Bone Metabolism

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Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

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Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Timing of Serum Parathyroid Hormone Levels May Predict Postoperative Hypocalcemia

Serum intact parathyroid hormone levels may be an early marker to predict postthyroidectomy hypocalcemia.

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.

Hypoparathyroidism Treatment Granted Orphan Drug Designation

Hypoparathyroidism Treatment Granted Orphan Drug Designation

TransCon PTH is a long-acting prodrug of parathyroid hormone designed to restore PTH to physiologic levels, normalizing blood and urinary calcium levels, serum phosphate levels and bone turnover.

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.

Effects of ARB, Vitamin D3 on Parathyroid Hormone and Aldosterone

Effects of ARB, Vitamin D3 on Parathyroid Hormone and Aldosterone

Investigators examined whether short-term treatment with an angiotensin II receptor blocker and/or vitamin D3 reduced PTH levels.

Preterm Infant Vitamin D Level Affects Calcium and Bone Health

Preterm Infant Vitamin D Level Affects Calcium and Bone Health

Vitamin D levels in preterm infants are significantly correlated with optimal calcium homeostasis and bone mineralization of the femur.

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Negative effects of 2-hour glucose was pronounced at the cortical-bone-dominant sites in women.

Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday

Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday

For patients with osteopenia or osteoporosis, taking a bisphosphonate drug holiday is associated with increased risk of fracture for patients with lower femoral neck bone mineral density or T scores.

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.

Anxiety Levels Tied to Bone Mineral Density in Postmenopausal Women

Anxiety Levels Tied to Bone Mineral Density in Postmenopausal Women

Anxiety levels are associated with bone mineral density and fracture risk in the lumbar spine and femoral neck among postmenopausal women.

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.

Subclinical Thyroid Dysfunction Not Associated With Hip Fracture Risk in Older Men

Subclinical Thyroid Dysfunction Not Associated With Hip Fracture Risk in Older Men

Findings do not support a role for subclinical thyroid dysfunction as a biomarker for bone-related outcomes in older men.

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Researchers sought to determine the predictive value of tibiofemoral MRI, patellofemoral MRI, and KLG1 for the incidence of clinical or radiographic knee OA.

Fracture Type Varies for Women With Anorexia and Oligo-Amenorrheic Athletes

Fracture Type Varies for Women With Anorexia and Oligo-Amenorrheic Athletes

A high stress fracture rate in oligo-amenorrheic athletes, who have whole body, less head and hip, areal bone mineral density (BMD) measures comparable to those of control patients, indicates that BMD in these women may need to be even higher to avoid fractures.

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

The USPSTF has released recommendations for vitamin D and calcium supplementation for the primary prevention of fractures in community-dwelling adults.

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

Crysvita is an antibody that blocks fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses active vitamin D production by the kidney.

More Adverse Events and Higher Costs for Patients With RA on High-Dose Glucocorticoids

More Adverse Events and Higher Costs for Patients With RA on High-Dose Glucocorticoids

Investigators assessed the association between the cumulative dose of oral glucocorticoid treatment and expense associated with adverse events in patients with rheumatoid arthritis.

Thiazide Diuretic Use May Reduce Risk for Bone Fracture

Thiazide Diuretic Use May Reduce Risk for Bone Fracture

Thiazide diuretic use may convey a decreased risk of fracture and as such, the protective effect of this class of medicine should be considered when prescribing thiazide diuretics in clinical practice.

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

Researchers sought to identify associations of female reproductive factors with incidence of total knee arthroplasty in osteoarthritis.

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.

Diagnostic Value of Shear Wave Elastography for Parathyroid Adenomas

Diagnostic Value of Shear Wave Elastography for Parathyroid Adenomas

Shear wave elastography can be a useful tool in the preliminary diagnostics of parathyroid adenomas.

SSRIs Associated With Reduced Bone Mass Density in Older Patients

SSRIs Associated With Reduced Bone Mass Density in Older Patients

One reason selective serotonin reuptake inhibitors may affect the likelihood of osteoporosis is that the drug antagonizes the serotonin transporter, 5-HTT.

Bone Mineral Density Response Rates With Abaloparatide in Postmenopausal Women

Bone Mineral Density Response Rates With Abaloparatide in Postmenopausal Women

At the 43-month endpoint, a total of 60.7% (307/506) of the abaloparatide followed by alendronate group had ≥3% increase in bone mass at all 3 sites (P<0.0001) vs. 24% (121/505) of the placebo followed by alendronate group.

Glucocorticoid Use in COPD Does Not Increase Fracture Risk

Glucocorticoid Use in COPD Does Not Increase Fracture Risk

Intermittent use of high-dose glucocorticoids did not increase the risk for any, osteoporotic, hip, or clinically symptomatic vertebral fractures in patients with chronic obstructive pulmonary disease.

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Researchers have determined that treatment for osteoporosis with teriparatide is associated with greater bone formation than treatment with zoledronic acid.

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