The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.
There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.
A growing body of research highlights the important role of bone in glucose metabolism.
The risk for fragility fractures is significantly lower in women with osteopenia who receive zoledronate than in those who receive placebo.
Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.
Roux-en-Y gastric bypass is associated with bone density and skeletal microarchitecture deterioration, leading to substantial cumulative bone loss.
Bone attenuation was found to be an independent determinant for vertebral fractures in former smokers with and without chronic obstructive pulmonary disease.
Investigators assessed the effectiveness of intravenous ibandronate on bone mineral density in patients with osteoporosis who did not respond to oral bisphosphonates.
Glucocorticoid therapy was linked to significant bone deficits across multiple axial sites, regardless of disease activity.
MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture
Findings suggest potential pathomechanistic links between miRNAs and cortical porosity. .
Investigators sought to determine the effects of vitamin D3 supplementation in postmenopausal women with low serum 25(OH)D and high parathyroid hormone levels.
Early life exposures, such as maternal smoking and breastfeeding, may have effects on bone mineral density in young adulthood.
Bisphosphonate holidays of 3 to 5 years have been recommended as a means of achieving the antifracture benefit of the medication.
Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.
A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.
Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.
Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.
Investigators assessed the effect of exercise modality during dietary-induced on bone health.
Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.
Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.
Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.
Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.
A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.
Investigators compared biomarkers in patients who eventually developed radiographic osteolytic lesions to those who did not.
Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.
Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.
Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.
Romosozumab increased spine and hip bone mineral density after 12 months of treatment.
Screening with bone measurement is recommended for women. Younger women are at more risk.
High levels of serotonin are predictive of an increased risk for hip fracture, nonvertebral osteoporotic fracture, and incident fractures in older men.
Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.
Endocrinology Advisor Articles
- Heritability of BMI Stronger in Obesogenic Environments
- Maternal Gluten Intake Associated With Risk for Type 1 Diabetes in Offspring
- Bone-Derived Factors in the Treatment of Diabetes
- Deep Learning Algorithm Efficiently Detects Vision-Threatening Diabetic Retinopathy
- Thyroid Hormone Therapy Not Beneficial for Subclinical Hypothyroidism
- Bacillus Calmette-Guerin Vaccination Lowers HbA1c in Type 1 Diabetes
- Early Manifestations, Sex Differences May Aid in Acromegaly Diagnosis
- Predictive Variables for Permanent vs Transient Congenital Hypothyroidism
- Aetna-CVS Merger Approved
- The Progression of Health Care From Personalized Medicine to Wellness Genomics and Beyond