Harry L Malech

All articles by Harry L Malech

Chronic granulomatous disease

Chronic granulomatous disease What every physician needs to know: Background Chronic granulomatous disease (CGD) is a deficiency of microbicidal oxidant production affecting neutrophils, eosinophils, monocytes, and some tissue macrophages. There are five genetic forms of CGD affecting different subunits of the phagocyte NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (gp91phox, p47phox, p22phox, p67phox, p40phox). X-linked CGD…

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