Incident Diabetes May Explain Association Between Sleep Duration and CHD
Associations between sleep duration and incident CHD directly reflected the associations between sleep duration and incident diabetes.
The association between sleep duration and incident diabetes may be similar to the association between sleep duration and incident coronary heart disease (CHD), according to a study published in Diabetologia.
Researchers identified men (n=6966) and women (n=9378) from the Malmo Diet Cancer prospective study in Malmo, Sweden, who did not have a history of diabetes or CHD.
Habitual sleep duration was assessed in participants by means of open-ended questions, with a mean follow up in men of 14.2 to 15.2 years, and 15.8 to 16.5 years in women. The primary end point of the study was to investigate the possible association between short/long sleep duration and incident CHD.
Study results found an association between short sleep duration and the development of incident diabetes (non-diabetes CHD), CHD, and diabetes-CHD (CHD following incident diabetes) (hazard ratio [HR] 1.35, 95% CI 1.01-1.80; HR 1.41, 95% CI 1.06-1.89; HR 2.34, 95% CI 1.20-4.5, respectively).
Interestingly, long sleep duration in men was also found to be associated with incident diabetes, CHD, and diabetes-CHD (HR 1.37, 95% CI 1.03-1.83; HR 1.33, 95% CI 1.01-1.75; HR 2.10, 95% CI 1.11-4.00, respectively). In women, only short sleep duration was found to be associated with incident diabetes, CHD, and diabetes-CHD (HR 1.53, 95% CI 1.16-2.01; HR 1.46, 95% CI 1.03-2.07; HR 2.88, 95% CI 1.37-6.08, respectively). No association was found between short or long sleep duration and incident non-diabetes CHD (CHD before incident diabetes) in either men or women.
Researchers concluded that there is a strong association between sleep duration and incident CHD, with incident diabetes being explained as the biologic mechanism for CHD developing.
Therefore, clinicians should implement interventions focused on an individual's sleep duration, which could ultimately have an impact on the development of diabetes and the related illnesses that occur as a result of diabetes.
Svensson AK, Svensson T, Kitlinski M, et al. Incident diabetes mellitus may explain the association between sleep duration and incident coronary heart disease [published online on November 4, 2017]. Diabetologia. doi: 10.1007/s00125-017-4464-3