Androgen and Reproductive Disorders

Primary Characteristics of PCOS Predictive of Obstetric Complications

Primary Characteristics of PCOS Predictive of Obstetric Complications

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Preconception hyperandrogenism and impaired glucose tolerance are predictive of multiple obstetric and perinatal complications in women with PCOS.

Testosterone Use Remains High Among Men With Coronary Artery Disease

Testosterone Use Remains High Among Men With Coronary Artery Disease

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Despite research suggesting that there may be increased cardiovascular risk from off-label prescription testosterone use, usage in men with coronary artery disease remains higher than in men without coronary artery disease.

Topical Methyl Estradiolpropanoate Safe, Effective for Treating Estrogen-Deficient Skin

Topical Methyl Estradiolpropanoate Safe, Effective for Treating Estrogen-Deficient Skin

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A study was conducted to assess the safety, tolerability, and efficacy of methyl estradiolpropanoate, a topical soft estrogen cosmeceutical for the treatment of estrogen-deficient skin.

Higher Risk for Venous Thromboembolism With Oral vs Transdermal HRT

Higher Risk for Venous Thromboembolism With Oral vs Transdermal HRT

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Oral preparations of hormone replacement therapy for the treatment of menopausal symptoms are associated with a greater risk for VTE compared with transdermal formulations.

Women With Low Birth Weight at Higher Risk for Gestational Diabetes, Hypertension

Women With Low Birth Weight at Higher Risk for Gestational Diabetes, Hypertension

Women born with a low birth weight have an increased risk for pregnancy complications.

High Levels of Androgens in Men Associated With Increased Risk for Anxiety Disorders

High Levels of Androgens in Men Associated With Increased Risk for Anxiety Disorders

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Higher serum total testosterone in men and androstenedione in young men may increase the risk for anxiety disorders.

Genome-Wide PCOS Studies Suggest Correlations With Metabolic, Neuroendocrine Pathways

Genome-Wide PCOS Studies Suggest Correlations With Metabolic, Neuroendocrine Pathways

Three novel loci have been identified for polycystic ovary syndrome.

Assessing Inequalities in Infertility Care Among Women

Assessing Inequalities in Infertility Care Among Women

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Internationally, infertility is ranked as the fifth most serious disability among women.

Vaginal Estrogen Use Not Associated With Elevated Chronic Disease Risk

Vaginal Estrogen Use Not Associated With Elevated Chronic Disease Risk

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Vaginal estrogen use or nonuse did not carry different risks for cardiovascular outcomes, cancer outcomes, or hip fracture.

FDA Announces Safety Monitoring Measures for Permanent Birth Control Essure

FDA Announces Safety Monitoring Measures for Permanent Birth Control Essure

The U.S. Food and Drug Administration is implementing a number of steps for long-term safety monitoring of the permanent birth control device Essure, which will no longer be sold or distributed in the United States after Dec. 31, 2018.

Edentulism Associated With Risk for Hypertension After Menopause

Edentulism Associated With Risk for Hypertension After Menopause

Postmenopausal women with edentulism are at an increased risk for developing hypertension.

Approximately 65% of Women in the United States Are Using Contraceptives

Approximately 65% of Women in the United States Are Using Contraceptives

Almost two-thirds of U.S. women aged 15 to 49 years were currently using contraception in 2015 to 2017.

Menopause Symptoms Associated With Intimate Partner Violence, Sexual Assault

Menopause Symptoms Associated With Intimate Partner Violence, Sexual Assault

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Intimate partner violence, sexual assault, and symptoms of posttraumatic stress disorder may be associated with menopause symptoms.

Interpregnancy Period Should Maximize Women's Health

Interpregnancy Period Should Maximize Women's Health

Providers should maximize women's health during the interpregnancy period, continuing care beyond the immediate postpartum period.

Health Risks Associated With Androgenic Anabolic Steroid Use in Men

Health Risks Associated With Androgenic Anabolic Steroid Use in Men

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Men who use androgenic anabolic steroids have an increased mortality risk, a notable increase in hospitalizations, and higher prevalence of certain disorders compared with the general population.

