Insulin Resistance Impacted by Circulating Extracellular RNAs
Eighteen extracellular RNAs were linked to insulin resistance across age-, sex-, and BMI-adjusted models.
HealthDay News — Circulating extracellular RNAs (ex-RNAs) are associated with insulin resistance, according to a study published online in Diabetes Care.
Ravi Shah, MD, from Massachusetts General Hospital in Boston, and colleagues examined the correlation between ex-RNAs and metabolic phenotypes in 2317 participants without diabetes in the Framingham Heart Study (FHS) Offspring Cohort. The correlation between candidate ex-RNAs and markers of adiposity was measured. Individuals with diabetes were included in sensitivity analyses. Selected ex-RNAs and metabolites were measured in a separate cohort of 90 overweight/obese youth.
The researchers found that across 391 ex-RNAs in FHS, 18 were associated with insulin resistance in age-, sex, and body mass index-adjusted models. Independent of metabolites, miR-122 correlated with insulin resistance and regional adiposity in adults and insulin resistance in children. Metabolic regulatory roles for miR-122, including regulation of insulin resistance pathways, was observed on pathway analysis.
"These results provide translational evidence in support of an important role of ex-RNAs as novel circulating factors implicated in insulin resistance," the authors write.
Shah R, Murthy V, Pacold M, et al. Extracellular RNAs are associated with insulin resistance in metabolic phenotypes [published online February 9, 2017]. Diabetes Care. doi: 10.2337/dc16-1354