SGLT2 Inhibitor Effective With Low-Carb, High-Carb Diet in Type 2 Diabetes

Efficacy of luseogliflozin was similar with both a lo
Efficacy of luseogliflozin was similar with both a lo

HealthDay News -- For patients with type 2 diabetes, the SGLT2 inhibitor luseogliflozin has similar efficacy when meals contain 40% to 55% total energy from carbohydrate (TEC), according to a study published in Diabetes, Obesity and Metabolism.

Daisuke Yabe, MD, PhD, from the Kansai Electric Power Research Institute in Kobe, Japan, and colleagues examined the safety and efficacy of luseogliflozin under differing carbohydrate intake in Japanese individuals with type 2 diabetes. Participants were randomly assigned to carbohydrate-adjusted meals for 14 days: high carbohydrate (HC; 55% TEC)-high glycemic index (HGI), HC-low glycemic index (LGI), and low carbohydrate (LC; 40% TEC)-HGI. Participants had received luseogliflozin for the past 7 days and underwent continuous glucose monitoring (CGM) before and after luseogliflozin treatment.

The researchers found that in all 3 groups, luseogliflozin significantly decreased the area under the curve and mean CGM values to a similar extent. At all time points, fasting plasma glucose, insulin, and glucagon were similar. On day 15, ketone bodies were significantly increased in LC-HGI vs HC-HGI and HC-LGI.

"In conclusion, luseogliflozin has similar efficacy and safety in Japanese type 2 didabetes individuals when meals contain 40% to 55% TEC, but a strict low-carbohydrate diet on this class of drug should be avoided to prevent SGLT2 inhibitor-associated diabetic ketoacidosis," the researchers wrote.

Disclosures: Several authors disclosed financial ties to pharmaceutical companies, including Taisho Toyama, which manufactures luseogliflozin and funded the trial.

Reference

  1. Yabe D, Iwasaki M, Kuwata H, et al. SGLT2 inhibitor use and dietary carbohydrate intake in Japanese individuals with type 2 diabetes: a randomized, open-label, 3-arm parallel comparative exploratory study [published online December 19, 2016]. Diabetes Obes Metab. doi:10.1111/dom.12848.
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