Androgen and Reproductive Disorders Archive
Approval from the Food and Drug Administration (FDA) was supported by the Phase 3 Replenish trial which evaluated the safety and efficacy of Bijuva in generally healthy, postmenopausal women with a uterus for the treatment of moderate to severe hot flashes.
Compared with women who experience normal or late menopause, women who experience early natural menopause have a shorter life expectancy and spend fewer years without type 2 diabetes.
Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.
During 2007 to 2017, fertility rates decreased in the United States for each urbanization level.
Middle-aged testosterone replacement therapy users with COPD had a greater reduction in hospitalizations compared with nonusers.
The expanded approval was supposed by safety and efficacy data from the Phase 3 ACCESS IUS trial (N = 1751) in women receiving Liletta. In the trial, Liletta demonstrated >99% efficacy in preventing pregnancy for up to 5 years in a broad patient population.
Daily oral administration of dimethandrolone undecanoate for 28 days in healthy men is well tolerated and has properties consistent with an effective male contraceptive.
Postmenopausal women with weight loss have a reduced risk for breast cancer.
Xyosted carries a Boxed Warning regarding blood pressure increases that may potentially increase the risk for major adverse cardiovascular events.
Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.
Researchers concluded that physical activity was not associated with risk for early menopause.
Healthy nonmenopausal women taking oral contraceptives exhibited biomarkers for drug-induced torsade de pointes.
The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).
Investigators assessed whether adrenal suppression with low-dose dexamethasone improved IVF outcomes.
Investigators sought to determine the effect of vitamin D deficiency on the success of ovarian stimulation in women with PCOS or unexplained infertility.
Investigators examine total testosterone, free testosterone, and sex hormone binding globulin levels in pregnant women in the third trimester with PCOS.
For this study, researchers investigated the incidence of primary ovarian insufficiency incidence and estimated risk for POI after vaccination with human papillomavirus, Tdap, influenza and meningococcal conjugate using Kaiser Permanente Northwest electronic health records from 2006 to 2014.
This finding suggests that clinicians should monitor anxiety among individuals with testosterone deficiency and XXY.
Investigators examined the relationship between menstrual cycle characteristics in adolescence and early adulthood and the risk for early natural menopause.
Cytovene-IV is a deoxynucleoside analogue cytomegalovirus (CMV) DNA polymerase inhibitor.
The American Medical Association strongly objects to the Trump administration's plan to withhold federal family planning funding from Planned Parenthood and other entities.
The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.
Can Weight Gain After Smoking Cessation Be Reduced By Increasing Physical Activity in Postmenopausal Women?
Investigators examined whether increase in physical activity may reduce weight gain after smoking cessation in postmenopausal women.
Amid lawsuits and plummeting sales for its Essure birth control device, Bayer announced Friday that it would cease U.S. sales of the product by the end of 2018.
No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms
Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.
In 2014, the US Food and Drug Administration issued a safety bulletin for the use of testosterone.
Investigators aimed to determine the prevalence of fatigue in women diagnosed with endometriosis.
Investigators aimed to determine the level of midluteal progesterone associated with low probability of live birth following intrauterine insemination.
Only half of patients with initial treatment success maintain benefits at two years.
Symptoms more likely in those reporting fair health, history of non-spontaneous menopause
Menopausal hormone therapy may slow cognitive decline in postmenopausal women with mild cognitive impairment.
Researchers sought to determine whether the reduced mortality seen in women receiving reproductive assistance occurred as a result of improved general health in this population.
These analyses may serve clinicians in addressing potential psychiatric obstacles in patients undergoing fertility treatments.
The case study focused on the story of a clinician who arrived in Lebanon to discuss how to best offer infertility treatment to Syrian refugees in the region.
To evaluate safety and efficacy of this therapy, study authors gathered data on patients treated with the combination from 2014 to 2017.
Men with higher estradiol and estradiol/testosterone levels had an increased risk for pulmonary arterial hypertension.
Serum chemerin may serve as a biomarker to identify pregnant women with polycystic ovary syndrome who are at particular risk for later abortion, and who may benefit from prevention strategies.
Meta-analysis shows that alcohol intake is moderately associated with premenstrual syndrome risk.
