Bone Metabolism

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Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

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Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.

Urinary Biomarkers Can Help to Predict Peri-Implant Osteolysis

Urinary Biomarkers Can Help to Predict Peri-Implant Osteolysis

Investigators compared biomarkers in patients who eventually developed radiographic osteolytic lesions to those who did not.

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.

Romosozumab: Effective in Men With Osteoporosis

Romosozumab: Effective in Men With Osteoporosis

Romosozumab increased spine and hip bone mineral density after 12 months of treatment.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening with bone measurement is recommended for women. Younger women are at more risk.

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

High levels of serotonin are predictive of an increased risk for hip fracture, nonvertebral osteoporotic fracture, and incident fractures in older men.

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Serum intact parathyroid hormone levels may be an early marker to predict postthyroidectomy hypocalcemia.

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.

Hypoparathyroidism Treatment Granted Orphan Drug Designation

Hypoparathyroidism Treatment Granted Orphan Drug Designation

TransCon PTH is a long-acting prodrug of parathyroid hormone designed to restore PTH to physiologic levels, normalizing blood and urinary calcium levels, serum phosphate levels and bone turnover.

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.

Effects of ARB, Vitamin D3 on Parathyroid Hormone and Aldosterone

Effects of ARB, Vitamin D3 on Parathyroid Hormone and Aldosterone

Investigators examined whether short-term treatment with an angiotensin II receptor blocker and/or vitamin D3 reduced PTH levels.

Preterm Infant Vitamin D Level Affects Calcium and Bone Health

Preterm Infant Vitamin D Level Affects Calcium and Bone Health

Vitamin D levels in preterm infants are significantly correlated with optimal calcium homeostasis and bone mineralization of the femur.

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Negative effects of 2-hour glucose was pronounced at the cortical-bone-dominant sites in women.

Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday

Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday

For patients with osteopenia or osteoporosis, taking a bisphosphonate drug holiday is associated with increased risk of fracture for patients with lower femoral neck bone mineral density or T scores.

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.

Anxiety Levels Tied to Bone Mineral Density in Postmenopausal Women

Anxiety Levels Tied to Bone Mineral Density in Postmenopausal Women

Anxiety levels are associated with bone mineral density and fracture risk in the lumbar spine and femoral neck among postmenopausal women.

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.

Subclinical Thyroid Dysfunction Not Associated With Hip Fracture Risk in Older Men

Subclinical Thyroid Dysfunction Not Associated With Hip Fracture Risk in Older Men

Findings do not support a role for subclinical thyroid dysfunction as a biomarker for bone-related outcomes in older men.

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Researchers sought to determine the predictive value of tibiofemoral MRI, patellofemoral MRI, and KLG1 for the incidence of clinical or radiographic knee OA.

Fracture Type Varies for Women With Anorexia and Oligo-Amenorrheic Athletes

Fracture Type Varies for Women With Anorexia and Oligo-Amenorrheic Athletes

A high stress fracture rate in oligo-amenorrheic athletes, who have whole body, less head and hip, areal bone mineral density (BMD) measures comparable to those of control patients, indicates that BMD in these women may need to be even higher to avoid fractures.

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.

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