Type 2 Diabetes
Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes.
A community health worker-led diabetes self-management education program is associated with sustained improvement in hemoglobin A1c.
To date, published experience with continuous subcutaneous insulin infusion use in the hospital is limited to just a few institutions, and primarily to those instances involving transitioning of the therapy from the outpatient to inpatient setting.
Patients initiating DPP-4 inhibitors as third-line therapy in type 2 diabetes appeared to have lower discontinuation rates and less hypoglycemia compared with patients starting NPH insulin.
Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.
Maintaining a basal insulin regimen over 12 or 24 months in a patient who has not yet reached the HbA1c <7% target provides little additional benefit toward reaching this goal.
Researchers found that the risk of developing type 2 diabetes was increased for lesbian and bisexual women vs heterosexual women.
Type 2 diabetes is independently associated with a greater risk of renal cell carcinoma in women, but not in men.
In European T2D cases, the researchers identified a novel signal near GABRR1, which was associated with microalbuminuria.
Markers of reproductive history, including age of menarche and parity, may be tied to future diabetes risk in women with a body mass index ≥25.
The paradoxical finding of accelerated wound healing and increase in HbA1c in participants with better baseline glycemic control requires confirmation in further studies.
Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.
Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.
Menstrual dysfunction is common in girls with recently diagnosed type 2 diabetes, and does not improve with 2years of anti-hyperglycemic treatment.
The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.
Study compared the real-world effectiveness of canagliflozin 300 mg vs dapagliflozin 10 mg on HbA1c reduction in patients with type 2 diabetes.
Researchers used multiparametric cardiovascular magnetic resonance imaging to examine the correlation between aortic stiffness and LV geometry in younger adults with type 2 diabetes.
Knowing that certain characteristics increase the risk for dermatology patients who may have metabolic syndrome will enable clinicians to identify patients who may have specific cardiovascular risks.
Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.
The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.
Results suggest that circadian preference and meal timing are novel and possibly modifiable risk factors for obesity in type 2 diabetes.
Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.
Further clinical trials are needed to explore the potential beneficial effect of vitamin D supplementation, via fortified foods and/or dietary supplements, on insulin resistance, and possibly on weight management.
Ethnicity,race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver.
HbA1c variability is a strong, independent predictor of all-cause mortality in patients with type 2 diabetes and appears to be more powerful than average HbA1c in predicting all-cause death.
Researchers examined the choroidal layer thickness in eyes of patients with diabetes to compare the findings based on medical history of systemic diabetes treatments and stage of diabetic retinopathy.
One-hour plasma glucose is a useful predictor of retinopathy risk, has a predictive value similar to that of 2-hour plasma glucose, and may be considered as an alternative glucose time point during an oral glucose tolerance test.
Family and friends' autonomy support may lead to better glycemic control by reducing distress among patients with diabetes.
SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for type 2 diabetesApril 20, 2018
SGLT-2 inhibitors or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment. Use of DPP-4 inhibitors was not associated with lower mortality than placebo or no treatment.
For overweight or obese adults with T2D, a long-term weight loss intervention is associated with a reduction in long-term disability.
Endocrinology Advisor Articles
- Use of In-Hospital Continuous Subcutaneous Insulin Infusion: A Consensus Statement
- Better Control With DPP-4 Inhibitors vs NPH Insulin in Type 2 Diabetes
- Achieving Glycemic Control in T2D After Basal Insulin Initiation
- Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up
- Effects of the Two Types of Anorexia Nervosa on Bone Metabolism
- Diabetes Treatments
- Incretins, Thiazolidinediones Associated With Better Glycemic Control in T2D
- No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers
- Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy
- Risk for Iodine Deficiency and Hypothyroidism High in Children on Parenteral Nutrition
- Inverse Association Between Serum 25(OH)D Levels and Risk for Diabetes
- Glycemic Control Variations for Children, Adolescents With T1D in High-Income Countries
- Late-Life Mobility Limitations Linked to Obesity After Arthroplasty for OA in Women
- Fracture Risk Should Be Monitored in Bisphosphonate Drug Holiday
- Provider Counseling for Weight Loss Up for Arthritis, Overweight