Metformin treatment during pregnancy did not influence the metabolic profile in women with polycystic ovary syndrome at 7.7 years of follow-up.
These data confirmed the increased risk for psychiatric disorders in women with PCOS, and indicated an increased risk for ADHD and ASD in their children.
Clinicians should use a total testosterone level below 300ng/dL as a reasonable cut-off in support of the diagnosis of low testosterone.
Researchers evaluated the association between PCOS and psychiatric outcomes, as well as whether rates of autism spectrum disorder and attention-deficit/hyperactivity disorder are higher in children of mothers with PCOS.
A number of adverse events or side effects have been reported, but this is the first report of hyperprolactinemia as the result of ingestion of kratom.
Bremelanotide, an investigational product, is thought to possess a novel mechanism of action, activating endogenous melanocortin pathways involved in sexual desire and response.
Researchers conducted a prospective, population-based cohort study to assess the risk for cardiovascular disease in postmenopausal women with increased androgen levels.
The management of asthma with short-acting beta-agonists was associated with reduced fertility rates in women, whereas treatment with inhaled corticosteroids or long-acting beta-agonists was not.
Karyotyping of girls with short stature and high FSH levels would allow early diagnosis of Turner syndrome in a significant number of patients, especially where resources for chromosome study are limited.
Researchers examined the correlation between Cobb angle of kyphosis from lateral spine radiographs and pattern of self-reported menopausal hormone therapy use.
Variable improvements in menses, hormones, and metabolism were seen during 24 months of metformin use in 119 women with PCOS sub-grouped by baseline weight and androgen status.
Study evaluated the difference in the rate of ongoing pregnancy or live birth between frozen embryo transfer and fresh embryo transfer in women without polycystic ovary syndrome who were undergoing IVF.
The FDA has approved Zomacton, a somatropin injection, for the replacement of growth hormone in adults with GH deficiency.
Exposure to air pollution during high school is associated with a slightly higher likelihood of menstrual irregularity and longer time to regularity.
Medicaid policy encourages the use of long-acting reversible contraception, but state-level payment policies are inconsistent and often do not include critical aspects of care.
Researchers have found that lower alpha diversity is seen in women with polycystic ovary syndrome vs healthy women.
Women with migraine with aura are at an increased risk for stroke if they are taking high-dose estrogen-containing contraceptives.
The stair-step clomiphene protocol is associated with decreased time to ovulation for women with polycystic ovary syndrome.
A nonhormonal treatment option for the relief of symptoms associated with menopause is now available alongside other drug-free supplements.
The use of hormone therapy up to 5 years after onset of menopause is associated with a lower risk for ischemic and hemorrhagic stroke compared with late hormone therapy initiation or no hormone therapy use.
To update its 2012 recommendation, the US Preventive Services Task Force reviewed evidence on the benefits and harms of systemic hormone therapy for the prevention of chronic conditions in postmenopausal women.
Researchers found that 3061 postmenopausal women of 61,335 developed invasive breast cancer during a mean follow-up of 11.4 years. Women with weight loss (≥5%) had a significantly lower breast cancer risk than women with stable weight.
Products marketed as selective androgen receptor modulators and sold via the internet frequently contain unapproved drugs and substances, and the amount of active compound often does not match that listed on the label.
There may be other roles of estradiol therapy besides relief from menopause-related symptoms, including limiting effects of stress on working memory.
Guideline was developed under the direction of the Practice Committee of the American Society for Reproductive Medicine.
Underweight women have a significantly greater risk of experiencing early menopause compared with lean or overweight women.
Increased mortality risks were limited to the first post-HT year because increases in risks markedly decreased when the follow-up time was extended over more than 1 year.
Long-term exposure to progestin-only oral contraceptives or to a progestin intrauterine device is associated with a small beneficial effect on pelvic girdle pain.
No other randomized clinical trial of hormone therapy has been large enough to assess a potential modifying effect of age on all-cause mortality, and most previous trials of chronic disease outcomes have focused on older women.
Asthma may increase the likelihood of a woman needing fertility treatments prior to becoming pregnant.
