Positive Outcomes in Oral Glucose Challenge With Resistance Training in T2D
Seventeen sedentary patients underwent 6 weeks of whole-body resistance training.
HealthDay News — Resistance training is associated with improvement in oral glucose challenge (OGC)-stimulated muscle microvascular blood flow (MBF) and glycemic control, according to a study published online in Diabetes Care.
Ryan D. Russell, PhD, from the University of Tasmania in Hobart, Australia, and colleagues assessed 17 sedentary patients with type 2 diabetes who underwent 6 weeks of whole-body resistance training. Before and after resistance training, clinical chemistries were measured in participants who fasted overnight, and then they underwent an OGC.
The researchers found that muscle MBF response to the OGC increased after resistance training, while there was no change in skin microvascular responses. Improved glycemic control accompanied these microvascular adaptations, as did increased lean body mass and reductions in fasting plasma triglyceride, total cholesterol, advanced glycation end products, and total body fat. There was a significant correlation for changes in muscle MBF response after resistance training with reductions in fasting blood glucose, HbA1c, and OGC area under the curve with adjustment for age, sex, percent body fat, and percent lean mass.
"Resistance training improves OGC-stimulated muscle MBF and glycemic control concomitantly, suggesting that MBF plays a role in improved glycemic control from resistance training," the authors write.
Russell RD, Hu D, Greenaway T, et al. Skeletal muscle microvascular-linked improvements in glycemic control from resistance training in individuals with type 2 diabetes [published online July 2017]. Diabetes Care. doi:10.2337/dc16-2750