Adenosine Prefilled Syringes Rx

Indications for Adenosine Prefilled Syringes:

Paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome).

Adult:

Give peripherally by rapid bolus either directly into vein or through IV line (followed by saline flush) over 1–2 seconds. Initially 6mg; if no result within 1–2 mins, may give 12mg; may repeat a second 12mg dose if needed. Max 12mg/dose.

Children:

<50kg: Give centrally or peripherally by rapid IV bolus, followed by saline flush. Initially 0.05–0.1mg/kg; if no conversion of PSVT within 1–2 mins, may give incrementally higher doses, increasing the amount by 0.05–0.1mg/kg. Continue until sinus rhythm is established, or max single dose of 0.3mg/kg is used. ≥50kg: as adult.

Contraindications:

Sinus bradycardia. 2^nd- or 3^rd-degree AV block, sick sinus syndrome, unless paced.

Warnings/Precautions:

Attempt vagal maneuvers, when clinically advisable, before administration. Discontinue if high-level heart block occurs. Avoid in asthma. Obstructive lung disease (eg, emphysema, bronchitis). Discontinue if severe respiratory difficulties occur. Elderly. Pregnancy (Cat.C).

Pharmacological Class:

Nucleoside.

Interactions:

Concomitant digoxin +/– verapamil may cause ventricular fibrillation. Potentiated by dipyridamole. Antagonized by methylxanthines (eg, caffeine, theophylline). Carbamazepine may increase degree of heart block.

Adverse Reactions:

Facial flushing, dyspnea, chest pressure, nausea, headache, lightheadedness, numbness, arrhythmias at time of conversion; rare: ventricular fibrillation.

Note:

Formerly known under the brand name Adenocard.

How Supplied:

Contact supplier.