Duration of Infertility Associated With Sperm Concentration in Men

Duration of Infertility Associated With Sperm Concentration in Men

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A longer duration of infertility was associated with lower sperm concentrations and higher rates of azoospermia in men with primary infertility.

Prenatal Exposure to Famine Increases Risk for Early Menopause

Prenatal Exposure to Famine Increases Risk for Early Menopause

Fetal exposure to famine is associated with an increased risk for early menopause.

Reduced Fertility in Obese Women May Be Related to Dysfunctional Insulin Pathway

Reduced Fertility in Obese Women May Be Related to Dysfunctional Insulin Pathway

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A high BMI is associated with reduced follicle-stimulating hormone receptor expression in human chorionic gonadotropins, reduced expression of estradiol synthesis-related genes, and reduced production of estradiol.

Urinary Incontinence Drug May Reduce Frequency of Hot Flashes

Urinary Incontinence Drug May Reduce Frequency of Hot Flashes

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Oxybutynin, an anticholinergic used to treat urinary incontinence, may provide breast cancer survivors with an alternative treatment option for hot flashes, according to new research.

Five-Year Efficacy Data Announced for Liletta Intrauterine System

Five-Year Efficacy Data Announced for Liletta Intrauterine System

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Phase 3 trial results assessing the intrauterine system, Liletta (levonorgestrel 52 mg), found that it had >99% efficacy in preventing pregnancy for up to 5 years; the products current Food and Drug Administration indication.

Endocrine-Disrupting Chemicals in Personal Care Products Linked to Early Puberty

Endocrine-Disrupting Chemicals in Personal Care Products Linked to Early Puberty

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Exposure to certain endocrine disrupting chemicals may impact timing of puberty in children.

Menopausal Hormone Therapy May Reduce Carpal Tunnel Syndrome Risk

Menopausal Hormone Therapy May Reduce Carpal Tunnel Syndrome Risk

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To investigate the association between hormone therapy and carpal tunnel syndrome risk, researchers conducted a secondary analysis of the Women's Health Initiative (WHI) hormone therapy trials.

Age-Related Vaginal Symptoms Associated With Worse Quality of Life

Age-Related Vaginal Symptoms Associated With Worse Quality of Life

Severe vulvovaginal atrophy (VVA) symptoms are associated with worse quality of life in postmenopausal women.

FDA to Review Estrogen-Free Oral Contraceptive Slinda

FDA to Review Estrogen-Free Oral Contraceptive Slinda

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Drospirenone is a spironolactone analogue with antimineralocorticoid and antiandrogenic activity.

Sleep Quality in Women With Surgical vs Natural Menopause

Sleep Quality in Women With Surgical vs Natural Menopause

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Women who undergo surgical menopause have significantly worse sleep quality than those who experience natural menopause.

Xyosted Now Available for Treatment of Testosterone Deficiency

Xyosted Now Available for Treatment of Testosterone Deficiency

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Prior to starting Xyosted, the patient's baseline cardiovascular risk should be considered and blood pressure should be adequately controlled.

Male Contraceptive Gel to Be Evaluated in Clinical Trial

Male Contraceptive Gel to Be Evaluated in Clinical Trial

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The year-long Phase 2b trial, funded by the National Institutes of Health, will enroll approximately 420 couples that are seeking pregnancy prevention across 3 US sites (Los Angeles, Seattle, and Kansas City).

Testosterone Treatment Reduces Symptoms of Depression in Men

Testosterone Treatment Reduces Symptoms of Depression in Men

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In a select sample of men, testosterone treatment in higher doses was observed to be effective for reducing depressive symptoms.

Testosterone Therapy and Measures of Mobility in Older Men

Testosterone Therapy and Measures of Mobility in Older Men

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In older men with low testosterone concentrations, testosterone therapy improves self-reported walking ability and outcomes on the 6-minute walking test.

Psychosocial Risks Associated With Central Precocious Puberty

Psychosocial Risks Associated With Central Precocious Puberty

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In addition to the risk that children with CPP will not reach their adult height potential, a range of studies have noted a high risk for psychological, social, and behavioral problems in this population.

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