Bone Metabolism Archive

Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday

Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday

For patients with osteopenia or osteoporosis, taking a bisphosphonate drug holiday is associated with increased risk of fracture for patients with lower femoral neck bone mineral density or T scores.

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.

Anxiety Levels Tied to Bone Mineral Density in Postmenopausal Women

Anxiety Levels Tied to Bone Mineral Density in Postmenopausal Women

Anxiety levels are associated with bone mineral density and fracture risk in the lumbar spine and femoral neck among postmenopausal women.

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Researchers sought to determine the predictive value of tibiofemoral MRI, patellofemoral MRI, and KLG1 for the incidence of clinical or radiographic knee OA.

Fracture Type Varies for Women With Anorexia and Oligo-Amenorrheic Athletes

Fracture Type Varies for Women With Anorexia and Oligo-Amenorrheic Athletes

A high stress fracture rate in oligo-amenorrheic athletes, who have whole body, less head and hip, areal bone mineral density (BMD) measures comparable to those of control patients, indicates that BMD in these women may need to be even higher to avoid fractures.

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

The USPSTF has released recommendations for vitamin D and calcium supplementation for the primary prevention of fractures in community-dwelling adults.

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

Crysvita is an antibody that blocks fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses active vitamin D production by the kidney.

More Adverse Events and Higher Costs for Patients With RA on High-Dose Glucocorticoids

More Adverse Events and Higher Costs for Patients With RA on High-Dose Glucocorticoids

Investigators assessed the association between the cumulative dose of oral glucocorticoid treatment and expense associated with adverse events in patients with rheumatoid arthritis.

Thiazide Diuretic Use May Reduce Risk for Bone Fracture

Thiazide Diuretic Use May Reduce Risk for Bone Fracture

Thiazide diuretic use may convey a decreased risk of fracture and as such, the protective effect of this class of medicine should be considered when prescribing thiazide diuretics in clinical practice.

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

Researchers sought to identify associations of female reproductive factors with incidence of total knee arthroplasty in osteoarthritis.

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.

SSRIs Associated With Reduced Bone Mass Density in Older Patients

SSRIs Associated With Reduced Bone Mass Density in Older Patients

One reason selective serotonin reuptake inhibitors may affect the likelihood of osteoporosis is that the drug antagonizes the serotonin transporter, 5-HTT.

Glucocorticoid Use in COPD Does Not Increase Fracture Risk

Glucocorticoid Use in COPD Does Not Increase Fracture Risk

Intermittent use of high-dose glucocorticoids did not increase the risk for any, osteoporotic, hip, or clinically symptomatic vertebral fractures in patients with chronic obstructive pulmonary disease.

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Researchers have determined that treatment for osteoporosis with teriparatide is associated with greater bone formation than treatment with zoledronic acid.

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

Researchers investigated the effects of growth hormone vs placebo, as well as the effects of sex steroid replacement therapy on bone mineral density in growth hormone-treated young adults with Prader-Willi syndrome who had attained adult height.

Vitamin D Associated With Improved Bone Health in Epilepsy

Vitamin D Associated With Improved Bone Health in Epilepsy

In this review, 2 independent investigators searched clinical trial databases for studies that evaluated the link between vitamin D supplements and bone health in adult patients with epilepsy.

Abatacept May Improve Femoral Neck Bone Mineral Density in Rheumatoid Arthritis

Abatacept May Improve Femoral Neck Bone Mineral Density in Rheumatoid Arthritis

Abatacept was superior at increasing bone mineral density in the femoral neck compared with other biologic disease-modifying antirheumatic drugs, and may offer good efficacy for improving BMD in rheumatoid arthritis.

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

Researchers showed that decreased L1 trabecular attenuation is associated with increased risk for future osteoporotic fractures in adult patients aged ≥65 years undergoing abdominopelvic CT scans for other indications.

Damaging Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture

Damaging Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture

Researchers observed detrimental effects of RYGB on bone turnover, mass, structure, and strength just 6 months postoperatively, and these effects persisted throughout the duration of the 12-month study.

Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis

Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis

The use of biologic disease-modifying antirheumatic drugs has no medium-term effect on the risk for spinal fractures among patients with ankylosing spondylitis.

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

Study assessed the effect of denosumab on bone mineral density and incident fractures in older adults with primary hyperparathyroidism who could not undergo or refused surgery.

