Is Normal Basal Bone Metabolism Vitamin D-Dependent in Postmenopausal Women With T2D?

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There was a correlation for changes in respiratory quotient with mean glycated hemoglobin levels.
There was a correlation for changes in respiratory quotient with mean glycated hemoglobin levels.

HealthDay News — For postmenopausal women with type 2 diabetes mellitus (T2DMPW), the correlation between bone metabolism and basal metabolism seems to be dependent on serum 25-hydroxyvitamin D (25[OH]D) levels, according to a study published online March 31 in the Journal of Diabetes Investigation.

Makiko Ogata, from the Tokyo Women's Medical University School of Medicine, and colleagues enrolled 44 T2DMPW in a prospective follow-up study performed with vitamin D supplementation. 

Twenty-three postmenopausal patients with low 25(OH)D levels were told to increase vitamin D levels by lifestyle change. Alfacalcidol was administered to 15 patients with osteoporosis.

The researchers found that serum 25(OH)D increased and decreased in 25 and 19 patients, respectively. A decrease in 25(OH)D was seen for patients who did not receive the study intervention at the start. 

There was a positive correlation between changes in resting energy expenditure and those of procollagen type 1 N-terminal propeptide (P1NP)/carboxy-terminal collagen crosslinks-1. 

There was a correlation for changes in respiratory quotient with mean glycated hemoglobin levels; after the intervention P1NP correlated positively with serum 25(OH)D. The correlations were prominent in those with increased 25(OH)D and alfacalcidol supplementation.

"Restoration of vitamin D level may be a prerequisite for a normal correlation between bone and basal metabolism in T2DMPW," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Reference

Ogata M, Iwasaki N, Ide R, et al. Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: a 6-month follow-up evaluation [published online March 31, 2017]. J Diabetes Investig. doi:10.1111/jdi.12666

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