Adrenal

Endocrine Society Updates Congenital Adrenal Hyperplasia Clinical Practice Guidelines

Endocrine Society Updates Congenital Adrenal Hyperplasia Clinical Practice Guidelines

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The guideline highlights shared decision making among patients, their families, and physicians for the management of congenital adrenal hyperplasia.

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.

Nonfunctioning Adrenal Incidentaloma Associated With Metabolic Syndrome

Nonfunctioning Adrenal Incidentaloma Associated With Metabolic Syndrome

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Investigators sought to determine the frequency of metabolic syndrome in patients with nonfunctioning adrenal incidentalomas.

Positive Results for Recorlev in Phase 3 Cushing Syndrome Trial

Positive Results for Recorlev in Phase 3 Cushing Syndrome Trial

Results from this single-arm, open-label study found that 30% of patients achieved normalization of mean urinary free cortisol (UFC) after 6 months of maintenance treatment with levoketoconazole, without a dose increase (P<.25).

Azedra Approved to Treat Rare Tumors of the Adrenal Gland

Azedra Approved to Treat Rare Tumors of the Adrenal Gland

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Azedra should be used by or under the control of physicians who are qualified by specific training and experience in the safe use and handling of radiopharmaceuticals.

Glucocorticoid Replacement Improves Circadian Rhythm in Adrenal Insufficiency

Glucocorticoid Replacement Improves Circadian Rhythm in Adrenal Insufficiency

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Administering glucocorticoid leads to entrainment of molecular clocks in human peripheral blood mononuclear cells by regulating BMAL-1 and PER2-3.

Age-Related Differences in Manifestation of Cushing Disease Identified

Age-Related Differences in Manifestation of Cushing Disease Identified

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Researchers assessed disease presentation and clinical outcomes in an older population of individuals with Cushing disease.

Case Shows Biotin Can Interfere With Multiple Endocrine Tests

Case Shows Biotin Can Interfere With Multiple Endocrine Tests

On laboratory tests, the authors identified an unusual endocrine hormonal profile, including pituitary hormones below reference intervals and gonadal and adrenal hormones above reference intervals.

Cardiovascular Function May Improve After Cure of Cushing Syndrome

Cardiovascular Function May Improve After Cure of Cushing Syndrome

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Study assessed cardiovascular function, quality of life, and mental/physical health in overt and cured Cushing syndrome.

Infants Hospitalized Most Often for Adrenal Insufficiency, Hypopituitarism

Infants Hospitalized Most Often for Adrenal Insufficiency, Hypopituitarism

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Rates of adrenal insufficiency and hypopituitarism were highest during infancy, particularly among females.

AAP Shares List of 5 Unnecessary Pediatric Tests and Procedures

AAP Shares List of 5 Unnecessary Pediatric Tests and Procedures

The American Academy of Pediatrics urges careful consideration between parents and clinicians prior to ordering these tests.

Pain Perception in Adrenal Insufficiency Not Affected by Hydrocortisone Dose

Pain Perception in Adrenal Insufficiency Not Affected by Hydrocortisone Dose

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Mechanical pain perception and somatosensory function in secondary adrenal insufficiency were examined.

Mild Cases of Cushing's Syndrome Present Diagnostic Challenges

Mild Cases of Cushing's Syndrome Present Diagnostic Challenges

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As a result of overlapping features with various other conditions, milder cases of Cushing's syndrome present diagnostic challenges and may require careful observation as well as biochemical and imaging tests.

Long-Term Testosterone Treatment Reduced HbA1c in Men With Hypogonadism and Type 2 Diabetes

Long-Term Testosterone Treatment Reduced HbA1c in Men With Hypogonadism and Type 2 Diabetes

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At 12 years of testosterone treatment, HbA1c decreased to 5.5±0.3%.

New Research Highlights Possible Genetic Cause of Cushing's Disease

New Research Highlights Possible Genetic Cause of Cushing's Disease

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The analysis led to the identification of 4 potentially pathogenic missense variants in CABLES1.

