Type 2 Diabetes

Inverse Association Between Serum 25(OH)D Levels and Risk for Diabetes

Inverse Association Between Serum 25(OH)D Levels and Risk for Diabetes

By

Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes.

Community Health Worker-Led Intervention Beneficial in T2D

Community Health Worker-Led Intervention Beneficial in T2D

A community health worker-led diabetes self-management education program is associated with sustained improvement in hemoglobin A1c.

Use of In-Hospital Continuous Subcutaneous Insulin Infusion: A Consensus Statement

Use of In-Hospital Continuous Subcutaneous Insulin Infusion: A Consensus Statement

By

To date, published experience with continuous subcutaneous insulin infusion use in the hospital is limited to just a few institutions, and primarily to those instances involving transitioning of the therapy from the outpatient to inpatient setting.

Better Control With DPP-4 Inhibitors vs NPH Insulin in Type 2 Diabetes

Better Control With DPP-4 Inhibitors vs NPH Insulin in Type 2 Diabetes

By

Patients initiating DPP-4 inhibitors as third-line therapy in type 2 diabetes appeared to have lower discontinuation rates and less hypoglycemia compared with patients starting NPH insulin.

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

Type 2 Diabetes Linked With Higher Risk for Hip Fractures

By

Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.

Achieving Glycemic Control in T2D After Basal Insulin Initiation

Achieving Glycemic Control in T2D After Basal Insulin Initiation

By

Maintaining a basal insulin regimen over 12 or 24 months in a patient who has not yet reached the HbA1c <7% target provides little additional benefit toward reaching this goal.

Lesbian, Bisexual Women More Likely to Develop T2D at Younger Age

Lesbian, Bisexual Women More Likely to Develop T2D at Younger Age

Researchers found that the risk of developing type 2 diabetes was increased for lesbian and bisexual women vs heterosexual women.

Type 2 Diabetes Increases Risk for Renal Cancer in Women, but Not Men

Type 2 Diabetes Increases Risk for Renal Cancer in Women, but Not Men

Type 2 diabetes is independently associated with a greater risk of renal cell carcinoma in women, but not in men.

Novel Signal Identified for Microalbuminuria in Europeans With T2D

Novel Signal Identified for Microalbuminuria in Europeans With T2D

In European T2D cases, the researchers identified a novel signal near GABRR1, which was associated with microalbuminuria.

Reproductive Markers Associated With Risk of Diabetes

Reproductive Markers Associated With Risk of Diabetes

Markers of reproductive history, including age of menarche and parity, may be tied to future diabetes risk in women with a body mass index ≥25.

No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

By

The paradoxical finding of accelerated wound healing and increase in HbA1c in participants with better baseline glycemic control requires confirmation in further studies.

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza

By

Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

By

Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.

Irregular Menstruation Common in Girls With Type 2 Diabetes

Irregular Menstruation Common in Girls With Type 2 Diabetes

Menstrual dysfunction is common in girls with recently diagnosed type 2 diabetes, and does not improve with 2years of anti-hyperglycemic treatment.

Childhood Insulin Resistance Associated With Later Psychosis

Childhood Insulin Resistance Associated With Later Psychosis

By

The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.

SGLT2 Inhibitors Canagliflozin, Dapagliflozin Compared in Real-World Study

SGLT2 Inhibitors Canagliflozin, Dapagliflozin Compared in Real-World Study

By

Study compared the real-world effectiveness of canagliflozin 300 mg vs dapagliflozin 10 mg on HbA1c reduction in patients with type 2 diabetes.

Aortic Stiffness, Concentric LV Remodeling Linked in Type 2 Diabetes

Aortic Stiffness, Concentric LV Remodeling Linked in Type 2 Diabetes

Researchers used multiparametric cardiovascular magnetic resonance imaging to examine the correlation between aortic stiffness and LV geometry in younger adults with type 2 diabetes.

Metabolic Syndrome and Skin Disorders: Association Is More Than Skin Deep

Metabolic Syndrome and Skin Disorders: Association Is More Than Skin Deep

By

Knowing that certain characteristics increase the risk for dermatology patients who may have metabolic syndrome will enable clinicians to identify patients who may have specific cardiovascular risks.

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

Hip Fracture Risk May Be Overestimated in Type 2 Diabetes

By

Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.

CDC Reports on Diabetes Prevalence by Type in the United States

CDC Reports on Diabetes Prevalence by Type in the United States

By

The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.

Evening Preference Linked to Higher BMI in Type 2 Diabetes

Evening Preference Linked to Higher BMI in Type 2 Diabetes

Results suggest that circadian preference and meal timing are novel and possibly modifiable risk factors for obesity in type 2 diabetes.

Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy

Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy

By

Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.

Vitamin D Insufficiency Associated With Insulin Resistance Independent of Obesity in Children

Vitamin D Insufficiency Associated With Insulin Resistance Independent of Obesity in Children

By

Further clinical trials are needed to explore the potential beneficial effect of vitamin D supplementation, via fortified foods and/or dietary supplements, on insulin resistance, and possibly on weight management.

Factors Identified to Predict Fatty Liver in Obese Teens

Factors Identified to Predict Fatty Liver in Obese Teens

Ethnicity,race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver.

HbA1c Variability Predicts All-Cause Mortality in Type 2 Diabetes

HbA1c Variability Predicts All-Cause Mortality in Type 2 Diabetes

By

HbA1c variability is a strong, independent predictor of all-cause mortality in patients with type 2 diabetes and appears to be more powerful than average HbA1c in predicting all-cause death.

Choroidal Thickness Changes in Patients With Untreated Diabetes

Choroidal Thickness Changes in Patients With Untreated Diabetes

Researchers examined the choroidal layer thickness in eyes of patients with diabetes to compare the findings based on medical history of systemic diabetes treatments and stage of diabetic retinopathy.

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

One-hour plasma glucose is a useful predictor of retinopathy risk, has a predictive value similar to that of 2-hour plasma glucose, and may be considered as an alternative glucose time point during an oral glucose tolerance test.

Social Support of Autonomy Tied to Better Glycemic Control in Diabetes

Social Support of Autonomy Tied to Better Glycemic Control in Diabetes

Family and friends' autonomy support may lead to better glycemic control by reducing distress among patients with diabetes.

SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for type 2 diabetes

SGLT-2 inhibitors or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment. Use of DPP-4 inhibitors was not associated with lower mortality than placebo or no treatment.

Intensive Lifestyle Interventions Cut Long-Term Disability in Type 2 Diabetes

Intensive Lifestyle Interventions Cut Long-Term Disability in Type 2 Diabetes

For overweight or obese adults with T2D, a long-term weight loss intervention is associated with a reduction in long-term disability.

Sign Up for Free e-Newsletters

CME Focus