Bone Metabolism

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Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

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Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

Study assessed the effect of denosumab on bone mineral density and incident fractures in older adults with primary hyperparathyroidism who could not undergo or refused surgery.

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

A lower bone mineral density in the lumbar spine, femoral neck, and hip is associated with an increased risk for intracranial aneurysm.

BMD and Parathyroid Hormone Levels in Pseudohypoparathyroidism 1B

BMD and Parathyroid Hormone Levels in Pseudohypoparathyroidism 1B

Study showed that parathyroid hormone was a significant predictor of lumbar spine bone mineral density Z-score for pseudohypoparathyroidism 1B patients.

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

In postmenopausal women at high risk for fracture, treatment with romosozumab for 12 months, followed by alendronate, was associated with significantly fewer hip fractures than treatment with alendronate alone.

Systemic Corticosteroid Use May Increase Fracture Risk in Pediatric Asthma

Systemic Corticosteroid Use May Increase Fracture Risk in Pediatric Asthma

Increased odds of fractures in pediatric patients with asthma may be associated with systemic corticosteroid use, but not with inhaled corticosteroid use.

Trabecular Bone Morphology Changes May Predict Bone Strength in Girls

Trabecular Bone Morphology Changes May Predict Bone Strength in Girls

Study investigated the correlations between age and body composition with trabecular morphology in a cohort of healthy girls age 9 to 18.

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

A recent literature review and meta-analysis indicates that growth hormone therapy may reduce the risk for fracture in patients with osteoporosis.

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

New findings do not support routine vitamin D and calcium supplementation in community-dwelling older adults for lowering the incidence of osteoporosis-related fractures.

Prevention of Bone Mineral Density Loss Needed in Epilepsy

Prevention of Bone Mineral Density Loss Needed in Epilepsy

Researchers conducted a long-term follow-up study to determine whether BMD loss, osteoporosis, and fractures were successfully treated or prevented in an urban population of patients with epilepsy and reduced bone density.

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide is associated with a lower risk for new vertebral and clinical fractures compared with risedronate in post-menopausal women being treated for severe osteoporosis.

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

Bone mineral density was evaluated annually of the lumbar spine and femoral neck.

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

The association between alendronate use and nonvertebral fracture was strongest in patients who received high doses of glucocorticoid.

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Higher Prevalence of Sarcopenic Obesity in Osteoarthritis Than Rheumatoid Arthritis

Higher Prevalence of Sarcopenic Obesity in Osteoarthritis Than Rheumatoid Arthritis

The prevalence of sarcopenia — particularly in combination with ostepenia — increases with age, and sarcopenic obesity may be underrecognized, despite its impact in patients with rheumatic diseases.

Risks Associated With Denosumab Discontinuation

Risks Associated With Denosumab Discontinuation

Risk of vertebral fractures may be increased with discontinuation of denosumab therapy.

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

The task force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women ≥65 years and postmenopausal women.

Predicting Hypocalcemia in Children Following Thyroidectomy: Is PTH Level Useful?

Predicting Hypocalcemia in Children Following Thyroidectomy: Is PTH Level Useful?

While parathyroid hormone levels may be used to anticipate calcium decline, a "normal" PTH level does not always correctly predict postoperative calcium level.

Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk

Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

Poorly Controlled Rheumatoid Arthritis Increases T2D Risk

Poorly Controlled Rheumatoid Arthritis Increases T2D Risk

Type 2 diabetes is significantly underdiagnosed and undertreated in patients with rheumatoid arthritis.

Examining the Relationship Between Linear Growth and Bone Accrual in Children and Adolescents

Examining the Relationship Between Linear Growth and Bone Accrual in Children and Adolescents

Height gains "substantially outpaced" bone mineral content gains during childhood, potentially leading to increased fracture risk.

BMD and Physical Activity: Examining the Relationship in Class III Obesity

BMD and Physical Activity: Examining the Relationship in Class III Obesity

Both intensity of physical activity and time spent active can explain variability in femoral neck BMD in people with class III obesity.

New Bone Density Assessment Effectively Predicts Fracture Risk in Children

New Bone Density Assessment Effectively Predicts Fracture Risk in Children

A femoral stress index assessment evaluates fracture risk in children as effectively as femoral and total body bone mineral density.

Safety, Efficacy of Burosumab vs Placebo for X-Linked Hypophosphatemia Examined

Safety, Efficacy of Burosumab vs Placebo for X-Linked Hypophosphatemia Examined

In a double-blind multicenter study, researchers examined the safety and efficacy of burosumab for X-linked hypophosphatemia.

Can Anxiety or Depression Determine Low BMD in Patients With Anorexia?

Can Anxiety or Depression Determine Low BMD in Patients With Anorexia?

Both anxiety and depression scores are associated with low BMD.

Protective Effect of Hypoxia on Bone Health in Menopausal Women

Protective Effect of Hypoxia on Bone Health in Menopausal Women

Intermittent hypoxia in obstructive sleep apnea was found to decrease the chances of bone health decline in menopausal women.

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

A single bone mineral density measure and fracture history can predict long-term fracture risk in older women.

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

According to a study published in the Journal of Bone and Mineral Research, researchers hypothesized that serum K-Postn levels may be able to predict low-trauma fractures.

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

The effect of 1 year of cross-sex hormone therapy on bone mineral density was examined in transgender men and women.

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Daily supplementation with B vitamins and folic acid does not affect fracture risk for women with preexisting CV disease.

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

Researchers examined the benefits and risks associated with delaying ART initiation to slow bone mineral density loss.

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