Urine Metabolomic Profiling: 5-HT Metabolism Contributes to DM Pathogenesis

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Derangements in serotonin metabolism and mitochondrial dysfunction may be inhibiting insulin secretion.
Derangements in serotonin metabolism and mitochondrial dysfunction may be inhibiting insulin secretion.

Obese youth with type 2 diabetes have a distinct metabolomic profile, according to research presented at ENDO 2017: the 99th Annual Meeting & Expo, April 1-4, in Orlando, Florida.

Pinar Gumus Balikcioglu, MD, from the Duke University Medical Center in Durham, North Carolina., and colleagues recruited 33 obese African-American children ages 8 to 18 from pediatric obesity and diabetes clinics. 

Twenty-four hour urine samples were analyzed to identify key urinary metabolic signatures.

The researchers found that among 187 metabolites identified, three metabolites were significantly higher in obese youth with type 2 diabetes than in obese youth without diabetes. The 3 metabolites related to mitochondrial dysfunction and respiratory chain defects. 

Compared to those without diabetes, subjects with diabetes had a significantly lower level of one metabolite, 5-hydroxy-indoleacetic acid, the major metabolite of serotonin (P =.0007).

"Validation of our findings in larger clinical trials could provide a new noninvasive approach to identification of biomarkers for metabolic risk in both children and adults," Balikcioglu said in a statement. 

"More importantly, analysis of serotonin metabolism may provide new therapeutic targets for diabetes prevention and treatment."

Reference

Balikcioglu PG, Bain J, Muehlbauer M, O'Connell TL, Chalew SA, Freemark M. Pathogenesis of type 2 diabetes in obese adolescents: metabolites of serotonin and mitochondrial function in 24-hour urine samples. Abstract OR30-1. Presented at: ENDO 2017; April 1-4, 2017; Orlando, FL

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