Generic Name and Formulations:
Zafirlukast 10mg, 20mg; tabs.
Indications for ACCOLATE:
Prophylaxis and chronic treatment of asthma.
Take 1hr before or 2hrs after meals. 20mg twice daily.
Take 1hr before or 2hrs after meals. <5yrs: not recommended. 5–11yrs: 10mg twice daily.
Not for primary treatment of acute attack. Discontinue if clinical symptoms of liver dysfunction occur; do not resume if confirmed by lab results. Caution when withdrawing from oral steroids. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Leukotriene receptor antagonist.
Potentiates warfarin (monitor PT and adjust warfarin dose). Caution with drugs metabolized by CYP2C9 (eg, tolbutamide, phenytoin, carbamazepine) or CYP3A4 (eg, dihydropyridine calcium channel blockers, cyclosporine, cisapride). Zafirlukast plasma levels reduced by erythromycin, theophylline. Zafirlukast plasma levels increased by aspirin. May increase theophylline levels.
Headache, infection, GI upset, pain, fever; neuropsychiatric events (eg, insomnia, depression); rarely, hepatic dysfunction (esp. in females), agranulocytosis.
Endocrinology Advisor Articles
- Cushing Syndrome Results in Poor Quality of Life Even After Remission
- DPP-4 Inhibitors and Incidence of Rheumatoid Arthritis in Type 2 Diabetes
- Cost-Benefit Analysis of Insulin Analogs in Type 2 Diabetes
- Nonfunctioning Adrenal Incidentaloma Associated With Metabolic Syndrome
- Low Predictive Power of Biomarkers for Estimated Glomerular Filtration Rate Decline
- Nutraceuticals May Benefit Patients Who Are Statin Intolerant
- Link Between Gestational Diabetes and Risk for CVD and Diabetes in Hispanic/Latina Population
- Clinical Characteristics Altering Risks and Benefits of Sulfonylureas and Thiazolidinedione Therapy in T2D
- 6 Factors Related to Inclusion in Health Care Workplace Identified
- Weight Gain After Quitting Smoking May Increase Risk for T2D