Twice-Daily Exenatide Effective Across BMI Ranges in Type 2 Diabetes

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Adding exenatide to insulin glargine appears to be effective across BMI ranges.
Adding exenatide to insulin glargine appears to be effective across BMI ranges.

(HealthDay News) — For patients with type 2 diabetes, exenatide twice daily added to insulin glargine is efficacious across BMI ranges, according to a study published in Diabetes, Obesity and Metabolism.

Bruce H.R. Wolffenbuttel, MD, PhD, from the University of Groningen in the Netherlands, and colleagues examined the correlation between BMI ranges and treatment effects of exenatide twice daily among patients with type 2 diabetes. In 2 30-week studies, patients received exenatide in addition to insulin glargine (exenatide vs insulin lispro: 627 patients; and exenatide vs placebo: 259 patients).

The researchers observed no correlation for baseline BMI with changes in efficacy parameters. Significant and similar reductions were seen in HbA1c (P<.0001) across BMI range groups in the lispro-comparator study; in the placebo-controlled study, HbA1c reductions were greater for exenatide vs placebo. 

Across BMI groups, significant weight loss occurred with exenatide (P<.0001); weight increased with both comparators. Exenatide correlated with greater achievement of HbA1c less than 7.0% without weight gain relative to comparators. 

Across BMI range groups, systolic blood pressure changes decreased with exenatide in the lispro-comparator study (P<.0001); there were no clinically meaningful changes in lipids.

"These findings suggest that BMI alone should not limit clinical decision-making or patient access to medication," the researchers wrote.

Several authors disclosed financial ties to pharmaceutical companies, including some that supported the studies in this analysis and AstraZeneca, which manufactures exenatide and supported manuscript development and medical writing.

Reference

  1. Wolffenbuttel BHR, Gaal LV, Garcia SD, Han J. Relationship of body mass index with efficacy of exenatide twice daily added to insulin glargine in patients with type 2 diabetes. Diabetes Obes Metab. 2016. doi:10.1111/dom.12669.
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