Vilas Patwardhan

I. What every physician needs to know. Primary sclerosing cholangitis (PSC) is a disorder of unknown etiology, likely autoimmune, which affects the biliary tree. It is characterized by progressive inflammation and sclerosis of the intra- and extrahepatic bile ducts. It is most commonly seen in association with inflammatory bowel disease (IBD), with ulcerative colitis being…

Drug-induced liver disease I. Problem/Condition. Drug-induced liver disease is defined as liver injury related to a specific drug. It can manifest as an asymptomatic elevation in liver chemistries or symptomatically with liver dysfunction. In rare cases, patients may progress to fulminant hepatic failure. It can be either acute or chronic and can vary in its…