Obese men have lower semen volume, number, concentration, and motility, as well as a higher prevalence of oligospermia and asthenospermia.
Predicted probability of conception was not significantly lower for women with low antimüllerian hormone vs those with normal hormone levels.
Researchers examined the efficacy of FlexibleMIB (ethinylestradiol/drospirenone) vs placebo as therapy for endometriosis-related pain.
While hirsutism may indicate metabolic abnormalities, acne and androgenic alopecia are associated with other clinical hyperandrogenism manifestations.
The newly released guidelines include updated language to reflect DSM-V changes, greater flexibility in treatment, and recommendations for CVD, bone health, and prostate cancer screening.
The Female Sexual Functioning Index was used to assess aspects of sexual function and experience in early postmenopausal women.
High costs associated with in vitro fertilization create barriers to fertility treatments that many cannot overcome.
Hyperandrogenic PCOS is associated with maternal pregnancy complications, including gestational diabetes.
Intrarosa, the first FDA approved local, non-estrogen product for treating dyspareunia, is now available.
Although the updated statement does not change the recommendations outlined in previous treatment guidelines, the authors have added 8 new recommendations based on evidence that has emerged in the interim.
Researchers examined menstrual patterns in 128 patients with either a sports-associated concussion or non-head injury.
A combination of early menstruation with more frequent periods may lower a woman's depression risk.
Patients attending VA clinics may experience variability in testosterone prescribing practices for hypogonadism.
Two studies examined the efficacy of acupuncture therapy for stress incontinence and PCOS, finding mixed results.
Data from a UK cohort were used to examine the relationship between maternal sugar intake levels and pediatric respiratory and atopic outcomes.
Acute decline in ovarian function may contribute to the autoimmunity associated with rheumatoid arthritis.
The North American Menopause Society released updated guidelines for hormone therapy use in women who are postmenopausal.
Gonadotropin-releasing hormone antagonist elagolix demonstrated clinical improvement for women with endometriosis-related pain.
Women with endometriosis who participated in the study expressed alternately being treated with ignorance and being ignored by their clinicians.
Research results indicate that more randomized clinical trials are needed to examine the relationship between hearing loss and oral hormone replacement therapy.
Testosterone has been identified as a "potent inhibitor" of lymphoid cells responsible for producing proteins that lead to lung inflammation.
Data from a systematic review and meta-analysis confirmed a higher risk of anxiety and depression in PCOS, but underlying factors are still unclear.
Serum samples, spirometry, and questionnaire data were collected from nearly 1500 women to determine if menopausal status affected lung function.
Incident falls were linked with total testosterone and bioavailable levels of testosterone after adjusting for age and prevalent falls.
Studies published in JAMA and JAMA Internal Medicine highlight the benefits and risks of treating men for low testosterone.
Severe anxiety was independently associated with poor quality of life in postmenopausal patients.
Data from the Nurses' Health Studies were analyzed to determine if there is a link between seropositive and seronegative rheumatoid arthritis and age of menopause onset.
Researchers have pinpointed harmonized references ranges for total testosterone levels in men.
For women with HIV, anti-Müllerian hormone is associated with age of menopause onset.
Outside of hormone therapy, endocrinologists reported having low confidence in their knowledge about caring for transgender patients.
Women in the menopausal transition and early postmenopause are at higher risk for depressive symptoms and negative mood than those in late postmenopause.
Menopausal status is associated with accelerated lung function decline.
Endocrinology Advisor Articles
- Diet Quality and Glycemic Control in Women With Gestational Diabetes
- Most Foods Containing Fructose Do Not Have Harmful Effect on Glycemic Control
- Effects of a Low-Carbohydrate Diet on Weight Loss Maintenance
- Sleep Quality in Women With Surgical vs Natural Menopause
- Unhealthy Lifestyle and Rotating Night Shifts Put Nurses at Higher Risk for T2D
- Hypothyroidism Treatment No Longer Available
- Obesity Subtype May Determine Outcomes After Bariatric Surgery
- Few Physicians Work in Practices That Use Telemedicine
- Skin Autofluorescence Predicts T2D, Heart Disease, Mortality
- ACC: Smoking Cessation Expert Decision Pathway Emphasizes Team-Based Support