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

A lower bone mineral density in the lumbar spine, femoral neck, and hip is associated with an increased risk for intracranial aneurysm.

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

In postmenopausal women at high risk for fracture, treatment with romosozumab for 12 months, followed by alendronate, was associated with significantly fewer hip fractures than treatment with alendronate alone.

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

A recent literature review and meta-analysis indicates that growth hormone therapy may reduce the risk for fracture in patients with osteoporosis.

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

New findings do not support routine vitamin D and calcium supplementation in community-dwelling older adults for lowering the incidence of osteoporosis-related fractures.

Prevention of Bone Mineral Density Loss Needed in Epilepsy

Prevention of Bone Mineral Density Loss Needed in Epilepsy

Researchers conducted a long-term follow-up study to determine whether BMD loss, osteoporosis, and fractures were successfully treated or prevented in an urban population of patients with epilepsy and reduced bone density.

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide is associated with a lower risk for new vertebral and clinical fractures compared with risedronate in post-menopausal women being treated for severe osteoporosis.

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

The association between alendronate use and nonvertebral fracture was strongest in patients who received high doses of glucocorticoid.

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Risks Associated With Denosumab Discontinuation

Risks Associated With Denosumab Discontinuation

Risk of vertebral fractures may be increased with discontinuation of denosumab therapy.

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

The task force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women ≥65 years and postmenopausal women.

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

A single bone mineral density measure and fracture history can predict long-term fracture risk in older women.

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

According to a study published in the Journal of Bone and Mineral Research, researchers hypothesized that serum K-Postn levels may be able to predict low-trauma fractures.

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

The effect of 1 year of cross-sex hormone therapy on bone mineral density was examined in transgender men and women.

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Daily supplementation with B vitamins and folic acid does not affect fracture risk for women with preexisting CV disease.

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

Researchers examined the benefits and risks associated with delaying ART initiation to slow bone mineral density loss.

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

Bone mineral density of the femoral neck, a significant predictor of fracture risk, declined nearly twice as quickly in HIV-infected women compared with HIV-infected men.

FDA Requests Additional Data in Romosozumab Biologics License Application

FDA Requests Additional Data in Romosozumab Biologics License Application

The FDA has requested data from 2 additional phase 3 clinical trials analyzing the safety and effectiveness of romosozumab, Amgen, Inc. and UCB's joint osteoporosis drug.

Bone Mineral Density Decline With Immediate Antiretroviral Tx in HIV

Bone Mineral Density Decline With Immediate Antiretroviral Tx in HIV

Changes in bone mineral density at 1 year were similar in the immediate and delayed ART groups.

Does Sedative Use Increase Repeat Fall Risk?

Does Sedative Use Increase Repeat Fall Risk?

Daytime sleepiness and poor quality of sleep affect recurrent fall risk in the elderly.

Colecalciferol Did Not Reduce Fracture or Fall Risks

Colecalciferol Did Not Reduce Fracture or Fall Risks

Healthy middle-age patients who took colecalciferol did not have a reduced risk for fall or fracture.

Fracture Risk Cut With Low Level of Physical Activity

Fracture Risk Cut With Low Level of Physical Activity

Twenty minutes per day of walking or bicycling were associated with a lower rate of fracture.

Examining the Relationship Between Weight Loss and Knee Degeneration

Examining the Relationship Between Weight Loss and Knee Degeneration

Participants who lost between 5% and 10% or more than 10% of their body weight slowed knee joint degeneration, compared to those who maintained their current weight.

Sleeping Pills and Fracture Risk: Is There A Link?

Sleeping Pills and Fracture Risk: Is There A Link?

A 2.5 times higher fracture risk was noted among elderly patients taking sleeping pills.

Fracture Risk Decreases, Bone Mineral Density Increases With Long-Term Denosumab

Fracture Risk Decreases, Bone Mineral Density Increases With Long-Term Denosumab

Long-term denosumab increased bone mineral density in postmenopausal women.

Increasing Bone Mineral Density in Older Men

Increasing Bone Mineral Density in Older Men

After 1 year of therapy, men who underwent testosterone therapy experienced improvement in bone mineral density and mood.

ACP: Updated Osteoporosis Treatment Guidelines

ACP: Updated Osteoporosis Treatment Guidelines

An update to the 2008 ACP osteoporosis treatment guidelines focuses on treating low bone density and osteoporosis in an effort to prevent fractures.