Severe Adrenal Deficiency With Topical Steroid Application for Psoriasis

Severe Adrenal Deficiency With Topical Steroid Application for Psoriasis

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The patient presented with symptoms consistent with adrenal deficiency following 18 years of topical steroid application.

Bone Mineral Density Changes Related to Adrenal Incidentalomas in Menopausal Women

Bone Mineral Density Changes Related to Adrenal Incidentalomas in Menopausal Women

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After 24 months, bone mineral density was statistically different from baseline.

Pediatric Endocrine Society Provides Guidance for Growth Hormone Use in Pediatric Patients

Pediatric Endocrine Society Provides Guidance for Growth Hormone Use in Pediatric Patients

The guidelines focused on idiopathic short stature, growth hormone deficiency, and primary IGF-I deficiency.

Growth Hormone Plus Aromatase Inhibitor in Congenital Adrenal Hyperplasia

Growth Hormone Plus Aromatase Inhibitor in Congenital Adrenal Hyperplasia

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A case report suggested that combination therapy with growth hormone and anastrozole may improve final height in congenital adrenal hyperplasia.

Study Identifies Major Risk Locus for Addison's Disease

Study Identifies Major Risk Locus for Addison's Disease

BACH2 is a major risk locus for Addison's disease, according to a study published in the Journal of Internal Medicine.

Higher Rate of Addison's Disease Seen in Patients Born in Winter Months

Higher Rate of Addison's Disease Seen in Patients Born in Winter Months

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In the United Kingdom, rates of the disease were highest for those born in December, while in Poland, rates were highest for those born in January.

Aldosterone Reduced With Losartan in Hypertension Without Obstructive Sleep Apnea

Aldosterone Reduced With Losartan in Hypertension Without Obstructive Sleep Apnea

For patients with hypertension and obstructive sleep apnea, treatment with losartan does not lead to significant reductions in aldosterone, but the treatment is tied to aldosterone reductions in patients with hypertension but without obstructive sleep apnea.

Diabetes Risk Higher With 'Nonfunctional' Adrenal Tumors

Diabetes Risk Higher With 'Nonfunctional' Adrenal Tumors

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Patients with nonfunctional adrenal tumors have a nearly 2-fold increased risk for diabetes.

Abnormal Adrenal Function May Affect Some Women With PCOS

Abnormal Adrenal Function May Affect Some Women With PCOS

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A portion of women with polycystic ovary syndrome may experience excess adrenal hormone production.

Left Adrenal Vein Aldosterone Ratio May Help Predict Right-Sided Unilateral Disease in Primary Aldosteronism

Left Adrenal Vein Aldosterone Ratio May Help Predict Right-Sided Unilateral Disease in Primary Aldosteronism

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A cutoff value less than 0.5 performed well for right-sided disease, but 5.5 cannot be used to reliably identify left-sided disease.

Mild Hypercortisolism Due to Adrenal Adenoma

Alice C. Levine, MD, discusses mild hypercortisolism due to adrenal incidentalomas.

Radiofrequency Ablation May Be Safe, Effective Treatment for Adrenal Neoplasms

Radiofrequency Ablation May Be Safe, Effective Treatment for Adrenal Neoplasms

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Researchers discuss a case in which a woman was successfully treated with radiofrequency ablation.

New Recommendations Intend to Increase Screening for Primary Aldosteronism

New Recommendations Intend to Increase Screening for Primary Aldosteronism

Updated recommendations from the Endocrine Society revise aldosteronism screening guidelines.

Hormone Insufficiencies May Be Prevalent After Blast Concussion in Veterans

Hormone Insufficiencies May Be Prevalent After Blast Concussion in Veterans

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Chronic hypopituitarism was noted in 44% of US veterans with mild traumatic brain injury.

Case Report Describes Cushing's Syndrome in Infant Treated With Ophthalmic Steroid

Case Report Describes Cushing's Syndrome in Infant Treated With Ophthalmic Steroid

Four-month-old developed iatrogenic Cushing's syndrome after 6 weeks of intranasal dexamethasone ophthalmic solution.

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