Bone Metabolism

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Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

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Sleep Quality, Duration Affect Risk for Falls and Fractures in Older Women

Sleep Quality, Duration Affect Risk for Falls and Fractures in Older Women

Women who sleep poorly might be more likely to experience recurrent falls and bone fractures.

Bone Indices on CT Scan Predict Fracture Risk in Older Adults

Bone Indices on CT Scan Predict Fracture Risk in Older Adults

High-resolution peripheral quantitative computed tomography (HR-pQCT) indices improve prediction of fracture beyond bone mineral density and Fracture Risk Assessment Tool (FRAX) scores in older adults.

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

Statin use is associated with better cortical bone characteristics in older women with osteoporosis, but results are dependent upon the potency of the statins.

Lateral Spine Imaging for Vertebral Fractures May Improve Osteoporosis Detection

Lateral Spine Imaging for Vertebral Fractures May Improve Osteoporosis Detection

The use of lateral spine imaging to detect asymptomatic vertebral fractures in older women may improve osteoporosis identification.

Gestational Weight Gain and Offspring Bone Mineralization Outcomes

Gestational Weight Gain and Offspring Bone Mineralization Outcomes

There is a slight association between maternal gestational weight gain and offspring bone mineralization in under/normal weight women, but not in overweight/obese women.

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

Insulin resistance may play an intermediary role in the relationship between adiposity and lumbar spine bone mass in adolescents.

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia lead levels are associated with resistant-hypertension.

Childhood Participation in Sports Linked to Higher Adult Bone Mass

Childhood Participation in Sports Linked to Higher Adult Bone Mass

Children who are consistent sport participators have greater bone mineral content (BMC) at age 20 years.

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.

Zoledronate Lowers Fracture Risk in Women With Osteopenia

Zoledronate Lowers Fracture Risk in Women With Osteopenia

The risk for fragility fractures is significantly lower in women with osteopenia who receive zoledronate than in those who receive placebo.

Roux-en-Y Gastric Bypass Surgery Associated With Long-Term Bone Loss

Roux-en-Y Gastric Bypass Surgery Associated With Long-Term Bone Loss

Roux-en-Y gastric bypass is associated with bone density and skeletal microarchitecture deterioration, leading to substantial cumulative bone loss.

Fifteen Genetic Determinants of Fracture Identified

Fifteen Genetic Determinants of Fracture Identified

Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Investigators assessed the effect of exercise modality during dietary-induced on bone health.

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.

Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.

Urinary Biomarkers Can Help to Predict Peri-Implant Osteolysis

Urinary Biomarkers Can Help to Predict Peri-Implant Osteolysis

Investigators compared biomarkers in patients who eventually developed radiographic osteolytic lesions to those who did not.

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.

Romosozumab: Effective in Men With Osteoporosis

Romosozumab: Effective in Men With Osteoporosis

Romosozumab increased spine and hip bone mineral density after 12 months of treatment.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening with bone measurement is recommended for women. Younger women are at more risk.

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

High levels of serotonin are predictive of an increased risk for hip fracture, nonvertebral osteoporotic fracture, and incident fractures in older men.

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.

Preterm Infant Vitamin D Level Affects Calcium and Bone Health

Preterm Infant Vitamin D Level Affects Calcium and Bone Health

Vitamin D levels in preterm infants are significantly correlated with optimal calcium homeostasis and bone mineralization of the femur.

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Negative effects of 2-hour glucose was pronounced at the cortical-bone-dominant sites in women.

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