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Tuberculosis was identified as an independent risk factor associated with incident osteoporosis.

Oral Contraceptives May Reduce Fracture Risk

Oral Contraceptives May Reduce Fracture Risk

Women who had taken oral contraceptives for more than 5 years had the lowest risk for fracture.

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Eighty-four percent of survey respondents did not undergo osteoporosis pharmacotherapy following an osteoporosis-related fracture.

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

Tymlos approval was based on the results of the ACTIVE and ACTIVExtension trials.

Physical Activity, Sedentary Time and Bone Strength Association in Teens

Physical Activity, Sedentary Time and Bone Strength Association in Teens

Moderate-to-vigorous physical activity was found to be an independent predictor of bone strength in adolescents.

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

The most common adverse events associated with long-term denosumab use were back, musculoskeletal, or extremity pain, hypercholesterolemia, and cystis.

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

The most important predictor for use of osteoporosis care was receiving primary care services within 6 months following hip fracture.

Is DXA Required to Diagnose Vertebral Fracture in Patients With Low BMD?

Is DXA Required to Diagnose Vertebral Fracture in Patients With Low BMD?

Researchers compared the efficacy of dual-energy x-ray absorptiometry with lateral x-ray in assessing vertebral fractures.

Accuracy of Trabecular Bone Score to Assess Fragility Fracture Risk in T1D

Accuracy of Trabecular Bone Score to Assess Fragility Fracture Risk in T1D

Fragility fracture risk increased with older age and decreased with higher bone mineral density in patients with type 1 diabetes.

Bone Age in Children as Assessed by Dual-Energy X-Ray and Radiography

Bone Age in Children as Assessed by Dual-Energy X-Ray and Radiography

Using dual-energy X-ray absorptiometry for bone age assessment complements traditional radiologic assessment.

Leg Positioning During Lumbar Spine DXA

Leg Positioning During Lumbar Spine DXA

Researchers evaluated trabecular bone scores in more than 100 women during either "legs up" or "legs down" dual energy x-ray absorptiometry scans.

DXA-Visceral Adipose Tissue Measurements in Atherosclerotic CVD Risk Assessment

DXA-Visceral Adipose Tissue Measurements in Atherosclerotic CVD Risk Assessment

Neither DXA-visceral adipose tissue nor android-gynoid fat mass ratios were associated with atherosclerotic cardiovascular disease events.

TeleECHO Clinic Improves Physician Confidence in Osteoporosis Care

TeleECHO Clinic Improves Physician Confidence in Osteoporosis Care

The Bone Health TeleECHO Clinic helps telementor healthcare professionals and improves osteoporosis care in underserved communities.

Testosterone Increases Lumbar Spine Volumetric Trabecular BMD in Older Men

Testosterone Increases Lumbar Spine Volumetric Trabecular BMD in Older Men

Testosterone treatment improved both bone mineral density and strength in older men.

How Does Antenatal Betamethasone Exposure Affect Pediatric Bone Mass?

How Does Antenatal Betamethasone Exposure Affect Pediatric Bone Mass?

The effects of repeat doses of antenatal betamethasone were assessed in 185 eligible pediatric patients.

Anti-fracture Therapy Effectively Prevents Bone Loss in Women Post-Critical Illness

Anti-fracture Therapy Effectively Prevents Bone Loss in Women Post-Critical Illness

Researchers found that female patients recovering from critical illness respond better to anti-fracture therapy for bone mineral density loss prevention compared with men.

Do Bone Turnover Markers Predict Vertebral Fracture Risk Post-Alendronate Discontinuation?

Do Bone Turnover Markers Predict Vertebral Fracture Risk Post-Alendronate Discontinuation?

Study examines the predictive value for vertebral fractures of bone mineral density and bone turnover markers after a 5-year drug holiday.

Metabolic Bone Toxicity Possible With Certain Hepatitis Antivirals

Metabolic Bone Toxicity Possible With Certain Hepatitis Antivirals

The long-term effects of several hepatitis virus antivirals on various aspects of bone metabolism are unclear.

Hepatitis B Therapy Associated With Abnormal Bone Metabolism

Hepatitis B Therapy Associated With Abnormal Bone Metabolism

Patients taking tenofovir should aim to maximize the phosphorous in their diet.

