhibitor therapy vs COX-2 therapy alone on joint replacement surgery rates.

Damaging Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture

Damaging Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture

By

Researchers observed detrimental effects of RYGB on bone turnover, mass, structure, and strength just 6 months postoperatively, and these effects persisted throughout the duration of the 12-month study.

Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis

Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis

By

The use of biologic disease-modifying antirheumatic drugs has no medium-term effect on the risk for spinal fractures among patients with ankylosing spondylitis.

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

By

Study assessed the effect of denosumab on bone mineral density and incident fractures in older adults with primary hyperparathyroidism who could not undergo or refused surgery.

BMD and Parathyroid Hormone Levels in Pseudohypoparathyroidism 1B

BMD and Parathyroid Hormone Levels in Pseudohypoparathyroidism 1B

By

Study showed that parathyroid hormone was a significant predictor of lumbar spine bone mineral density Z-score for pseudohypoparathyroidism 1B patients.

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

By

A lower bone mineral density in the lumbar spine, femoral neck, and hip is associated with an increased risk for intracranial aneurysm.

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

By

In postmenopausal women at high risk for fracture, treatment with romosozumab for 12 months, followed by alendronate, was associated with significantly fewer hip fractures than treatment with alendronate alone.

Systemic Corticosteroid Use May Increase Fracture Risk in Pediatric Asthma

Systemic Corticosteroid Use May Increase Fracture Risk in Pediatric Asthma

By

Increased odds of fractures in pediatric patients with asthma may be associated with systemic corticosteroid use, but not with inhaled corticosteroid use.

Trabecular Bone Morphology Changes May Predict Bone Strength in Girls

Trabecular Bone Morphology Changes May Predict Bone Strength in Girls

By

Study investigated the correlations between age and body composition with trabecular morphology in a cohort of healthy girls age 9 to 18.

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

By

A recent literature review and meta-analysis indicates that growth hormone therapy may reduce the risk for fracture in patients with osteoporosis.

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

By

New findings do not support routine vitamin D and calcium supplementation in community-dwelling older adults for lowering the incidence of osteoporosis-related fractures.

Prevention of Bone Mineral Density Loss Needed in Epilepsy

Prevention of Bone Mineral Density Loss Needed in Epilepsy

By

Researchers conducted a long-term follow-up study to determine whether BMD loss, osteoporosis, and fractures were successfully treated or prevented in an urban population of patients with epilepsy and reduced bone density.

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

By

Teriparatide is associated with a lower risk for new vertebral and clinical fractures compared with risedronate in post-menopausal women being treated for severe osteoporosis.

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

By

Bone mineral density was evaluated annually of the lumbar spine and femoral neck.

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

By

The association between alendronate use and nonvertebral fracture was strongest in patients who received high doses of glucocorticoid.

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Sign Up for Free e-Newsletters

CME Focus