Risk of Mortality Post-Fragility Fracture Is Sex Dependent

Risk of Mortality Post-Fragility Fracture Is Sex Dependent

Ankle fractures presented similar mortality rates between men and women, while other types of fractures had higher mortality rates among men.

Oral Bisphosphonate Prescription Trends Shifted After 2008 Recommendations

Oral Bisphosphonate Prescription Trends Shifted After 2008 Recommendations

Two distinct time trends were observed in initiation of oral bisphosphonates in women after the 2008 updated osteoporosis treatment guidelines.

Fracture Risk in Psoriatic Arthritis, Psoriasis Examined

Fracture Risk in Psoriatic Arthritis, Psoriasis Examined

Patients with psoriatic arthritis or psoriasis had an increased prevalence of osteoporosis risk factors.

FDA Clears Point-of-Care Device for Diagnosing Osteoporosis

FDA Clears Point-of-Care Device for Diagnosing Osteoporosis

Bone Index announced that the Food and Drug Administration (FDA) has granted clearance for the second generation Bindex device model to aid in the diagnosis of osteoporosis.

Bone Density Linked to Vascular Calcification in ESRD

Bone Density Linked to Vascular Calcification in ESRD

A prospective cohort study in 66 patients with end-stage renal disease was conducted to determine the link between renal and coronary heart diseases.

Alzheimer's Disease: Risk Factor for Hip Fracture

Alzheimer's Disease: Risk Factor for Hip Fracture

Cardiovascular disease, stroke, diabetes, hip and knee replacements, and both behavioral and mental disorders were also more common in the Alzheimer's disease cohort.

Etelcalcetide Examined in Hemodialysis Patients With Secondary Hyperparathyroidism

Etelcalcetide Examined in Hemodialysis Patients With Secondary Hyperparathyroidism

Etelcalcetide shows promise for reducing parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.

Malignancy Risk & Vitamin D Deficiency: An Unclear Relationship

Malignancy Risk & Vitamin D Deficiency: An Unclear Relationship

According to the National Cancer Institute, there are not enough available data to establish whether taking vitamin D can prevent cancer.

Less Frequent Dosing of Bisphosphonate in Patients With Bone Metastases

Less Frequent Dosing of Bisphosphonate in Patients With Bone Metastases

Less frequent dosing with zoledronic acid does not increase fracture risk in patients with bone metastases.

Long-Term DPP-4 Inhibitor Use Not Associated With Fracture Risk in Type 2 Diabetes

Long-Term DPP-4 Inhibitor Use Not Associated With Fracture Risk in Type 2 Diabetes

For patients with type 2 diabetes, long-term use of dipeptidyl peptidase-4 (DPP-4) inhibitors is not associated with fracture risk.

VIDEO: Clinical Trial Results for Abaloparatide

Lorraine Fitzpatrick, MD, discusses updated results from the ACTIVE phase 3 clinical trial.

Does Antihypertensive Medication Class Affect Fracture Risk?

Does Antihypertensive Medication Class Affect Fracture Risk?

Researchers compared 3 classes of antihypertensive medication to determine hip and pelvic fracture risk in users vs nonusers.

New Osteoporosis Treatment Options on the Horizon

Nancy E. Lane, MD, professor of medicine, at the University of California at Davis School of Medicine, discusses results from the phase 3 ACTIVE trial.

Bone Density Lower Among Heavy Cannabis Users

Bone Density Lower Among Heavy Cannabis Users

Heavy cannabis users have lower bone density compared to cigarette smokers.

Stimulant Use Associated With Lower Bone Mass in Children, Teens

Stimulant Use Associated With Lower Bone Mass in Children, Teens

Children and teens who used stimulants for attention-deficit/hyperactivity disorder had lower bone mineral content and bone density than nonusers.

Bone Mineral Density Linked to Concentrations of 25(OH)D in Summer

Bone Mineral Density Linked to Concentrations of 25(OH)D in Summer

Summer levels of serum 25-hydroxyvitamin D are associated with bone mineral density of the total hip.

AACE/ACE Updates Postmenopausal Osteoporosis Management Guidelines

AACE/ACE Updates Postmenopausal Osteoporosis Management Guidelines

The American Association of Clinical Endocrinologists (AACE) and the American College of Endocrinology (ACE) announced the publication of new clinical guidelines and an accompanying algorithm to help physicians and other health care professionals with the diagnosis, fracture risk assessment, and treatment of postmenopausal osteoporosis.

Fracture Risk in Diabetes No Higher With Sitagliptin

Fracture Risk in Diabetes No Higher With Sitagliptin

According to results from the TECOS trial, sitagliptin is not linked to an increased risk for fractures in patients with diabetes.

Risk for Secondary Hyperparathyroidism Up With Furosemide Use

Risk for Secondary Hyperparathyroidism Up With Furosemide Use

Study reveals 6-fold higher risk of secondary hyperparathyroidism in patients on furosemide vs hydrochlorothiazide.

Does Personality Influence Risk for Falls in Women?

Does Personality Influence Risk for Falls in Women?

Optimism is associated with a decreased fall risk and cynical hostility with an increased fall risk for women.

Predictors of Atherosclerosis Progression in African Americans With Type 2 Diabetes

Predictors of Atherosclerosis Progression in African Americans With Type 2 Diabetes

Higher pericardial adipose volumes were associated with increases in calcified atherosclerotic plaque.

Adipose Stores of Vitamin D Greater in Obese Women

Adipose Stores of Vitamin D Greater in Obese Women

Obese women have significantly greater total vitamin D stores than normal-weight women, although the pattern of distribution of the stores is similar.

Fracture Risk Lower With Abaloparatide in Osteoporosis

Fracture Risk Lower With Abaloparatide in Osteoporosis

In postmenopausal women with osteoporosis, an experimental drug appears to reduce the risk of bone fractures better than teriparatide or a placebo.

Soy Isoflavone May Improve Bone Health After Menopause

Soy Isoflavone May Improve Bone Health After Menopause

For postmenopausal women, soy isoflavone supplementation is associated with improvement in bone health.

New Index Predicts Women at Risk for Rapid Bone Loss During Menopausal Transition

New Index Predicts Women at Risk for Rapid Bone Loss During Menopausal Transition

An index accounting for both bone formation and resorption may help identify which women may experience faster bone loss during menopause.

Treatment-Related Changes in Bone Density Linked to Fracture Risk in Osteoporosis

Treatment-Related Changes in Bone Density Linked to Fracture Risk in Osteoporosis

For women initiating osteoporosis treatment, treatment-related changes in total hip bone mineral density (BMD) are associated with fracture risk.

Hormone Replacement Therapy vs Combination Oral Contraceptive for Bone Health in Premature Ovarian Failure

Hormone Replacement Therapy vs Combination Oral Contraceptive for Bone Health in Premature Ovarian Failure

In women with premature ovarian failure, hormone replacement therapy was associated with greater increases in bone mineral density.

Risk for Death Increased With Osteogenesis Imperfecta

Risk for Death Increased With Osteogenesis Imperfecta

Patients with osteogenesis imperfecta have an elevated risk for death, according to a study published in the Journal of Bone and Mineral Research.

Long-Term rhPTH(1-84) Associated With Reduced Need for Calcium, Calcitriol Supplements

Long-Term rhPTH(1-84) Associated With Reduced Need for Calcium, Calcitriol Supplements

The therapy was also associated with reduced urinary calcium excretion and stable serum calcium concentration in patients with hypoparathyroidism.

Bone Health Adversely Affected by HIV Infection With T-Cell Activation

Bone Health Adversely Affected by HIV Infection With T-Cell Activation

HIV-infection and T-cell activation are linked to decreased number of osteogenic precursors.

Proton Pump Inhibitor Use Increases Risk of Osteoporosis and Osteopenia in Femur

Proton Pump Inhibitor Use Increases Risk of Osteoporosis and Osteopenia in Femur

Proton pump inhibitor users had reduced mean femoral T-scores and increased frequency of osteoporosis and osteopenia.

Dietary Calcium Intake Has U-Shaped Correlation With Fracture Risk

Dietary Calcium Intake Has U-Shaped Correlation With Fracture Risk

Researchers examined the long-term correlations between low dietary calcium intake and fracture risk in older adults with a plant-based diet.

FRAX Tool May Overestimate Fracture Risk in Rheumatoid Arthritis Patients

FRAX Tool May Overestimate Fracture Risk in Rheumatoid Arthritis Patients

The United Kingdom Fracture Risk Assessment Tool overestimated fracture risk in rheumatoid arthritis patients compared with the general population.

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